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Biomedical subjects

D Harms

Publications and source records attributed to D Harms.

At least 199 records · Page 11Linked to original sources
PubMed1981

[Histopathology of nephroblastomas (author's transl)].

Nephrectomy specimens from 42 patients with nephroblastoma were investigated. With the exception of one specimen (the patient had been treated preoperatively), all of the tumors were suitable for grading procedures. When the tumors were classified by the grading procedure of Lawler et al. (1975), the moderately tubulus-rich type++ was the most common (22 out of 41 patients). When the classification of Beckwith and Palmer (1978) was applied, the mixed type of nephroblastoma dominated correspondingly (19 out of 41 patients). Patients with an increased risk can be identified particularly well with the classification of Beckwith and Palmer. The following histologic features are indications of an unfavourable prognosis: focal or diffuse "anaplasia" of the tumor tissue, or a sarcomatous component in a stroma-rich nephroblastoma. The children with sarcomatous nephroblastoma (5 patients) were remarkably young (the oldest was 16 months of age), whereas the children with anaplastic nephroblastoma (3 patients) were much older (62, 67, and 72 months). In five children equivalents of the nephroblastomatosis complex (nodular renal blastema in all 5 patients, sclerosing metanephric hamartoma in 2 patients, and Wilms' tumorlet in one patient) were found in the non-infiltrated tissue of the same kidney.

Age Factors↗
PubMed1981

[Intraosseous lipomas (author's transl)].

This is a report on four intraosseous lipomas. One in the tibia diapysis of an infant, one in the fibula head, one in the proximal epimetaphysis of the humerus, and one in the calcaneus of three adults. Together with fourty-two intraosseous lipomas which have been reported by other authors, they are evaluated via clinical, radiological, and pathological aspects. The metaphyses of long bones and the calcaneus are common localizations of intraosseous lipomas. There may be no clinical symptoms or non-specific ones. The history may last for decades. Trabecular structures are noted usually on x-ray and almost always on histological examination. A capsule, capillaries, and the lack of sinusoids and haemopoietic bone marrow demonstrate the neoplastic nature of intraosseous lipomas. Because of their good prognosis intraosseous lipomas may be treated conservatively or by curettage.

Adult↗
PubMed1981

Influence of the beta-blocking atenolol and other medications on visual reaction time.

Visual reaction time as a measure of vigilance and of the psychophysiological condition of subjects, was determined after combined physical and mental stress to examine the influence of beta blockade. Using the technique of electro-oculography, 40 subjects aged 25.7 +/- 6 years, with a mean blood pressure of 126/79 torr, were studied in a double-blind crossover design after application of placebo or 50 mg atenolol for 3 d. Visual reaction time was defined as the time between display of a peripheral light signal and the start of the eye movement that shifts the direction of gaze from the reference point to the stimulus. The results of the study show that, under these experimental conditions, there is a positive effect of beta blocker medication on vigilance. Findings of other authors are discussed. To prove the sensitivity of the test method in a preliminary study, the effects of the well-known drugs fenethylline-hydrochioride, diazepam, oxazepam, and alcohol on visual reaction time were investigated.

Adult↗
PubMed1980

Fetal rhabdomyomatous nephroblastoma. Pathologic histology and special clinical and biologic features.

Fetal rhabdomyomatous nephroblastoma is a very rare variant of Wilms' tumor. The special clinical and histologic features of this variant are presented on the basis of a case seen in a boy who was 13 months old at nephrectomy 8 months ago and has remained healthy since then. The tumor chiefly consists of fetal striated muscle; it occurs predominantly in infancy and early childhood and is often bilateral. Angiography shows a relative paucity of vessels. The volume of the tumor (determined by ultrasonography) decreases only slightly after preoperative radio- and chemotherapy because of a predominance of mesenchymal structures. The finding of nodular renal blastema in renal parenchyma with an apparently normal gross appearance is an argument in favor of classifying this type of tumor in the group of nephroblastomas and may explain the tendency of fetal rhabdomyomatous nephroblastoma to occur bilaterally.

Humans↗
PubMed1979

[Alpha-1-fetoprotein in tumour tissue (author's transl)].

