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Biomedical subjects

D Hillman

Publications and source records attributed to D Hillman.

59 records · Page 4Linked to original sources
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The blood pressure and heart rate chronome of centenarians.

Rhythm characteristics of blood pressure (BP) and heart rate (Hr) of 11 healthy centenarians and 66 medical students are described. Each subject ambulatorily monitored measured BP and HR around the clock at 15-min intervals for 48 hours. Least-squares spectra were obtained by the fit of cosine curves (cosinor) and compared between the two populations. Confounding by geographic differences seems to be ruled out by comparisons with results from international data bases. A shift in prominence from the circadian domain to higher frequency harmonics was found for the BP but not for the HR of centenarians. In clinically mostly healthy centenarians, markers of primary aging may consist of a relatively low circadian BP and HR amplitude and a tendency toward internal and external desynchronization. Whether these chronobiologic changes with age are desirable, indifferent or undesirable can now be elucidated by outcome studies, in the light of the reference standards provided herein.

Activity Cycles↗
PubMedDate not supplied

Ambulatory blood pressure monitor and 'analyzer'.

Earlier, we described the format provided by an ambulatory blood pressure monitor, the ABPM-630 with a data handler (AA-200), manufactured by Colin Medical Instruments. A detailed procedure for data transfer from the memory cassette into the analyzer and into an IBM PC in a format compatible with programs in the Chronobiology Laboratories is provided with a brief description of the hardware used. Among several instruments available for ambulatory blood pressure and heart rate monitoring, the ABPM-630 has several advantages: it does not require electrodes (a merit it shares with other instruments); it is portable, even if there are smaller ones; it functions silently, being activated by a CO2 cartridge; and it provides data obtained by two methods, by auscultation and by oscillometry, in part as a backup for one another, depending on whether auditory or movement noise are within limits acceptable to the instrumentation. This feature renders it more likely that some record will be obtained. In our earlier publication, we had referred to and then briefly described a special program which converts the format of the data handler into a format acceptable for analyses with programs from the University of Minnesota Chronobiology Laboratories. Herein, the operation of transferring data from the ABPM-630 memory cassette to an IBM-compatible personal computer (PC) is described, with an indication further of the programs used in the Chronobiology Laboratories.

Ambulatory Care↗
PubMedDate not supplied

Chronobiology: a frontier in biology and medicine.

On the occasion of Franz Halberg's 70th birthday, some of his many achievements are reviewed. We provide a historical background to the development of chronobiology; offer insight into the current state of this new science; and sketch the promise of this discipline for health care and cure. As a tribute to Franz Halberg, in an era of fast-growing technology, an attempt is made to describe his perspective of tomorrow's medicine and biology. The many students he trained throughout his productive career face the challenge of deserving the trust he placed in them and of further implementing his vision. A leader in social pediatrics put it aptly: it will take several generations of researchers to study and master his life's work.

Animals↗