A structural model for human transfer factor.
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Alkaline Phosphatase↗
Biomedical subjects
D H Regan
Publications and source records attributed to D H Regan.
Red cell aging. I. Surface charge density and sialic acid content of density-fractionated human erythrocytes.
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Adult↗
Glutamate oxidation of 6C3HED lymphoma: effects of L-asparaginase on sensitive and resistant lines.
L-Asparaginase (EC 3.5.1.1) inhibited respiration in sensitive, but not resistant, lines of murine lymphoma 6C3HED. Glucose, in these tumor lines, was principally converted to lactate, and very little was oxidized in the citric acid cycle or hexose monophosphate shunt. The cells derived 70-80% of their respiratory CO(2) from glutamine or glutamate. Asparaginase had no effect on the pattern of glucose utilization. The differential effect on oxygen consumption may result from the absence of asparagine synthetase in sensitive cells. Respiration may be inhibited by accumulation of the aspartate, the product of glutamate oxidation. Resistant lymphoma cells remove aspartate by converting it to asparagine. Sensitive cells, which lack asparagine synthetase, cannot make asparagine.
Amino Acids↗
Glutamate-mediated respiration in tumors.
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Animals↗
Defibrination syndrome: changing concepts and recognition of the low grade form.
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Afibrinogenemia↗