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Biomedical subjects

D H Thompson

Publications and source records attributed to D H Thompson.

At least 55 records · Page 3Linked to original sources
PubMed1977

Investigating the contacts and suspected contacts of tuberculous patients in New Orleans.

The New Orleans Health Department still investigates the contacts and suspected contacts of patients with tuberculosis, although it has stopped some tuberculosis control programs as unproductive. To determine whether contact investigation is worthwhile, in 1974 we sampled 1,110 men, women, infants, and children who had proved (391) or suspected (719) contact with a tuberculous patient. Nineteen percent (215 out of 1,110) of these contacts examined had tuberculous infections (reflected by positive skin tests). Seven (0.63%) also had pulmonary tuberculosis. We concluded that contact investigation effectively identified residents of New Orleans who were at risk of tuberculosis and the program should be continued.

Adolescent↗
PubMed1976

Finding recent tuberculous infection in New Orleans. Results of tuberculin skin tests on New Orleans children from the inner city and Contact Investigation Program.

We tested infants and preschool-age children from the New Orleans Health Department programs for tuberculosis contact investigation and for tuberculin skin testing. About 7.8% (34 of 438) of the contacts and about 0.78% (107 of 13,797) of those given skin tests were tuberculosis-infected. Both programs, we concluded, detected enough recent tuberculous infection to be worthwhile as screening procedures.

Age Factors↗
PubMedDate not supplied

Blindness after bilateral neck dissection: case report and review.

The primary objective of this review of the literature is to identify the probable causes of blindness after bilateral radical neck dissections. This case report and literature review also discusses possible preventive measures that may avert this catastrophic outcome. Cases of blindness after bilateral radical neck dissection were identified by an electronic literature search, as well as cross-checking all references of the above-identified papers. Eleven previous cases of blindness after bilateral neck dissection were identified. The most common cause was posterior ischemic optic neuropathy (PION), which was permanent. We present the only case in the literature in which blindness occurred after radical neck dissections separated by a span of 9 years. The cause of blindness in our patient was posterior ischemic optic neuropathy. Contributing factors included anemia, hypotension, and disruption of collateral venous return from the neck.

Aged↗
PubMedDate not supplied

Cascade liposomal triggering: light-induced Ca2+ release from diplasmenylcholine liposomes triggers PLA2-catalyzed hydrolysis and contents leakage from DPPC liposomes.

We have previously reported a direct triggering approach [Thompson, D. H., et al. (1996) Biochim. Biophys. Acta 1279, 25-34; Gerasimov, O. V., et al. (1997) Biochim. Biophys. Acta 1324, 200-214] based on the facile degradation of plasmenylcholine and diplasmenylcholine vinyl ether linkages by either photooxidation or low-pH environments. This report describes a novel, cascade-type triggering technique that utilizes liposome photooxidation and contents release to activate an enzyme capable of destabilizing conventional phosphatidylcholine liposomes. Our application of this concept employs a mixture of two different liposome populations, one composed of synthetic diplasmenylcholine (1, 2-dihexadec-1'-enyl-sn-glycero-3-phosphocholine, DPPlsCho) containing Ca2+ as a signaling agent for phospholipase A2 (PLA2) and the second composed of 1, 2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC) with encapsulated calcein as the reporter molecule. Bacteriochlorophyll (BChl)-sensitized photorelease of Ca2+ from PLA2-resistant DPPlsCho liposomes activates extravesicular PLA2, thereby promoting catalyzed DPPC hydrolysis in a secondary triggering reaction, leading to calcein release. BChl/DPPlsCho/DHC/DPPE-PEG5000/Ca2+IN (0.5:85:10:5) liposomes can be phototriggered using 800 nm excitation, resulting in Ca2+ release (t50% release = 15 min) that cocatalyzes the release of calcein (t50% release = 40 min) from DPPC liposomes (1.5 mM total lipid in DPPlsCho liposomes, 0.18 mM DPPC, 210 micro M final Ca2+ concentration, 90 units of PLA2/ml, 50 mM calcein, and 36 micro M EDTA). No appreciable calcein release occurs in the absence of either PLA2 or BChl/DPPlsCho/DHC/DPPE-PEG5000/CaIN liposomes. The implications of this cascade triggering technique on drug delivery approaches are briefly discussed.

1,2-Dipalmitoylphosphatidylcholine↗