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Biomedical subjects

D H Scott

Publications and source records attributed to D H Scott.

At least 55 records · Page 3Linked to original sources

Inadequate medical order writing. A source of confusion and increased costs.

Audits of medication and intravenous fluid orders and of return to the pharmacy of unused intravenous solutions were conducted in 1980 at a university teaching hospital in response to a prevailing impression among pharmacists that physicians' orders were often written in an incomplete, nonstandardized fashion and that intravenous fluid wastage was common. A disturbing number of order were incomplete and judged to be ambiguous. Less than 25% of orders for intravenously given solutions contained adequate instructions for subsequent administration of fluids. Intravenous fluid return amounted to an estimated loss of $137,695 per year in wasted material and labor. The results of the audits were disseminated among the staff. In addition, the pharmacy changed its operations to detect more quickly and correct the problems caused by ambiguous orders. Later studies showed a reduction in the return of unused intravenous fluids and some improvement in order writing. Inadequate and ambiguous orders were still judged to be a problem, however, especially intravenous fluid orders that omitted instructions for subsequent fluid requirements and "open-ended" intravenous fluid orders. Such orders were eight times more likely to be associated with return of unused intravenous fluids than orders with adequate instructions for giving fluids subsequently.

Drug Prescriptions↗

Factors influencing survival in bilateral breast cancer.

One hundred and four patients with bilateral breast cancers, detected clinically, were studied. Patients with synchronous lesions experienced the worst survival. Lymph node metastases in the second mastectomy had obvious adverse effect on survival. The development of scirrhous carcinoma in the second breast did not alter survival. A maximum of 21 patients might have been adversely affected by the development of a second cancer because of lymph node metastases in the second breast only. Survivorship data suggest the adequacy of treatment of contralateral breast cancers when they become detectable by clinical means alone.

Age Factors↗

Gastric bypass criteria for effectiveness.

Weight loss patterns and revision rates in three sequential groups of patients with gastric bypasses and loop gastroenterostomies between 1965 and 1978 demonstrate the importance of a 50 ml volume of the upper segment measured at 25 to 30 cm water luminal pressure and a 10 to 12 mm diameter stoma. The need for a secure partition is well known. Reinforcement of the stoma to prevent dilation has contributed greatly to the success of gastroplasty and should be studied in gastric bypass. The importance of quality control and of both revision rate and weight patterns over five to ten years is emphasized.

Body Weight↗

Gastric bypass in morbid obesity.

Gastric operations for the treatment of morbid obesity have been standardized. They require close adherence to specifications for success. The upper stomach volume should be measured intraoperatively and fashioned to a capacity of 50 ml at a pressure of 25 to 30 cm of saline. The outlet should be no larger than 12 mm in diameter. The necessity for bypassing the remainder of the stomach and duodenum has not been established. Early maintenance of gastric decompression and immediate supervision and education of patients regarding new eating habits are crucial in the prevention of gastric rupture. Long-term care is usually minimal, but patients should be followed at least at 6 weeks, 6 months, 1 year, and at yearly intervals thereafter. Increasing numbers of intestinal bypass operations are being replaced by gastric bypass or gastroplasty. Many surgeons who once used intestinal bypass have decided to use the stomach operations instead because of the much less complicated long-term care required after the gastric procedures.

Avitaminosis↗

Deflection of spinal needles by the bevel.

Bevelled spinal needles sizes 22 and 25 gauge were passed through tough meat to assess the influence of bevel orientation on the path of the needle. The needle bent away from the bevel surface by about 1 mm for each centimetre of needle travel through the tissue. With an introducer, the deviation was reduced by a reduction of the distance of unsupported travel. Pencil-point needles were less deviated.

Anesthesia, Spinal↗

Haemodynamic changes following buprenorphine and morphine.

