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Biomedical subjects

D H Nguyen

Publications and source records attributed to D H Nguyen.

62 records · Page 4Linked to original sources
PubMed1984

[Anterothoracic colonic replacement in cicatricial caustic strictures of the esophagus in a 1-stage procedure].

Five cases of oesophageal stricture secondary to caustic ingestion are presented. The colon, as a total bypass graft, was applied in all patients; two with right hemicolon and three with isoperistaltic transverse colon. The colon was placed subcutaneously, with the operation being performed as a one-stage procedure. A good functional result of the colon bypass, could be achieved in all persons.

Accidents, Home↗
PubMed1981

Effects of AR-L 115 BS on arterial and venous muscle tone in vitro.

The effects of the cardiotonic drug 2-[(2-methoxy-4-methyl-sulfinyl)phenyl]-1H-imidazo[4,5-b]pyridine (AR-L 115 BS) on strips from isolated human veins and on strips from bovine veins and arteries were studied. The effects depended on the type and on the site of origin of the vessel. Pre-stretched human saphenous vein strips always relaxed in presence of AR-L 115 BS (greater than 10(-4) mol/l) while jugular vein strips seemed rather unaffected. Pre-stretched bovine facial vein strips always relaxed in presence of AR-L 115 BS, proximal branches being significantly more sensitive to the drug than distal branches. In bovine facial arteries AR-L 115 BS (greater than 10(-4) mol/l) produced either no change or a small increase in tension. When the arteries were pre-contracted by application of 50 mmol/l K+, low concentrations (less than 10(-5) mol/l) increased the tension while high concentrations (greater than 10(-5) mol/l) induced relaxation. The relaxing power of AR-L 115 BS on pre-contracted vein strips seemed better than that of nifedipine and less than that of Na nitroprusside.

Acetylcholine↗
PubMed1981

[Urgent pericardiectomy, 15 cases (author's transl)].

UNLABELLED: 15 cases of pericarditis with tamponade operated as emergency cases in Cho Ray Hospital from November 1976 to January 1979 are dealt with. In these 15 cases, 11 were urgently treated with pericardiectomy, 3 cases with pericardiotomy and one case with repeated pericardial punctures. From these latters pericardiectomy had to be performed in one case later because of constrictive pericarditis and evolutive cardiac failure. ETIOLOGY: Pericardial and metastatic tumour 5, suppurative pericarditis 7, Haemopericard after closed chest trauma 1, rheumatic fever 1, tuberculosis 1. RESULTS: 11 patients showed good results, 3 patients died of disseminated lesions of cancer, 1 patient with suppurative pericarditis died a few days after the operation of respiratory insufficiency. A conservative operation seems to be impossible for radically curing the disease and many post-operative complications may occur.

Adolescent↗
PubMed1980

Effect of potassium on isolated bovine facial and human saphenous veins.

A moderate elevation of external (K0+) (5--10 mM) induces relaxation in bovine facial and human saphenous veins. A further increase of (K0+) leads to biphasic reactions (relaxation followed by contraction). Concentrations of (K0+) higher than about 15 mM cause contractions only. The potassium-induced relaxation may be explained by the stimulation of an electrogenic sodium pump.

Animals↗
PubMedDate not supplied

Tumor necrosis factor-alpha and interleukin-1 induce activation of MAP kinase and SAP kinase in human neuroma fibroblasts.

Two cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1), which are released by macrophages during the early inflammatory phase of nerve injury, are known to induce activation of mitogen-activated protein kinase (MAPK) and stress-activated protein kinase (SAPK), which locate at different signal transduction pathways and are involved in cell cycle G0/G1 transition and cellular proliferation in human fibroblasts. Activation of these two protein kinases by the cytokines may stimulate fibroblast proliferation in damaged nerves and thereby play a role in the formation of a neuroma, a disorganized mass of tissue that interferes with neural regeneration and repair. To investigate the possibility that this mechanism is operative in neuroma formation, we used cultured, serum-starved fibroblasts from surgically removed human neuromas stimulated with TNF-alpha and/or IL-1 alpha and IL-1 beta, and measured the activation of MAPK and SAPK using myelin basic protein (MBP) and human c-Jun (1-169) glutathione S-agarose transferase (GST) fusion protein as substrates. For comparison, neuroma fibroblast cultures were also stimulated with phorbol 12-myristate 13-acetate (PMA) and platelet-derived growth factor-AB (PDGF-AB), a potent activator for MAPK. TNF-alpha and both forms of IL-1 produced a rapid activation of MAPK, with a peak at 15 min for TNF-alpha stimulation, and a peak at 30 min for IL-1 stimulation. TNF-alpha combined with either IL-1 alpha or IL-1 beta produced a synergistic effect on the activation of MAPK. The increases in MAPK induced by TNF-alpha and IL-1 were similar to the increases induced by PMA and PDGF-AB. To confirm the presence of MAPK, immunoprecipitation and immunoblotting were carried out on experimental and control lysates. TNF-alpha and IL-1 also increased activation of SAPK, but to a lesser extent than MAPK. PMA and PDGF-AB were also much less effective in stimulating activation of SAPK. Our findings indicate that TNF-alpha and IL-1 activate parallel signal transduction pathways in human neuroma fibroblasts, and that they are relatively stronger activators of MAPK than of SAPK. Previous studies have convincingly demonstrated that MAPK and SAPK are involved in human fibroblast proliferation. The results of our study suggest that TNF-alpha and IL-1 may play a role in frustrating functional nerve regeneration after injury by stimulating these two kinases, which, in turn, leads to fibroblast proliferation and formation of neuromas.

Calcium-Calmodulin-Dependent Protein Kinases↗