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Biomedical subjects

D H King

Publications and source records attributed to D H King.

At least 19 recordsLinked to original sources

The treatment of major devascularizing injuries of the upper extremity.

The most complex aspect of managing major devascularizing injuries is decision making. The decision to amputate or revascularize is not difficult in injuries that have extremely favorable or unfavorable outcomes. In less obvious cases, however, decision making can be extremely complex, and many factors influence the surgeon's decision. In borderline cases, the optimal decision may never become clear, even in hindsight, much less at the time of the initial surgery. Nor are the ramifications of these decisions trivial. The decision whether to attempt revascularization or perform a revision amputation can have a profound influence on the course of a patient's life. Despite the critical nature of these decisions, there are few firm data to guide the decision-making process in complex cases. In addition, there are a virtually infinite number of possible injury presentations, and each factor to be considered has shades and gradations of its own. Ultimately, the decision comes down to the surgeon's knowledge, experience, and ability to project the expected risk-benefit ratios of the various options and, at the same time, attempt to account for all the factors that may influence outcome. Where more than one reasonable option exists, the patient's or family's wishes can be a critical factor as well.

Amputation, Surgical↗

A statistical analysis of the accuracy of sonography of the patellar tendon.

The purpose of this study was to evaluate the accuracy of sonography in measuring the dimensions of the cadaveric patellar tendon to determine whether sonography might have future applications in the preoperative assessment of autograft tissues before anterior cruciate ligament (ACL) reconstruction. Eleven lower-extremity human cadaveric limbs, with an average donor age of 75 years (range, 67 to 87 years), underwent patellar sonography with a 7.5-MHz transducer. Patellar tendon thickness, width, and length were measured sonographically. After skin removal, the patellar tendon dimensions were measured manually. Sonographic and manual measurements were compared statistically. Sonographic and manual measurements showed good agreement for thickness. There was poor agreement for width and length. Because of its limited accuracy, sonography cannot be recommended for the measurement of the patellar tendon before ACL reconstruction.

Aged↗

Amyopathic dermatomyositis associated with transitional cell carcinoma of the bladder.

Transitional cell carcinoma of the bladder is the most common tumor of the urinary tract. However, it has only been reported twice in the literature to be associated with the paraneoplastic syndrome dermatomyositis. We report a case of amyopathic dermatomyositis in a patient whose painless gross hematuria was due to transitional cell carcinoma of the bladder as well as review this association.

Aged↗

Valve repair for aortic insufficiency: surgical classification and techniques.

OBJECTIVE: Valve repair for aortic insufficiency may provide an alternative to aortic valve replacement in selected patients. This repair could be an attempt at permanent correction or palliation to allow the aortic annulus to grow and avoid the use of anticoagulation. Based upon a five-year experience, we proposed a classification according to valvular anatomy which could be a guide to patient and procedure selection. METHODS: Between September 1989 and February 1995, 44 consecutive patients underwent aortic valvuloplasty for aortic incompetence at our institution. Patients' ages ranged from 19 months to 76 years with a mean of 33 years. The etiology of aortic incompetence was congenital in 30 patients, degenerative in 7 patients, rheumatic in 5 patients, and infective endocarditis in 2. Aortic valve lesions were classified into three different types: type I, aortic annular dilation (8 patients); type II, excessive aortic leaflet tissue (12 patients); and type III, restricted leaflet motion with or without deficient leaflet tissue (24 patients). Type I needed commissural plication in 7 patients; and aortic annuloplasty, which was simple in 6 patients, and pericardial-augmented in 2. Type II necessitated midleaflet excision in 11 patients and leaflet plication in 7. Type III required leaflet extension in 19 patients, leaflet replacement in 1 patient, aortic valve commissurotomy in 13 patients augmentation commissurorrhaphy in 2, leaflet shaving in 4, and repair of leaflet perforation in 2. RESULTS: Postoperative echocardiography revealed a significant decrease in the degree of aortic incompetence. Mean follow-up was 2.6 +/- 1.4 years. There was no mortality. Patients improved as is evident by NYHA functional class postoperatively. Eight of the first 13 patients (18%) needed reoperation. Three of these reoperations were bail-out procedures, and 3 patients (7%) who underwent the leaflet extension technique were reoperated upon 19 months to 3 years later. Presently, 23 patients are without anticoagulation, 11 take aspirin and 2 receive coumadin for combined mitral procedures. CONCLUSIONS: Aortic valve repair provides a low risk option with satisfactory intermediate-term results for the treatment of aortic insufficiency in appropriately selected patients. Patient and procedure selection may be based upon the echocardiographic anatomy of the aortic valve, and a comparative risk benefit appraisal with valve replacement.

