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Biomedical subjects

D Hötzel

Publications and source records attributed to D Hötzel.

52 records · Page 3Linked to original sources
PubMed1975

[Urinary excretion of pantothenic acid as a measurement of nutritional requirements].

Several groups of male Wistar-Rats were fed for 15 month with a purified diet containing different amounts of pantothenic acid. The groups received 150, 100, 25 and 0% pantothenic acid of the requirement respectively. A further group was fed without pantothenic acid in the diet but administered with the antagonist omega-methyl-pantothenic acid. The excretion of pantothenic acid in the urine was measured at different times, and a groups specific level of excretion could be established for the different groups. Differences to the controls were highly significant in the test groups after 2-18 weeks. Studies of this type were conducted in order to obtain basic informations for later experiments in human beings.

Animals↗
PubMed1975

[Influencing of acetylation and corticosterone biosynthesis through long-term pantothenic acid deficiency in rats].

The effect of different dietary intake of pantothenic acid (150;100;25 and 0% of the requirement) on the metabolism of rats was studied during 15 months. The ability of the adrenals for synthesis of corticosterone and the rate of acetylation of a sulfonamid (Sulfisomidin) were taken as parameters. The above mentioned parameters were influenced significantly already after two weeks and a pantothenic acid free diet containing the antagonist omega-methyl-pantothenic acid. With a 25% supply of pantothenic acid and without omega-methyl-pantothenic acid it lasted half a year until significant alterations of acetylation could be demonstrated. The synthetic ability of the adrenals for corticosteroids was significantly increased after a year in the 25% group. After the end of the study, this hyperfunctional state was followed by hypofunction, resulting in a significantly reduced ability of synthesis of the glands. Studies of this type were conducted to obrain basic informations for later experiments in human beings.

Acetylation↗