Search PubMed⌕ Search

Biomedical subjects

D H Lu

Publications and source records attributed to D H Lu.

22 records · Page 2Linked to original sources
PubMed1992

[Immunohistochemical research for T cell subsets infiltrating in squamous cell carcinoma of oral cavity by monoclonal antibody].

Specimens from 25 patients with squamous cell carcinoma of the oral cavity were examined immunohistochemically, using Streptavidin-Biotin-Peroxidase Complex (ABC) with a series of monoclonal antibodies. Subsets of the infiltrating T lymphocytes in cancer tissues were identified and analysed. We found that, T cell infiltration was predominant. The degree of T cell infiltration was correlated well to the differentiation of cancer and a significant difference existed in OKT 3 + count between the better and the poorer differentiated tumors. Comparing with OKT4+, OKT8+ cells were predominant around cancer nest, the ratio is 1:2. Our results suggest that T cell subsets play a key role in immune response to tumor. Variable quantities and ratio of T subset might be associated with immune regulation imbalance, and reflected malignant grade of cancer and prognosis of the patients.

Adult↗
PubMed1988

[Pathological analysis of 1458 cases of tumor in the sella turcica region].

The sella turcica region is an anatomical site preferential for various types of intracranial tumors. Pathological analysis of 1458 cases of tumor in this region is presented. They comprised 20.16% of the intracranial tumors. Among them, 846(59.1%) were pituitary adenomas, 433(29.7%) craniopharyngiomas, 91(6.2%) meningiomas and 42(2.9%) germinomas. In pituitary adenomas, chromophobe adenoma was predominant, mixed cell adenoma next and no basophilic adenoma was observed. Of craniopharyngiomas they were divided into cystic, partly solid and cystic, and calcified types grossly and histologically into adamantinomatous, squamous and calcified types. In this kind of tumor, well differentiated cells were consistent to the clinical benign course. For meningiomas, histologically meningotheliomatous type was most common in this region. In previous reports, germinomas in the sella turcica region were so-called ectopic pinealoma. Now it is well known that this tumor arises from germ cells, hence, the synonym "ectopic pinealoma" is obsolete. The germinomas in the sella turcica region accounted for 44.68% of all intracranial germinomas. Microscopic picture of this tumor was similar to those of seminoma of the testicle and dysgerminoma of the ovary. Although gliomas, teratomas, giant cell tumors and chondromas were uncommon in the sella turcica region, the authors believe that they should be considered in the differential diagnosis of tumors in the sella turcica region.

Adenoma↗