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Biomedical subjects

D H Nicholson

Publications and source records attributed to D H Nicholson.

36 records · Page 2Linked to original sources
PubMed1978

Epibulbar Kaposi sarcoma.

This report illustrates the clinical and pathological features of epibulbar Kaposi sarcoma in an adult who had no other cutaneous or systemic manifestations of the disorder.

Aged↗
PubMed1978

Small melanomas of the choroid.

We reviewed 38 cases of small choroidal melanomas on file in the Eye Pathology Laboratory of Bascom Palmer Eye Institute, Miami. Clinical and histopathological features of these cases were noted, and clinical follow-up information was obtained for 36 (95%) of the patients. Two tumor deaths occurred among the 18 patients that had a possible follow-up period of six years of more, yielding a tumor death rate of 11%. Retrospective analysis of clinical records and photographs permitted us to correlate the presence or absence of documented tumor growth with the degree of mitotic activity.

Adolescent↗
PubMed1977

Intraocular extension of squamous cell carcinoma of the conjunctiva.

The present case report illustrates the clinical and pathologic features of intraocular invasion by squamous cell carcinoma of the conjunctiva. Cytologic study of aqueous humor aspirate is a useful technique for confirming the diagnosis of this unusual route of tumor extension.

Aged↗
PubMed1977

A clinical and histopathological study of François-Neetens speckled corneal dystrophy.

A 57-year-old black man had François-Neetens speckled dystrophy of the cornea and orbital phycomycosis. Examination of family members confirmed an auto-somal-dominant pattern of inheritance. Light and electron microscopic study of the cornea of a blind eye disclosed that the corneal opacities were represented by swollen, vacuolated keratocytes filled with histochemically demonstrable acid mucopolysaccharide and complex lipids. Thus, this dystrophy may represent a dominantly inherited metabolic disorder confined to the cornea.

Adolescent↗
PubMed1976

Ocular toxoplasmosis in an adult receiving long-term corticosteroid therapy.

Sudden death of a 58-year-old woman who developed ocular toxoplasmosis while receiving long-term systemic corticosteroid therapy permitted correlation of early histopathologic lesions with their clinical counterpart recorded on fundus photographs. A wide-spread, paravascular, whitish, retinal opacification dominated the initial clinical picture. These lesions were represented histologically by focal zones of inner retinal necrosis located adjacent to arteries and veins. No associated inflammatory cell infiltrate was present, and numerous viable free Toxoplasma organisms were consistently present at the interface between necrotic and healthy retina. Electron microscopy of formaldehyde-fixed tissue provided a useful technique for confirming the identity of the infecting organism in the absence of serologic or culture data.

Adrenal Cortex Hormones↗
PubMed1976

Light and electron microscopic study of early lesions in angiomatosis retinae.

Multiple early untreated lesions of angiomatosis retinae in the peripheral retina and optic disk were discovered after death in both eyes of a patient with von Hippel-Lindau disease. Each of the four peripheral angiomas was studied by a different technique: routine light microscopy of serial histologic sections, electron microscopy, flat mount and trypsin digestion, and frozen section with special stains for lipid. The large capillaries comprising the core of each angioma displayed normal endothelium, basement membrane, and pericytes. Thus, capillary hemangioma of the retina is a more correct histopathologic designation for the von Hippel angioma than terms such as hemangioblastoma or hemangioendothelioma. Interstitial cells separating the vascular channels of the angioma were identified as astrocytes that contain large lipid-filled cacuoles. Serial histologic sections demonstrated that both retinal and choroidal vessels communicate with vascular channels of the juxtapapillary capillary hemangiomas.

Angiomatosis↗
PubMed1976

On-line systolic time intervals during anesthesia in patients with and without heart disease.

Twenty-four patients with severe, 24 with moderate, and 24 without heart disease were selected for measurements of systolic time intervals (STI) and blood pressure before and during anesthesia. In all patients anesthesia was induced with thiopental, 4 mg/kg. After tracheal intubation, 12 patients from each heart-disease class received halothane-N2O-O2 (halothane) and 12 patients from each class morphine-d-tubocurarine-N2O-O2 (MS-dTc). Thiopental increased the pre-ejection period (PEP), decreased left ventricular ejection time (LVET), and accelerated heart rate (HR). These changes were similar in patients with and without heart disease. Halothane and and MS-dTc lowered systolic blood pressure and increased PEP/LVET. With halothane but not with MS-dTc these changes were more pronounced in patients who had heart disease. Changes of the PEP/LVET ratio during halothane anesthesia were a better discriminating variable among patients without, with moderate, and with severe heart disease than were changes in systolic blood pressure.

Adult↗