Using the indirect immunoperoxidase method, alpha 1-fetoprotein (AFP) can be demonstrated in paraffin sections of tumours by light-microscopy. Among 160 tumour preparations it was demonstrated in five of six endodermal sinus tumors, 19 of 40 teratomas, the three hepatoblastomas and 9 of 16 primary liver-cell carcinomas. Among 15 rhabdomyosarcomas, 15 Wilms tumours, 15 neuroblastomas and 15 other malignant tumours only one rhabdomyosarcoma contained AFP. No AFP was demonstrated in 35 various benign tumours and various other human tissue samples. Distribution of AFP-producing cells in tumour tissue is generally focal samples. In malignant teratomas AFP was found only in areas which corresponded to an endodermal sinus tumour or an embryonic carcinoma. The practical significance of the results consists of (1) demonstration and localisation of AFP in tumour tissue; (2) aiding the differential diagnosis and classification of tumours and their metastases; and (3) recognition of pathogenetic connection between embryonic carcinoma and endodermal sinus tumour.

Carcinoma, Hepatocellular↗
PubMed1979

[Grading procedures for neuroblastoma (author's transl)].

Various procedures of practical significance for grading neuroblastoma are described. The comparability of the grading procedures was studied on the basis of a series of 75 cases of neuroblastoma. When the grading procedure of Hughes et al. was applied to the material collected at the Childhood Tumor Registry in Kiel, the proportions of the various grades of malignancy agreed with the data on the collection in Manchester. More than 50% of the cases of neuroblastoma were undifferentiated, corresponding to grade III. An anaplastic type of neuroblastoma is also described. When applying grading procedures, one has to take the possible variations in the histologic picture of neuroblastoma into consideration.

Brain Neoplasms↗
PubMed1978

Osteogenic sarcoma complicating osteogenesis imperfecta tarda.

We describe the case history of a 13 years old boy who developed osteogenic sarcoma of the left thigh, six years after diagnosis of osteogenesis imperfecta tarda with a positive family history. Only four other patients with this disease combination are reported in the literature. Preoperative treatment with high-dose Methotrexate caused marked tumor regression, as shown at examination of amputation material. The inter-relationships between the two disorders are discussed and the literature is briefly reviewed.

Adolescent↗
PubMed1978

Argininosuccinic aciduria: metabolic studies and effects of treatment with keto-analogues of essential amino acids.

A 22 years old female with the late-onset of argininosuccinic aciduria was successfully treated for 5 months with a mixture of essential amino acids and their keto-analogues. There was a marked change in plasma ammonia, plasma amino acids and argininosuccinic acid excretion. A long term anabolic response was reflected by an increase of total serum proteins and serum albumin by about 1 g/dl during the first 5 months of treatment. There was a striking improvement in the patient's seizure disorder following institution of the keto-analogue therapy.

Adult↗
PubMed1978

Protein load in argininosuccinic aciduria: thoughts on its biochemical implications.

A patient with argininosuccinc aciduria was charged with 50 grams of protein, which was followed by considerable hyperammonemia. There was no response in further urea formation; but there was a considerable production of orotic acid, a precursor of pyrimidines. This makes orotic acid to an important diagnostic tool for the diagnosis of impaired urea formation. The patient's plasma amino acid pattern led to the suggestion that orotic acid synthesis is initiated by increased de novo formation of carbamyl phosphate in the cytosol and not by deviation of already existing intramitochondrial carbamyl phosphate.

Adult↗
PubMed1978

[Inguinal Wilms' tumor (author's transl)].

Case report on a small inguinal Wilms' tumor in a 3-year-old boy. Their is strong evidence, that this heterotopic Wilms' tumor developed in dysplastic renal tissue.

Child, Preschool↗
PubMed1978

[Roentgenographic changes of the skeleton in a case of tuberous sclerosis (morbus Bourneville-Pringle) (author's transl)].

Increasing sclerosis in the thoracolumbar spine has been followed up in a boy suffering from tuberous sclerosis. The earlist abnormality appearing as an irregular density in the radix of the posterior arch of the first lumbar vertebra has been detected at the age of one year. Until the ninth year of life the disease process has involved the vertebral column from T-8 to L-2. During the course roentgenograms revealed several diffuse areas of opacification with ill-defined outlines which tended to merge. As a rule all vertebrae were affected asymmetrically. Neither deformities of the vertebrae nor functional impairment of the axial skeleton have been found. Based on X ray appearance classification of characteristic and accessory bone abnormalities in tuberous sclerosis was discussed.

Bone Diseases↗