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Biomedical subjects

D Herbert

Publications and source records attributed to D Herbert.

At least 55 records · Page 3Linked to original sources
PubMed1982

Growth hormone, prolactin and FSH release by the tachykinin dodecapeptide kassinin in the rat.

The effect of equimolar doses of kassinin, a newly discovered tachykinin dodecapeptide, and substance P on serum growth hormone, prolactin and FSH was examined in adult male Fischer 344 rats. The two peptides were injected intravenously 10 or 30 min prior to blood collection by decapitation. Kassinin in concentrations of 0.3 and 3.0 micrograms/100 g B.W., potently stimulated release of growth hormone. Both kassinin and substance P decreased prolactin at the lowest dose. An increase of serum prolactin above control values by both peptides was observed at the highest dose administered. However, this increase with the highest dose depended on the time of blood collection. Serum FSH was increased only by injection of the highest dose of kassinin or substance P. These results demonstrate that kassinin and substance P have similar effects on the secretion of these hormones. The findings provide further evidence for an involvement of peptidergic neurons in the regulation of pituitary function. Kassinin, if present in central and peripheral neurons of the mammalian central and autonomic nervous system and in the cells of the diffuse neuroendocrine system, could function as a neuropeptide.

Animals↗
PubMed1981

Xenon enhanced dynamic computed tomography: multilevel cerebral blood flow studies.

Xenon enhanced computed tomography with a fast scanning mode and interscan table incrementation was used to derive local cerebral blood flow in a nonhuman primate 19 days following infarction. The in vivo autoradiographic methodology was used to derive blood flow in normal and diseased tissue at four different brain levels (slices) during a single inhalation study.

Animals↗
PubMed1980

Significance of Aspergillus species isolated from respiratory secretions in the diagnosis of invasive pulmonary aspergillosis.

To determine the significance of Aspergillus species isolated from sputum or other respiratory secretions with respect to the diagnosis of invasive pulmonary aspergillosis, the clinical records and radiographs of all patients whose respiratory secretion cultures yielded an Aspergillus species between 1972 and 1978 were reviewed. All known predispositions to invasive aspergillosis, e.g., presence of cancer or granulocytopenia, and therapy with corticosteroids, antibiotics, and cytotoxic drugs, were significantly associated with proven or probable invasive pulmonary aspergillosis. Most notable were patients with acute leukemia and granulocytopenia. Prolonged duration of hospitalization between initial isolation (greater than 2 weeks) and multiple isolates (greater than three isolates) were also significantly associated with a high frequency of proven or probable disease. Isolation of A. niger was only rarely associated with proven or probable disease (one of eight patients). The isolation of A. fumigatus and A. flavus from respiratory secretions does not usually represent laboratory contamination and must be interpreted in the light of known predispositions to aspergillosis. In some situations, e.g., granulocytopenic patients with acute leukemia, even a single isolation carries a high likelihood of invasive aspergillosis.

Adrenal Cortex Hormones↗
PubMed1979

Costs in a clinical pharmacological laboratory.

As a measure of the efficiency of service provided to the Groote Schuur group of hospitals by the Department of Clinical Pharmacology, certain costs were analaysed. The approximate annual cost of routine analytical work was R40 000 $45 000 or 22 000 pounds). The average cost per assy was R9,50 ($11,30 or 5,50 pounds). Closer examination of data showed that the cheapest assays are those done in large batches using an off-line analytical technique such as thin-layer chromatographic densitometry.

Chemistry, Clinical↗