The levels of unsulfated, free or conjugated cholic, deoxycholic and chenodeoxycholic acids were measured using gas chromatography in 39 humans free of hepatic or intestinal diseases before and 10, 60, 120 and 180 min after ingestion of a standard meal. The probable maximal levels were determined with an error risk lower than 0.05. In fasting subjects, the observed values are comparable with those obtained by other authors working with gas chromatography or radioimmunoassay. Meal ingestion does not influence in the same way the serum levels of the various bile acids: the chemodeoxycholic serum level rose significantly in all cases whereas cholic and deoxycholic serum levels rose only in two-thirds of observed subjects; 60 and 120 min after the meal for chenodeoxycholic acid, and only 60 min after the meal for cholic acid, the mean values are significantly higher than the fasting ones; 120 min after the meal, the chenodeoxycholic and total bile acid probable maximal levels (respectively 7.4 and 10.3 micrometer) are twice the fasting ones. The cholic to chenodeoxycholic serum level ratio is nearly always lower than 1 but may reach 3. On the basis of these results, the validity and efficacy of the exploration tests based on serum bile acid level determinations are discussed.

Adolescent↗

PubMed1976

[Latent bone lesions in divers. Comparison of results in a survey of 105 divers and 105 control subjects].

The results of a systematic radiological study of the shoulders and hips of 105 naval divers are reported and compared with those of recorded during a comparative study carried out in non-diver control subjects of a similar age. Almost half the divers had small bone lesions such as dense islets or bordered geodes. These appeared more frequently in divers than in the controls. Their precise natur remains hypothetical, in the absence of histological criteria, but it is possible at least for the bordered geodes, that they represent tiny centres of osteonecrosis.

Adult↗

PubMed1974

[Polyarthritis preceding viral hepatitis].

Explore the source record for details and available documents.

Adult↗

PubMedDate not supplied

[Bone localizations disclosing Hodgkin's disease. Apropos of 11 cases].

The authors report 11 cases of Hodgkin's disease in which the first sign was due to bone involvement. Such observations are rare and raise diagnosis delays (Means: 5, 6 months in this series). Modern medical imaging techniques (scintigraphy, CT scan, magnetic resonance imaging) are very useful to an earlier diagnosis which will be better confirmed by lymph node biopsy given the poor information yielded by osseous cytology and/or histology. The elective localisation in bones belonging to the axial skeleton seems to support the hypothesis of a contiguous osseous involvement from lymphoïd organs in contact with bones. Evolution with chemotherapy and radiotherapy is very similar to that observed in patients without bone involvement.

Adolescent↗

PubMedDate not supplied

[Immunologic thrombopenic purpura and HIV infection in heroin addicts].

The authors have studied the clinical aspects and mechanism of the thrombocytopenia observed in heroin addicts in the light of recently published data. This relatively frequent complication of intravenous drug addiction must be related to the immunological disturbances caused by carriage of the HIV virus. The evolutive characteristics of thrombocytopenia in such cases and the therapeutic implications of this association between thrombocytopenic purpura and acquired immunodeficiency are discussed.

Acquired Immunodeficiency Syndrome↗

PubMedDate not supplied

[Consumption coagulopathy in adenocarcinomas. Report of seven cases (author's transl)].

The authors present 7 cases of disseminated intravascular coagulation (DIC), 4 of them with hemorragic syndrom, with appeared in the course of different adenocarcinomas (prostatic, pancreatic or undeterminated). Emphasis is set on 2 points : -- in all cases, metastasis of these cancers can be found in the bone marrow and/or the liver ; -- DIC may be the first sign of the disease. The pronostic is very bad, even with heparinic therapy because of the lack of specific treatment but for prostatic cancer.

Adenocarcinoma↗

PubMedDate not supplied

[Plasmacytoma of the head of the pancreas: a rare cause of cholestatic jaundice].

A case of plasmacytoma of the head of the pancreas in a 75-year-old woman, revealed by obstructive jaundice, is reported. The tumor, which compressed the main bile duct, appeared to be round on sonographic and endoscopic retrograde cholangiographic investigations. Sonographically guided needle biopsy was performed but led to the erroneous diagnosis of pancreatic adenocarcinoma. Choledochojejunostomy and gastrojejunostomy were then performed but the patient died 10 days after the operation. Pathological examination of the specimens obtained at autopsy showed that the pancreatic tumor (as well as an other osseous lesion) were plasmacytomas with cells containing G immunoglobulins of the lambda type. Despite the failure of needle biopsy to lead to correct diagnosis in this case, the potential value of this method remains unequivocal as reported previously. Indeed, when positive results are obtained by this method in visceral localizations of plasmacytoma, hazardous surgery may be avoided and radiation and/or chemotherapy may be chosen preferentially.

Aged↗

PubMedDate not supplied

[Chronic lymphocytic leukemia, acute anergic tuberculosis, multiple caseous adenitis (author's transl)].

The authors report an exceptional case of hematopoietic tuberculosis complicating a chronic lymphocytic leukemia, developing at first an acute tuberculous septicemia then a caseous disease of lymph glands. The usual difficulties of the diagnosis were increased by the underlying blood disease and it was done mainly thanks to an osteo-medullary biopsy and to the results of the specific proof treatment.

Aged↗

PubMedDate not supplied

[Retroperitoneal extragonadal germ cell tumors: apropos of 4 cases. The importance of research of an occult testicular lesion].

In the absence of palpable testicular tumor one often retains the primitive character of an extragonadal germ-cell tumor with retroperitoneal localization. This motion must be reconsidered in front of the occasionally late discovery of the scrotal origin of those lesions. The usefulness of testicular sonography in the revelation of infra clinical lesions is now perfectly well admitted. Concurrently, testicular biopsies can provide the notion of carcinoma in situ and its links with the retroperitoneal germ-cell tumor must be indicated precisely. The four related observations allow us to stress on the seriousness of this affection which often remains tardily diagnosed. The specific treatment of the testicular lesion, when it is put into evidence, turns out to be absolutely necessary.

Adult↗