[Whole body irradiation before bone marrow transplantation in malignant systemic diseases].
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Acute Disease↗
Biomedical subjects
D Hornung
Publications and source records attributed to D Hornung.
[Arthrograph and operative findings (author's transl)].
Arthrograph and operative findings were compared retrospectively in 57 patients (53 examinations of the knee-,3 of the shoulder-, and 1 of the hip-joint). In medial disk lesions there were differences between arthrograph and operation in 19% (13,5 false positive and 5,5% false negative). In lateral disk lesions there were differences in 13% (5,5% false positive und 7,5% false negative). In a prospective series the results were far better. There were no differences for the shoulder and the hip-joint.
Adult↗
[Biological and radioimmunological studies on human prolactin, human growth hormone, and human placental lactogen].
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Animals↗
Hormonal changes in urine and plasma in patients with various testicular tumours before and after treatment. I. Seminoma.
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Adult↗
Hormonal changes in urine and plasma in patients with various testicular tumours before and after treatment. II. Malignant teratoma of intermediate type B and malignant trophoblastic teratoma.
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Adult↗
Expression of monocyte chemotactic protein-1 in human endometrial cancer cells and the effect of treatment with tamoxifen or buserelin.
Monocyte chemotactic protein-1 (MCP-1) is an important determinant of macrophage infiltration in tumours. This study investigated the effect of tamoxifen and the gonadotrophin-releasing hormone agonist buserelin on MCP-1 in the human endometrial cancer cell line EFE-184. Reverse transcription polymerase chain reaction and Western blot analysis were used to determine MCP-1 mRNA and protein expression, respectively. Immunoreactive MCP-1 in the cell culture media was quantified by enzyme-linked immunosorbent assay. Tamoxifen inhibited MCP-1 mRNA and protein expression in endometrial cancer cells and inhibited MCP-1 secretion in a time- and dose-dependent manner at concentrations of 10(-7) to 10(-5) M. Buserelin had no significant effect on MCP-1 mRNA and protein expression. These results suggest that tamoxifen directly inhibits the expression of MCP-1 in this cell line by blocking the MCP-1 signalling pathways. These findings may contribute to the understanding of the mechanisms underlying the different effects of tamoxifen and gonadotrophin-releasing hormone agonists in the treatment of endometrial cancer.
Antineoplastic Agents, Hormonal↗