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Biomedical subjects

D Henin

Publications and source records attributed to D Henin.

At least 73 records · Page 4Linked to original sources
PubMed1988

[Anoxic encephalopathy after cardiocirculatory insufficiency. Neuropathological study apropos of 16 cases].

Sixteen cases of anoxic encephalopathy in adult patients admitted to the intensive Care Department of Raymond Poincaré Hospital (Garches) have been selected on the following criteria: resuscitation by external cardiac massage for cardio-respiratory failure, without any previous history of anoxia and with detailed data on the subsequent evolution of neurological signs and symptoms. Main clinical features were compared to the results of the neuropathological examination. The pattern and the distribution of changes are detailed. The cerebral cortex was always involved by diffuse ischemic cell changes or by laminar necrosis. The Sommer's sector of Ammon's horn was affected in 15 cases, the basal ganglia in 14, the cerebellum in 11, the brain stem in 6. The very rarely mentionned necrotic brain stem changes, which involved inferior colliculi, periaqueductal gray matter and substantia nigra were sometimes associated with lesions of the floor of the IVth Ventricle and of the mamillary bodies. They were different from Wernicke's encephalopathy with could be dismissed on clinical and pathological grounds. No clinical signs or symptoms specific for this distribution of changes could be found by the retrospective study of the clinical files.

Adolescent↗
PubMed1987

[Amnesia and stiff-man syndrome. Manifestations disclosing paraneoplastic encephalomyelitis].

The authors report a case of hypertonia, the clinical and electrophysiological features of which were identical to those of the Stiff-man syndrome first described by Moersch and Woltman in 1956. This and the five other previously reported cases can be attributed to encephalomyelitis of the anterior horns of the spinal cord. All of these cases had severe but partial involvement of the anterior horns and the probable physiopathological mechanism of the resulting contractures was elective destruction of the small inhibitory neurones. In the present case, the association of a limbic encephalitis and secondary exteriorization of a carcinoma of the pharynx, strongly suggested a paraneoplasic encephalomyelitis. This is the first report indicating an association between the Stiff man syndrome and a paraneoplastic syndrome. Another point of interest was the spectacular response of the hypertonia to steroid therapy suggesting a central neuropharmacological effect quite apart from the non specific anti-inflammatory action on the encephalomyelitis.

Amnesia↗
PubMed1987

AIDS subacute encephalitis. Identification of HIV-infected cells.

Human immunodeficiency virus (HIV) RNA and proteins were detected in the brains of several AIDS patients with subacute encephalitis, by in situ hybridization and immunohistology. The majority of infected cells were mononucleated and bore processes. Using single and double immunohistologic procedures, the authors identified these cells as macrophages. The majority of them had the phenotype of microglial cells (Leu-M3-, CD4-), others were labeled with markers of circulating macrophages (Leu-M3+, CD4+/-). The presence of HIV RNA and proteins in CD4- cells could be explained by depressed CD4 antigen expression, as a result of infection or macrophage tissue differentiation.

Acquired Immunodeficiency Syndrome↗
PubMed1985

[Reflections on surgery of high lesions of the internal carotid. Experimental study of the floating endarterial graft].

The use of a floating graft is proposed in order to attempt resolution of surgical problems raised by distal internal carotid artery lesions located high in the neck. Surgical treatment is essential, but vascular suture is impossible below the petrosa and ligature of internal carotid artery is often the only solution. The floating graft, which is fixed proximally only and is allowed to float in the circulation, allows exclusion of the lesion and maintenance of the carotid vascular axis. Preliminary experimental studies in the rat have provided satisfactory results and research should be continued in larger animals prior to possible clinical use.

Animals↗
PubMed1984

[Acquired cerebral toxoplasmosis: 3 anatomoclinical cases].

Clinical and pathological findings in three adults with toxoplasmosis of the central nervous system are reported. Symptoms and signs in the first patient, a Haitian woman who had lived in France for 2 years, were suggestive of a right hemispheric space-occupying process. The second case was a woman treated for Hodgkin's disease who showed symptoms and signs of a meningoencephalitis. The presenting lesion in case 3 mimicked a tumor of the posterior fossa. Analysis of these 3 cases and of those previously reported underlines: 1) diagnostic difficulties, particularly in immunodepressed patients; 2) the effectiveness of immunoperoxidase for pathological diagnosis; 3) the poor prognosis due to absence of a specific treatment.

Adolescent↗
PubMed1983

Ocular bobbing: abnormal eye movement or eye movement's abnormality?

Ocular bobbing is classified as an abnormal eye movement, resulting from pathological neuronal activity of the brain stem after bilateral pontine lesions. Clinical oculographic study of 5 patients suffering from ocular bobbing shows that upwards voluntary eye movements are abnormal. We suggest that ocular bobbing should not to be regarded as an abnormal eye movement, but, rather, as the only residual movement of patients which are totally deprived of both horizontal and upward movements.

Arterial Occlusive Diseases↗
PubMed1983

[Anterior choroidal artery syndrome. Clinical and computed tomography study of 4 cases].

The author choroidal artery syndrome is a rare disorder associating, in its complete form, a hemiplegia, a hemianesthesia, and a homonymous lateral hemianopia. Four cases are reported in which the diagnosis was confirmed by a CT scan, which demonstrated a low density area in the posterior part of the posterior limb of the internal capsule, sparing the thalamus medially, and extending laterally to the apex of the pallidum thus corresponding to the area supplied by the anterior choroidal artery. The incomplete forms of this syndrome and clinicopathological correlations are discussed.

Aged↗
PubMed1983

[Contribution of the right hemisphere to language in aphasic patients. Disappearance of this language after a right-sided lesion].

Assessments vary as to the contribution of the right hemisphere to language in aphasic patients. Results of a clinicopathologic study in two right-handed subjects with aphasia are reported. The lesions involved the territories of the left middle and anterior cerebral arteries. Oral productions in one case, studied during the three weeks of survival, were limited to automatic series, recitation of a fable, and completion of sentences. Follow-up in the other case was possible during 2 years of language rehabilitation. At the end of this period, repetition of an echolalic type was possible; a propositional expression had appeared, reduced to substantives and verb infinitives; denomination was possible but rich in semantic paraphasias. A second infarction in the right sylvian region caused the recovered language to disappear and to be replaced by an abolition of all communication. Proof was thus obtained that the progress accomplished was dependent on the right hemisphere. These findings are discussed in the light of observations of patients following left hemispherectomy and of the capacity of the right hemisphere to generate language as demonstrated in patients after commissurotomy. A dynamic interpretation of the taking over of expression by the right hemisphere during some aphasias is proposed.

Aphasia↗
PubMed1982

[Fischer's "one and a half" syndrome: associated paralysis of horizontal eye movements and anterior internuclear ophthalmoplegia: report of 5 cases (author's transl)].

Five cases of Fischer's "one and a half" syndrome are reported. A complex central ophthalmoplegia provokes paralysis of horizontal eye movements on the affected side in both eyes and an internuclear ophthalmoplegia on the same side. No horizontal movement, except in convergence, is possible in the eye on the affected side, the other eye exhibiting movement between the median line and abduction only. Three patients with this syndrome were examined by oculography. The outcome was fatal in one case, pathological examination demonstrating widespread damage to half the pontine protuberance. In another case scanner imaging showed a paramedian protuberential lesion. The syndrome is most frequently observed in multiple sclerosis and cerebrovascular accidents but may follow any lesion in this region. Physiopathological features of the disorder are discussed.

Adolescent↗