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Biomedical subjects

D Heller

Publications and source records attributed to D Heller.

At least 91 records · Page 5Linked to original sources
PubMed1981

Genetic and phenotypic correlations between immune response to Escherichia coli and to Newcastle disease virus vaccines.

Genetic and phenotypic variation and covariation in immune response to inactivated Newcastle disease virus (NDV) vaccine and to Escherichia coli vaccine were studied in commercial poultry strains. Within any given experiment there was no tendency for individual birds to respond in a correlated manner to NDV and E. coli vaccines. There were highly significant differences between sire families in immune response to NDV vaccine (57 sire families) and to E. coli vaccine (35 sire families). Heritabilities of immune response levels to NDV and to E. coli were .41 and .25, respectively. In both cases, additive genetic standard deviations were slightly over 1.0 titer unit. The correlation between sire-family means for response to NDV and sire-family means for response to E. coli (35 sire families) was .077 and statistically nonsignificant. Thus, the data provide evidence for the presence of significant genetic variation in immune response with respect to two endemic disease antigens, but they provide no evidence for a genetic correlation in response to the two antigens.

Animals↗
PubMed1981

Traumatic head injury: restlessness and agitation as prognosticators of physical and psychologic improvement in patients.

Eighty-seven traumatic head injury patients were followed from admission to post-discharge, spanning a period of 5 years or more. Using objective criteria, post-traumatic activity level (PTAL) was evaluated on admission and compared with cognitive and overall status at discharge. Further comparisons were made with follow-up data. Twelve patients were agitated., 32 restless, 17 appropriately active, 16 sluggish, and 10 immobile. Eighty-three percent of the agitated, 84.3% of the restless, 70.6% of the appropriately active, 18.8% of the sluggish, and 10% of the immobile patients showed improvement. At discharge, 41.6% of the agitated and 42.4% of the restless patients also needed supervision. Improvement was related to PTAL, with appropriately active restless patients demonstrating the greatest overall return of function. Rehabilitation of sluggish and immobile patients was not as dramatic. The majority of patients were able to return to the community; however, agitated patients showed a tendency to be committed for psychologic reasons to alternative medical facilities. Long-term improvement is also related to PTAL. At discharge, restlessness and agitation is related to improved physical functioning and inversely related to psychological adjustment. During follow-up, the appropriately active and the restless patients showed the greatest tendency to becoming cognitively functional.

Adaptation, Psychological↗
PubMed1977

Polyacrylamide gel as a medium for DNA dissociation and reassociation.

Several properties of thermal denaturation and renaturation of DNA in polyacrylamide gels were investigated: (1) Following electrophoresis the DNA band was scanned and shown to increase in absorbance with increasing temperature. The increase was proportioned to DNA concentration across the peak. (2) The dependence of the Tm on salt concentration over a hundred fold range was similar to that found for DNA in free solution. (3) Denaturation of several DNA samples ranging in G + C content from 26 to 71% was compared in gels and free solution. The relationship between Tm and % G + C was virtually identical for both sets of DNAs. (4) The kinetics of DNA renaturation in the gel was followed. Reassociation of bacteriophage T4 DNA was 2nd order and proceeded more rapidly in polyacrylamide gels than in free solution.

Acrylamides↗
PubMed1977

Regional services for children and youth with diabetes.

A regional diabetes program for children and youth comprising outreach clinics, frequent routine and emergency telephone contact, and a camping program was developed within the State Children's Medical Services (Crippled Children's) Program. The pediatric nurse specialist in diabetes served as the pivotal professional in the education and supervision of patients. Cost benefit was calculated from estimated hospital days prevented based on average length of admissions at diagnosis (14 days) and hospital days in the year prior to referral of those with established diabetes. During the first year 369 hospital days were prevented, for an estimated savings of $65,000; the second year 547 hospital days were avoided, a value of $96,000. Total annual program costs to the state and private patients (including camp fees) were $36,000. Although hospital costs are an apparent and useful reference to justify funding, the main value of the program must be in the prevention of secondary physical and emotional disability. This requires continuous commitment and availability of persons who know the patient and family, who can interpret information related to metabolic control of diabetes, and who are able to influence the family and community to respond appropriately to the youngster's needs.

Adolescent↗