Adolescent↗

Mucinous adenocarcinoma arising from a suprapubic cystostomy site without bladder involvement.

Carcinoma arising from a suprapubic cystostomy site in patients with spinal cord injury has been infrequently described. In all previously reported cases, they have been squamous cell carcinomas. Our patient is a 68 year old male with T10 complete thoracic paraplegia who presented with an exophytic mass extending from his suprapubic cystostomy tract. Biopsy revealed mucinous adenocarcinoma. Carcinoma of the suprapubic cystostomy tract should be considered in those patients who present with bloody drainage and/or masses arising from the suprapubic cystostomy site.

Adenocarcinoma, Mucinous↗

Holmium: YAG laser damage to ureteral guidewire.

The holmium:yttrium-aluminum-garnet (holmium:YAG) laser effectively fragments urinary calculi of all compositions. Complications have been minimal and mostly attributable to the ureteroscopy as opposed to the laser. We report a case in which the polytetrafluoroethylene (PTFE) coating of a ureteral guidewire was broken with the holmium:YAG laser and remained in the collecting system after the guidewire was removed postoperatively. The patient required cystoscopy to remove the guidewire coating.

Adult↗

A one-stop vascular clinic: a practical proposition with non-invasive assessment.

One-stop clinics are becoming increasingly popular with both patients and their general practitioners. Traditionally, vascular patients have needed to attend hospital two or three times for clinical examination and investigations. We have introduced a one-stop clinic for patients with lower limb arterial disease (LLAD) and aortic aneurysms. In 92 clinics over 2 years, 1194 new patients and 1409 follow-up patients were seen, with LLAD being the largest single category comprising 40% of the patients seen, followed by varicose veins (25%), carotid disease (12%), and aortic aneurysms (8%). Overall, 57% of patients had non-invasive imaging performed, either in the clinic or on a separate visit. Performing all LLAD and aortic scans in the clinic requires 1.9 h of imaging time per clinic. Extending in-clinic scanning to patients with varicose veins and carotid disease would increase this to 3.9 h of scanning per clinic and require a duplex scanner and an additional technologist in the clinic.

Aortic Aneurysm↗

Additional experience with continent urinary diversion using cutaneous ileocecocystoplasty.

OBJECTIVES: We have used the technique of ileocecocystoplasty with a cutaneous continent catheterizable limb to incorporate native bladder into the urinary reservoir to treat patients with functional and anatomic bladder disorders. This review was performed to evaluate the outcome of the first 8 patients who underwent this procedure. METHODS: A retrospective analysis was performed by chart review and telephone interview. Patients' preoperative and postoperative bladder status and management, satisfaction rating, and renal function are reported. RESULTS: Follow-up of 9 to 64 months (mean, 33.9) in our first 8 patients reveals excellent results in all, including 1 patient who prefers an indwelling catheter due to progressive neuromuscular disability. CONCLUSIONS: Cutaneous ileocecocystoplasty offers urologists and patients continent urinary diversion with minimal morbidity and is a much less extensive procedure than complete bladder replacement.

Adult↗

Non-invasive assessment of arterial disease: a comparison of Quickscan with intra-arterial digital subtraction angiography.

The ability of Quickscan to identify haemodynamically significant lesions in the arteries of the lower limb was studied. Quickscan was prospectively compared with intra-arterial digital subtraction angiography (IADSA) of the iliac, femoral and popliteal arteries. In 155 patients, 631 arterial segments were evaluated. A Quickscan frequency ratio of 1:3 or greater had a sensitivity of 93 per cent and a specificity of 85 per cent in detecting a stenosis of more than 50 per cent diameter reduction (67 per cent area reduction) in the iliac artery, as shown on IADSA. The sensitivity and specificity in the femoral artery were 85 and 96 per cent respectively, and in the popliteal artery 82 and 98 per cent respectively. In the detection of occlusion, Quickscan had a sensitivity and specificity of 84 and 98 per cent respectively in the iliac artery, 94 and 97 per cent respectively in the femoral artery, and 94 and 85 per cent respectively in the popliteal artery. Quickscan is an inexpensive, quick and non-invasive method of screening for peripheral vascular disease in the lower limb.

Adult↗

Anterior pulmonary translocation for repair of truncus arteriosus with interrupted arch.

A newborn was found to have truncus arteriosus and an interrupted aortic arch, and underwent primary repair. The patient did well initially, but, by 8 weeks postoperatively, showed evidence of severe compression of the right pulmonary artery. At reoperation, the pulmonary artery was found to be compressed by a large aortic root (truncal root) and the retroaortic area was narrowed. The pulmonary artery bifurcation was therefore translocated anteriorly to alleviate the compression.

