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Biomedical subjects

D H Nelson

Publications and source records attributed to D H Nelson.

65 records · Page 4Linked to original sources
PubMedDate not supplied

Dexamethasone and sphingolipids inhibit concanavalin A stimulated glucose uptake in 3T3-L1 fibroblasts.

Studies were carried out in 3T3-L1 fibroblasts to determine the effect of sphingolipids and corticosteroids on concanavalin A stimulated glucose uptake. Sphinganine (40 microM) and sphingosine (40 AND 100 microM) significantly inhibited concanavalin A stimulated glucose uptake (P less than 0.025 & less than 0.005). Prior incubation with 10(-7) M dexamethasone also significantly inhibited concanavalin A stimulated glucose uptake (P less than 0.005). The known effects of corticosteroids on sphingolipid synthesis, degradation, and tissue levels, suggest inhibition by corticosteroids of glucose uptake may be through effects of the steroid on sphingolipid metabolism.

Animals↗
PubMedDate not supplied

Saccular aneurysm of infancy and early childhood.

A case of intracranial saccular aneurysm occurring in early childhood and presenting with sudden dysphasia and hemiplegia is reported. A review of the literature emphasizes the rarity of this lesion. Despite a significant preoperative neurological deficit, the patient tolerated aneurysm clipping and recovered well. The majority of reported cases involve males under 2 years old. Aneurysms in infants have a distribution different from that seen in adults. Microscopic examination of these lesions fails to show any evidence of inflammation or atherosclerosis. The data suggest that the pathogenesis of these rare childhool lesions differs from that of adult saccular aneurysms.

Cerebral Angiography↗