Twenty-five women were investigated on the day after lower abdominal surgery in a single-blind non-cross-over trial to assess and compare the haemodynamic effects of intravenous injections of buprenorphine 0.3 mg and morphine 7.5 mg. Arterial blood pressure was measured by sphygmomanometry and cardiac output by thoracic impedance cardiography. Arterial blood pressure was significantly reduced following both drugs (p < 0.05), although the mean decrease in systolic arterial pressure was less than 8 mmHg. However, in one patient in each group the decrease was more than 20 mmHg. Cardiac output decreased but the mean reduction was less than 5%. The greatest individual decreases were 21% after buprenorphine and 30% after morphine. Myocardial contractility, assessed by systolic time indices, did not appear to change. There were no consistent differences in the haemodynamic effects of the two drugs.

Abdomen↗

Pharmacokinetic and clinical pharmacological studies with mepivacaine and prilocaine.

The tolerance and pharmacokinetic properties of mepivacaine and prilocaine were compared following i.v. infusion of 250 mg (0.88 and 0.97 mmol respectively) of each drug in five healthy volunteers. Side-effects were minor and occurred in only two subjects during the infusion of mepivacaine. Plasma concentrations of mepivacaine were greater in each subject than the corresponding values for prilocaine. The elimination half-life of mepivacaine was generally longer than that for prilocaine, whereas the total body clearance of prilocaine was consistently greater than the corresponding value for mepivacaine. For each subject the clearance of prilocaine substantially exceeded normal heptic blood flow and therefore an extra-hepatic site of metabolism of prilocaine has been postulated.

Adult↗

Cardiovascular effects of prenalterol (H133/22) in normal man.

1 Prenalterol, (S-(-)-1-(4 hydroxyphenoxy)-3-isopropylaminopropanol-2 hydrochloride) a cardio-selective beta-adrenergic receptor agonist, was infused intravenously into six normal male volunteers to determine the cardiovascular effects of this drug. 2 On different occasions, each volunteer received a placebo infusion, an infusion of 0.5 mg prenalterol and an infusion of 1 mg prenalterol. Cardiac output (impedance cardiography), arterial pressure (sphygmomanometry), heart rate and ECG were measured throughout. 3 Prenalterol produced a statistically significant increase in cardiac output and at the end of the infusion this increase was 24% with 0.5 mg and 29% with 1 mg, mainly due to an increase in stroke volume (18% and 17%) with a lesser change in heart rate (+2 and +7 beats/min). Pulse pressure increased but mean arterial pressure showed little change. Peripheral resistance fell by 18% and 20%. As indicated by systolic time indices myocardial contractility increased. 4 Prenalterol at plasma concentrations in excess of 20 nmol l-1 produced significant inotropic effects but did not markedly increase heart rate at concentrations of 60 nmol l-1.

Adrenergic beta-Agonists↗

Gastric bypass for obesity after ten years experience.

Over 625 patients having gastric bypass for the treatment of morbid obesity are currently being followed at the University of Iowa. Many innovations have increased operative exposure, greatly reduced operating time, and improved the effectiveness and safety of the operation. Recent weight figures show that a 55 percent loss of excess weight can be expected. Several comparative studies between gastric and jejunoileal bypass show that gastric bypass, while producing identical weight loss, has few of the many complications such as liver failure, renal and gallstone formation, diarrhea, enteritis, that are commonly associated with jejunoileal bypass. Stomal ulcer occurrence has been only 2 percent. Imporvements in diabetes mellitus and hypertension can be expected with weight loss. Other effects of gastric bypass were determined by use of a questionnaire. It is concluded, by surgeons having experience with both gastric and jejunoileal bypass, that gastric bypass is the treatment of choice for morbid obesity when nonoperative measures fail.

Adult↗

A diathermy suppression filter for external pacemakers.

Some patients undergoing cardiothoracic surgery require cardiac pacing. Surgical diathermy interferes with the operation of external pacemakers, and can cause a loss of cardiac output. The addition of a simple two-stage LC filter to the front end of the pacemaker enables cardiac output to be maintained during the use of surgical diathermy. (Although this article refers specifically to the Devices E4160 series pacemakers, the filter can, in principle, be used with any external pacemaker.

Diathermy↗