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Biomedical subjects

D H Marjot

Publications and source records attributed to D H Marjot.

At least 19 recordsLinked to original sources
PubMed1990

Ethnic differences in the consequences of alcohol misuse.

The drinking habits of Asian and indigenous patients receiving in-patient care for alcoholism in West London were studied. Although both racial groups reported similar levels of current alcohol intake, the Asian developed problems and presented for in-patient detoxification with a shorter mean duration of drinking than the indigenous subjects. Values for mean corpuscular volume (MCV) and gamma glutamyl transpeptidase (GGT) were higher in the Asians, suggesting the Asians were at greater risk of alcohol-related physical damage.

Adult↗
PubMed1989

Alcohol-related admissions to a psychiatric hospital: a comparison of Asians and Europeans.

The prevalence of alcohol-related problems in the British Asian community is unknown. We obtained details of all patients living in Southall who had been admitted with a primary alcohol-related diagnosis to a psychiatric hospital from 1980 to 1987. We used 1981 census data to calculate overall and age-specific incidence rates for Asian and European men and woman, expressed per 10,000 subjects over the 7-year period. The overall incidence in Asian men (105.8) was markedly higher than in European men (54.3) (p less than 0.001). The overall incidence in Asian women was markedly lower than in European women (4.1 versus 18.6, p less than 0.001). Proportionately more Asian than European men were married (82% versus 34%, p less than 0.001). This pilot study suggests that alcohol-related problems severe enough to warrant inpatient treatment are unduly common in Southall Asian men, especially in married subjects. Further community-based studies are needed to ascertain the prevalence of alcoholism in this and other British Asian communities.

Adolescent↗
PubMed1989

Correlations between serum proteins modified by acetaldehyde and biochemical variables in heavy drinkers.

A strong and highly significant correlation was observed between serum aspartate transaminase (AST) activity and an index of the cytotoxic activity associated with serum proteins modified by acetaldehyde in a group of 24 heavy drinkers. A weaker but significant correlation (R = 0.564, p = 0.008) was found between total serum creatine kinase activity and this index of serum cytotoxicity. As it is likely that the concentration of circulating modified protein was largely determined by the quantity of free acetaldehyde generated in the liver and that the AST activity was mainly derived from damaged hepatocytes, the data indicate a correlation between hepatic acetaldehyde generation and hepatocyte damage. This correlation may indicate either that increased quantities of acetaldehyde are released by damaged hepatocytes or that acetaldehyde is hepatotoxic in vivo. As only the creatine kinase isoenzyme present in skeletal muscle (CK-MM) was demonstrable in the serum in all but one of our patients, the data also suggest that circulating modified serum proteins may be toxic towards skeletal muscle cells.

Acetaldehyde↗
PubMed1985

Increased free-radical activity in alcoholics.

The identification of the main dieneconjugated "free-radical marker" in human serum led to a study of free-radical activity in chronic alcoholics. 66 patients were investigated immediately after alcohol withdrawal and over 1-4 weeks' follow-up. The control groups were 76 normal subjects, 78 patients with liver disease, 30 patients on long-term antiepileptic drug treatment, 9 pregnant women, and 99 unselected hospital patients. 82% of chronic alcoholics had a significantly higher than normal level of phospholipid-esterified 9,11 linoleicacid isomer in blood collected within 24 h of their last alcoholic drink. The levels fell to normal over the next 2-4 days but continued to decline within the normal range for 2-3 weeks. There was no rise in the level of the isomer in normal controls after an acute alcohol load. The results suggest that chronic alcoholism may induce a specific detoxifying mechanism which is activated by alcohol and which entails or depends on greatly increased free-radical activity.

Adolescent↗
PubMed1979

Detection of alcoholic cardiomyopathy by serum enzyme and isoenzyme determination.

Serum creatine kinase and lactate dehydrogenase isoenzymes were studied in 73 patients with alcoholism, including two patients with clinical alcoholic cardiomyopathy and 28 patients with haemodynamic evidence (systolic time interval abnormality) of disordered myocardial function. No isoenzyme abnormalities suggestive of myocardial injury were observed. We conclude that isoenzyme examination is unsuitable for the early detection of myocardial damage from alcohol.

Adult↗
PubMed1978

Hazards of diconal.

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Analgesics, Opioid↗
PubMed1972

Problem drinking.

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Alcohol Drinking↗