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D Henderson

Publications and source records attributed to D Henderson.

At least 199 records · Page 11Linked to original sources
PubMed1987

Cytoskeletal association of pp60src. The transforming protein of the Rous sarcoma virus.

Immunoferritin labelling methods have been employed to examine the distribution of the Rous Sarcoma virus (RSV)-transforming protein pp60src in the detergent-resistant cytoskeleton of transformed cells. pp60src was found to be localized on actin microfilaments present in adhesion plaques, at adherens junctions between cells and also in microfilament bundles. This localization is consistent with the hypothesis that some of the morphological effects of transformation result from the interaction in situ of pp60src with microfilament-bound target proteins.

Actin Cytoskeleton↗
PubMed1987

Aromatase inhibitors: their biochemistry and clinical potential.

It has been proposed that one of the endocrinological factors in the pathogenesis of benign prostatic hyperplasia is estrogen stimulation of stromal growth. Current clinical experience with anti-estrogenic compounds indicates that, in the case of mammary carcinoma, aromatase inhibitors provide a viable alternative to estrogen receptor antagonists for treatment of the disease. It is proposed that inhibitors of estrogen biosynthesis could likewise provide a non-invasive therapy for benign prostate disease. Some aspects of the activity of known aromatase inhibitors as substrates for enzymes of steroid metabolism and their potential relevance to the pharmacology of the compounds are discussed.

17-Hydroxysteroid Dehydrogenases↗
PubMed1987

Evoked response 'forward masking' patterns in chinchillas with temporary hearing loss.

Evoked response "forward masking" data were measured from the inferior colliculus of the chinchilla before and during a temporary threshold shift. The hearing loss was induced by a 2 kHz pure tone of 85 dB SPL presented from 5-8 days. The exposure elevated thresholds by approximately 35 dB at the mid frequencies, but had no effect on low frequency hearing. The exposure also altered the time course of the evoked response forward masking data. Time constants fitting the forward masking data increased by up to a factor of three at the frequency with the greatest loss, but remained within normal limits at the low frequencies where hearing was normal. The increase in the forward masking time constants became most noticeable once the hearing loss exceeded 25 dB. These physiological results are consistent with psychophysical forward masking data from hearing impaired listeners.

Adaptation, Physiological↗
PubMed1987

Synergistic interactions of noise and other ototraumatic agents.

The following is a review of the literature on interaction of noise and other agents, both ototraumatic and nonototraumatic. A short description of the anatomical effects of exposure to intense sound previews the interaction literature. The effects of exposure to combinations of continuous and impulse noise are discussed. This is followed by a review of data on interactions of noise and ototoxic drugs and noise and whole-body vibration, including discussion of putative mechanisms of synergism. In addition, preliminary results of noise-cisplatinum interaction are presented which suggest that if cisplatinum is presented during noise exposure in dose schedules simulating human chemotherapy schedules, hearing threshold shifts and histological damage is much greater than that caused by either agent in isolation. The clinical relevance of the interactions is discussed, along with potential synergistic interactions not yet investigated.

Aminoglycosides↗
PubMed1987

Detection of blood group antigens in frozen sections of prostatic epithelium.

The detection of blood group antigens (BGA) in non-malignant prostates by previous workers has been at best inconsistent. BGA have not before been detected in prostatic carcinomas. In this preliminary study, a variety of anti-BGA reagents, with known specificities that involve the carbohydrate backbone in addition to the BGA specific terminal monosaccharides, were used to study the expression of the A and H (O) BGA in cryostat sections of 16 patients with benign prostatic disease and nine with prostatic cancer. Positive staining, appropriate to the patients' blood group, was seen in all of the benign tissues when anti-BGA reagents that included specificity against type 2 backbone structures were used. Staining was absent, however, if the reagent had only type 1 specificity. The anti-A and anti-H (O) reagents which gave the best staining patterns in benign tissues were used in malignant tissues. No cancer was found to express A antigen but eight of the nine prostatic cancers were positive for the H (O) antigen irrespective of blood group. Using fresh frozen material and appropriate reagents, BGA may be reproducibly detected in the epithelium of all non-malignant prostates, suggesting that a significant component of BGA is probably lipid-based on type 2 carbohydrate backbone chains. Further studies of changes in BGA expression in prostatic cancer are warranted.

ABO Blood-Group System↗
PubMed1986

Studies on the mechanisms of action of progesterone antagonists.

Antigestagens of RU-38.486-type were investigated in different pregnancy models reflecting either "endometrial" or "myometrial" effects. All antigestagens were found effective inhibitors of nidation in guinea pigs. This was evidence for a role of embryonic progesterone in the earliest events of nidation. No comparable inhibition could be obtained by ovariectomy. A more complex pharmacology was found around day 43 p.c. when the abortion was brought about by expulsion. RU-38.486 had marginal activity only. Antigestagens with reduced anti-glucocorticoid activity tended to induce abortions more effectively and faster. Some antigestagen-prostaglandin combinations were found of extreme abortifacient activity. Surprisingly it seemed that anti-glucocorticoid properties in addition to (or rather than) antigestagenic activities bring about this synergism with prostaglandin. The employed guinea pig model for pregnancy termination thus characterized two types of antigestagens: ideal ones for monotherapy or combined use with prostaglandin, respectively. Antigestagens induced a highly sensitive myometrium to prostaglandin-stimulation (Sulprostone) and a marked softening and dilatation of the cervix. Antigestagens perfectly prime the genital tract for oxytocic stimuli, they do not overcome the arrested uterine prostaglandin-secretion of the pregnant uterus at the same time.

