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Biomedical subjects

D Heldenberg

Publications and source records attributed to D Heldenberg.

At least 37 records · Page 2Linked to original sources
PubMed1988

Studies of manometric abnormalities of the rectoanal region during defecation in constipated and soiling children: modification through biofeedback therapy.

Anorectal manometry was performed on 12 normal children and 18 patients suffering from constipation and soiling. In both groups, the results of the rectoanal inhibitory reflex and the squeezing anal pressure were similar. The pressure recording in all the normal children showed that the anal canal relaxed during defecation. Fourteen (78%) constipated children closed the anal canal while straining by contracting the anal sphincter. This paradoxical contraction appears to be the cause of chronic constipation. Twelve children with paradoxical anal closure were treated by biofeedback therapy. The results show that all these children were successfully conditioned to relax their anal sphincter during defecation. This therapy improved their bowel habits and relieved them from constipation and soiling. It is proposed that the paradoxical anal closure itself is the result of a self-conditioning process. In this process, the patient learns to paradoxically contract the external anal sphincter in response to the urge and the act of defecation. Biofeedback therapy seems to be the appropriate treatment in such cases.

Anal Canal↗
PubMed1983

Serum lipids and lipoprotein concentrations in women with rheumatoid arthritis.

Serum lipid and lipoprotein concentrations were measured in 51 women with rheumatoid arthritis treated with both nonsteroidal and steroidal drugs and compared to a group of women with rheumatoid arthritis not receiving anti-inflammatory drugs and to a healthy control group. Significantly lower concentrations of total cholesterol and low density lipoprotein cholesterol were found in the rheumatoid patients on nonsteroidal or steroidal anti-inflammatory drugs, while no difference was found in high density lipoprotein cholesterol and triglycerides. In the group of rheumatoid patients who received no nonsteroidal or steroidal anti-inflammatory drugs, the triglyceride level was higher than in the control group, and that of HDL-C was lower. Total cholesterol and LDL-C levels were higher in the patients not on anti-inflammatory drugs than in patients receiving anti-inflammatory drugs. The results of this study suggest that hyperlipidemia is not one of the predisposing factors for coronary disease in patients with rheumatoid arthritis receiving anti-inflammatory therapy. Anti-inflammatory drugs may play a role in the regulation of serum lipids in patients with rheumatoid arthritis.

Adult↗
PubMed1983

Breast milk and adipose tissue fatty acid composition in relation to maternal dietary intake.

The fatty acid (FA) relative concentration (g/100g) of human milk triglyceride (TG) was compared to that of adipose tissue (AT). A high concentration of linoleic acid (C-18:2) was present in AT, probably reflecting long term high linoleic acid dietary intake. Linoleic acid was slightly lower in colostrum and transitional milk. No difference in C-18:2 relative concentration was seen between AT and human milk obtained 6 weeks post-partum. Marked short-term dietary modification in linoleic acid intake of the mother, 6 weeks post-partum, did not result in changes in C-18:2 relative concentration of human milk. In spite of measured marked intradiurnal variability in C-18:2 intake, human milk TG FA relative concentration remained remarkably constant. It is suggested that human milk TG FA composition reflects, mainly, the composition of AT. With the increased dietary intake of polyunsaturated fat in many populations, high levels of linoleic acid in human milk are to be expected. The intake of this fatty acid may exceed the suggested daily allowance and thus cause harmful effects, particularly in preterm infants.

Journal Article↗
PubMed1983

The effect of chronic anticonvulsant therapy on serum lipids and lipoproteins in epileptic children.

We measured serum lipids and lipoproteins in 33 epileptic children who were treated with phenobarbital, valproate, and carbamazepine. High-density lipoprotein cholesterol (HDL-c) was significantly higher in the epileptic children than in two control groups: healthy nonepileptic children, and epileptic children before starting anticonvulsant therapy. Our findings indicate that anticonvulsant drugs should be added to the list of substances that affect serum HDL-c.

Adolescent↗