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Biomedical subjects

D H Melcher

Publications and source records attributed to D H Melcher.

At least 37 records · Page 2Linked to original sources

The place of cytology in laryngeal diagnosis.

A cytological procedure providing useful supplementary information in the diagnosis of laryngeal malignancy is described. Of 51 patients, 22 had complete correlation with histological examination in confirming a benign condition. Twenty patients had complete correlation in confirming a malignant lesion. Five patients showed cellular atypia in the presence of benign conditions. Three showed atypia, of which 2 were malignant, 1 being unstable histologically but with no evidence of frank malignancy. Ten patients had been irradiated previously; in all cases the distinction between residual disease and no evident disease was correctly diagnosed with respect to the histological appearance.

Carcinoma in Situ↗

Dilatation of the parous non-pregnant cervix.

In vitro cervical dilatations were carried out on 33 uteri removed by hysterectomy for conditions not involving the cervix from parous women in their reproductive span of life. A specially designed force measuring dilator was used for all the tests. The analysis of the results involved the application of a thick-walled cylindrical stress determination technique. Using this approach it was possible to calculate quasi-elastic moduli for different degrees of dilatation and obtain theoretical distributions of radial and circumferential stress across the cervical wall. These results indicated a yielding of the cervical tissue at about 9 to 11 mm. dilatation in a significant number of cases.

Cervix Uteri↗

Lipogranuloma of bone.

Five cases of lipogranuloma of bone are described. The possible aetiology and nomenclature of the condition are discussed.

Bone Diseases↗

Rapid outpatient detection of rectal cancer by gloved digital scrape cytology.

Prior to a surgical operation for carcinoma of the rectum, it is necessary to have a tissue diagnosis. In a study undertaken to correlate rectal cytology with histopathology and to assess its accuracy, 78 patients had cytology performed at their initial rectal examination in the outpatient department. The results showed no false-positive and three false-negative cytologic diagnoses. A positive cytology report is thus indicative of carcinoma, but a negative report does not exclude it. The method is inexpensive, quick, painless and without complication.

Adenocarcinoma↗