Binding of radioactive oligonucleotides to ribosomes.
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Adenosine Diphosphate↗
Biomedical subjects
D Hatfield
Publications and source records attributed to D Hatfield.
Transfer RNA specificity in mammalian tissues and codon responses of seryl transfer RNA.
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Animals↗
Seryl-tRNA in mammalian tissues: chromatographic differences in brain and liver and a specific response to the codon, UGA.
Differences in the elution profiles of seryl-tRNAs of beef and of rabbit liver and brain were observed. A species of beef seryl-tRNA obtained by reversed phase column chromatography that responds specifically to the codon UGA was found. In addition, a species of rabbit and of chicken seryl-tRNA that recognizes UGA was found.
Animals↗
Nonsense mutations in the maltose A region of the genetic map of Escherichia coli.
The isolation of one amber mutation in malQ, one ochre mutation in malP, and seven amber mutations in malT is reported. A study of their phenotypic expressions in the presence of the amber suppressor su(III) and the ochre suppressor su(c) suggests that (i) malQ is the structural gene for amylomaltase; (ii) malQ and the structural gene for maltodextrin phosphorylase, malP, belong to the same operon; (iii) the malT product, which promotes the expression of the malP-malQ operon, is a protein synthesized in limiting amounts by the wild-type strain.
Chromosome Mapping↗
Genetic analysis of the maltose A region in Escherichia coli.
The genetic map of the maltose A locus of Escherichia coli contains at least three closely linked genes, malT, malP, and malQ. The order of these genes is established by deletion mapping. MalP and malQ, the presumed structural genes for maltodextrin phosphorylase and amylomaltase, belong to the same operon. MalT may be a regulator gene involved in the positive control of this operon.
Chromosome Mapping↗
The RNA code and protein synthesis.
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Alanine↗
Oligonucleotide-ribosome-AA-sRNA interactions.
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Amino Acids↗
Is social drinking during pregnancy harmless?
The last 10 to 15 years have provided a growing body of evidence that demonstrates a distinct relationship between excessive alcohol consumption during pregnancy and birth defects. In light of this voluminous quantity of research, no responsible health professional or researcher would deny that alcohol can cause fetal abnormalities if consumed chronically and in large quantities. However, close examination of the literature does not support the no threshold corollary--that is that any amount of alcohol will have a detrimental effect on the fetus. At present, it appears that only those women who consume large amounts of alcohol on a chronic basis are at risk of giving birth to children with fetal alcohol syndrome (FAS) and its associated anomalies. Prevention should be aimed at this group of women. Blanket warnings and recommendations for total abstinence may serve little purpose other than to instill unnecessary fear, anxiety and guilt in those women at little or no risk while having no affect on the real target audience; the chronic heavy drinkers.
Abnormalities, Drug-Induced↗