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Biomedical subjects

D Henson

Publications and source records attributed to D Henson.

At least 37 records · Page 2Linked to original sources
PubMed1986

Importance of visual field score and asymmetry in the detection of glaucoma.

The visual fields and intraocular pressures (IOP's) of 115 normal volunteers and 107 suspect/diagnosed early glaucoma subjects were recorded by Friedmann static perimetry and noncontact tonometry or applanation tonometry. The visual field data were analyzed statistically and quantified numerically by a microcomputer. The readings obtained from the suspect/diagnosed early glaucoma subjects were compared to those from an age-matched control group according to four criteria: highest field score; field score asymmetry; highest IOP; and IOP asymmetry. A combined field score and asymmetry analysis was found to be more sensitive, 86%, than a combined IOP and IOP asymmetry analysis, 56%. The combined field score and field score asymmetry analysis also gave a clear bimodal separation of subjects with early visual field defects from those with normal visual function.

Adult↗
PubMed1980

Micropachometry: a technique for measuring the thickness of the corneal epithelium.

A micropachometer was developed for the measurement of epithelial thickness in the living human cornea. The technique requires no contact with the eye and will be of value in studies of the anterior cornea and the physiological effects of contact lenses. The design is described, and results are presented from measurements of epithelial thickness.

Biometry↗
PubMed1979

A study of lobular carcinoma of the breast based on the Third National Cancer Survey in The United States of America.

Cases in in situ and infiltrating lobular carcinoma of the breast reported in the Third National Cancer Survey were reviewed according to age, sex, race, and geographic distribution. The age-specific incidence rates indicate that there are two peak age periods of risk for invasive lobular carcinoma, the first occurring in ages 40-50 years and the second after age 65. The incidence rates for lobular carcinoma were compared to the incidence rates for intraductal and infiltrating ductal carcinoma reported from the Third National Cancer Survey and for total breast cancer from the Miyagi prefecture in Japan. These comparisons indicate that factors which influence the geographic variation in breast cancer play important roles in the etiology of infiltrating ductal carcinoma, but may have little effect upon the incidence of lobular carcinoma and intraductal carcinoma. The limitations of large histological epidemiological surveys are discussed.

Adult↗
PubMed1979

Color as a variable in making an erotic film more arousing.

Eight adult male subjects participated in a counterbalanced, repeated-measures design to determine the relative efficacy of color and black-and-white visual sexual stimuli in eliciting sexual arousing, as objectively measured by a mercury-in-rubber strain gauge transducer. There were no consistent or significant differences in either the intensity of the pattern of penile responding during color and black-and-white presentations of the same film.

Adult↗
PubMed1977

An epidemiologic study of cancer of the cervix, vagina, and vulva based on the Third National Cancer Survey in the United States.

Cases of invasive and in situ carcinoma of the lower female genital tract as reported in the Third National Cancer Survey in the United States were analyzed according to age, race, and geographic distribution. Results indicate that the incidence rates of in situ and invasive carcinoma of the cervix were greater in black than in white women, with a relative risk rate for black women of approximately two for both types of cervical carcinoma. For white women, the age-specific rates for invasive carcinoma of the cervix remained relatively constant after age 45, while for black women the age-specific rates for invasive carcinoma continued to increase after age 45. For both races, the patterns of age-specific incidence rates for in situ and invasive carcinoma of the cervix were not similar to those for carcinoma of the vagina or vulva. The pattern of age-specific incidence rates of adenocarcinoma of the cervix did not resemble those for in situ or invasive squamous cell carcinoma of the cervix. The rates for adenocarcinoma of the cervix demonstrated patterns similar to those for intraductal carcinoma of the breast. Results of the study are discussed in relationship to the field theory of carcinogenesis as developed for the lower female genital tract.

Adenocarcinoma↗
PubMed1972

Chronic infection of the rabbit central nervous system by a slowly growing equine herpesvirus.

The spinal cords of rabbits were chronically infected by a slowly growing horse herpesvirus (a "cytomegalovirus") inoculated directly therein. Virus was recovered from the central nervous systems of some of such animals after more than 1 year. The virus could be reisolated from all the animals killed during the first few weeks after its injection; acute focal meningomyelitis was present with involvement of gray and white matter of the cervical, thoracic, and lumbar levels of the spinal cords of these rabbits, though the nerve cells themselves remained undamaged. Thereafter, reisolation of the virus became sporadic, and no damage to the spinal cord could be histologically discerned even in animals from which the virus was recovered. No paralytic or other clinical effects could be attributed to the infection.

Animals↗
PubMed1972

Mouse cytomegalovirus. Necrosis of infected and morphologically normal submaxillary gland acinar cells during termination of chronic infection.

The ultrastructural lesions in the submaxillary glands of C(3)H mice chronically infected with the murine cytomegalovirus are reported. Virus was synthesized in the nucleus of acinar glandular cells. After passage into the cytoplasm, virus was located in large vesicles which were derived from the Golgi apparatus. These vesicles, which were periodic acid-Schiff positive, migrated to the apex of the cell and released virus into the acinar lumen or canaliculi. Eventually, lymphocytes infiltrated the interstitium and surrounded the basal lamina of acini which contained infected cells. In acini encompassed by lymphocytes, both infected cells and morphologically normal acinar cells simultaneously degenerated, producing a small focus of necrosis. Physical contact between lymphocytes and necrotic cells did not occur for an intact basal lamina was always found interposed between them. Degeneration of infected cells coincided with a decrease in virus titer in the salivary glands. Degeneration of infected and normal acinar cells also occurred in DBA 2 mice which lack the fifth component of complement. In mice conditioned with cortisone to suppress inflammation, neither infected nor normal acinar cells degenerated. We concluded from the electron microscope observations that lymphocytes terminate chronic MCMV infection, that MCMV infection of acinar epithelium is not cytolytic and that normal cells also undergo necrosis during termination of chronic MCMV infection. It is postulated that lymphocytes in responding to infection release a cytotoxic substance which diffuses into the acini and causes indiscriminate necrosis of acinar cells.

Animals↗