Abortifacient Agents, Steroidal↗
PubMed1986

Aromatase inhibitors and benign prostatic hyperplasia.

A growing amount of evidence implies that estrogens may play a role together with androgens in the genesis of benign prostatic hyperplasia (BPH) in man. We review here some of this evidence together with advances made in characterizing inhibitors of estrogen biosynthesis (aromatase inhibitors). It is proposed that aromatase inhibitors may find application in non-surgical treatment of BPH.

Androstenedione↗
PubMed1986

Impulse noise: critical review.

A review of the last 10 years of research on impulse noise reveals certain insights and perspectives on the biological and audiological effects of exposures to impulse noise. First, impulse noise may damage the cochlea by direct mechanical processes. Second, after exposure to impulse noise, hearing may recover in an erratic, nonmonotonic pattern. Third, even though the existing damage-risk criteria evaluate impulse noise in terms of level, duration, and number, often parameters such as temporal pattern, waveform, and rise time are also important in the production of a hearing loss. Fourth, the effects of impulse noise are often inconsistent with the principle of the equal energy hypothesis. Fifth, impulse noise can interact with background continuous noise to produce greater hearing loss than would have been predicted by the simple sum of the individual noises.

Animals↗
PubMed1986

Expression of blood group antigens in urinary tract tumours: prospective fluorescence study using cryostat sections of fresh frozen tissues.

Cryostat sections of fresh frozen tissues were used in a prospective study of blood group H and A antigen fluorescence in 73 transitional cell carcinomas of the bladder. The aim was to evaluate antigen expression without subjecting the tumour tissues to organic solvents that extract blood group active glycolipids. Deletion of the genetically predicted antigen was twice as common in tumours of pT1 or greater stage than those of pTa stage and also twice as common in poorly differentiated than in moderately well differentiated tumours. The considerable heterogeneity and overlap, however, in patterns of reactivity in tumours of various histopathological stages and grades and the effect of secretor status on antigenicity meant that there was no obvious antigenic feature that correlated precisely with invasive stage or differentiation grade. It remains to be determined whether the antigen positive and antigen negative tumours represent different disease entities with differing clinical courses. Our results indicate, however, that studies of the blood group antigens in urinary tract tumours are more likely to be of value in research into biochemical disorders in the neoplastic process than in routine clinical assessment as a guide to treatment.

ABO Blood-Group System↗
PubMed1986

Estrogen replacement therapy in the patient treated for endometrial cancer.

Adenocarcinoma of the endometrium is considered to be an estrogen-dependent neoplasia and as such, hormone replacement therapy is said to be contraindicated. The authors are unaware of any data to substantiate that statement. Patients, who had completed their therapy for stage I carcinoma of the endometrium, were placed on estrogen hormone replacement therapy in a nonrandomized fashion. Between 1975 and 1980, 221 patients with stage I adenocarcinoma of the endometrium were managed at the Duke University Medical Center. Forty-seven patients received estrogen after their cancer therapy, whereas 174 patients did not. Risk factors for recurrence were similar between the two groups. After controlling for these known risk factors, the estimated distributions of time to recurrence for the two groups were significantly different (P less than .05), with the estrogen group experiencing longer disease-free survival. The history of endometrial cancer does not appear to be a contraindication to hormone replacement therapy in patients with stage I disease.

Adenocarcinoma↗
PubMed1986

Propetamphos pour-on formulation for the control of lice on sheep: effect of lice on weight gain and wool production.

Infestation of sheep with the biting louse Damalinia ovis is a potentially serious problem which can effect the quality and quantity of wool produced and may reduce weight gains. In this trial treated sheep produced 34 per cent more wool than louse-infested controls and the wool from the treated sheep was of a better quality. The mean liveweight gain in the treated groups was 18 per cent more than that in the untreated group. Treatment with a pour-on formulation of propetamphos at 25 to 50 mg kg-1 gave more than 99 per cent control of lice and protected against reinfestation for four months.

Administration, Topical↗
PubMed1986

Gout.

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Gout↗
PubMed1985

The impact of legal medicine education on medical students' attitudes toward law.

Physicians' negative attitudes toward law and the legal system derive in part from the physician's lack of understanding of basic legal principles relating to medical practice. Required legal medicine education at the medical school level offers a vehicle for changing these attitudes while at the same time clarifying physicians' rights and responsibilities under the law. The authors in this study assess the impact of required curriculum programming in legal medicine at Southern Illinois University School of Medicine on medical students' attitudes toward law and the legal system. A total of 80 students completed a survey instrument prior to and immediately following required instruction in legal medicine. This instrument enabled the authors to gather information regarding students' attitudes toward law and the legal system as well as students' perceptions of ther medical/legal knowledge. The results suggest that legal medicine education has a favorable impact on the attitudes of medical students toward law and the legal system.

Attitude of Health Personnel↗