Aorta, Thoracic↗

Strategies for repair of congenital heart defects in infants without the use of blood.

Eleven infants and children with a body weight of less than 10 kg (median weight, 6.8 kg) whose parents were Jehovah's Witnesses underwent repair (n = 10) or palliation (n = 1) of congenital heart defects without the use of blood products and with (n = 9) or without (n = 2) cardiopulmonary bypass (CPB). In 1 neonate (weight, 3.2 kg) with critical aortic stenosis, moderate hypothermia and a 3.5-minute period of inflow occlusion and circulatory arrest allowed an aortic valvotomy; in another patient (weight, 7.0 kg) with tricuspid and pulmonary atresia, transposition of the great arteries, and persistent left superior vena cava, a bilateral bidirectional cavopulmonary shunt procedure was performed without CPB. Use of heparin-bonded tubing allowed reduction of the initial dose of heparin sodium to 1 mg/kg. Tissue perfusion and oxygenation on bypass were adequate, as evidenced by a mean lowest pH of 7.38 +/- 0.09 and a mean lowest venous oxygen tension of 65.0 +/- 36.2 mm Hg. Although the mean postoperative hematocrit (Hct) was lower than the mean preoperative Hct (p < 0.05, analysis of variance and Scheffe's F test), the Hct within 2 hours after CPB was restored to a value (mean Hct, 27.5% +/- 1.0%) between the preoperative Hct (mean value, 42.7% +/- 3.5%) and the lowest Hct on CPB (mean value, 18.4% +/- 1.4%). The Hct at discharge was 31.8% +/- 1.1%. The median postoperative blood loss was 9 mL/kg. There was no perioperative mortality. The median stay in the intensive care unit and the hospital was 2 days and 6 days, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Blood Loss, Surgical↗

Renal cell carcinoma metastatic to the gallbladder or prostate: two case reports.

Although metastatic renal cell carcinoma (RCC) is not uncommon, dissemination to the gallbladder or prostate is very rare. We present 1 case of RCC with synchronous metastasis to the gallbladder and 1 case of RCC with metachronous metastasis to the prostate. These cases illustrate the propensity of RCC for unpredictable presentation and unusual sites of metastases. The first case also illustrates the benefit of adjuvant nephrectomy with excision of a solitary metastasis. Patterns of RCC metastases and flow cytometric analysis of RCC are discussed.

Aged↗

Impedance analysis compared with Quickscan in the detection of graft-related stenoses.

OBJECTIVE: To compare two methods of detecting graft stenoses after infrainguinal bypass. DESIGN: Prospective study. SETTING: Vascular Laboratory, University Hospital. MATERIALS: 110 infrainguinal graft studies (60 vein, 50 PTFE) in 74 patients were performed prospectively to detect graft-related stenoses. CHIEF OUTCOME MEASURES: The diagnostic accuracy of computer assisted impedance analysis was assessed using Quickscan (QS) as the gold standard in the detection of graft-related stenoses. CHIEF RESULTS: QS showed occlusion in 4 grafts (two vein and two PTFE), no stenosis in 86 graft studies and stenoses in 20 studies. All 12 stenoses with a frequency ratio > or = 1.4, were confirmed with intraarterial digital subtraction angiography (IADSA). Eight stenoses with a frequency ratio of 1:3 continued graft surveillance. The median thigh impedance score of vein grafts with QS confirmed stenoses was 0.51 (0.36-0.70) compared with 0.44 (0.30-0.60) for non-stenosed vein grafts (p = 0.015, Mann-Whitney U test). The median thigh impedance score in PTFE graft with QS confirmed stenosis was 0.58 (0.53-0.76) compared with 0.42 (0.28-0.73 for non-stenosed grafts (p = 0.0001). An impedance score > 0.45 has been suggested for detection of "at risk" grafts. Using QS as the gold standard, impedance assessment gave 90% sensitivity, 63% specificity in the thigh; 80%, 52% in the calf and 90%, 46% taking the higher score on calf for thigh data. Taking a QS frequency ratio of 1:4 as indicating a significant stenosis (50% diameter reduction), 11% (12/106) of surveillance studies went on to intervention, that is 12/74 (16%) grafts. CONCLUSIONS: If the higher impedance score derived from either the calf or thigh was used to detect stenoses, 60% (64/106) of graft studies would have been referred for intervention. We believe this high level of intervention is unrealistic and cannot therefore recommend impedance analysis for graft surveillance.

Angiography, Digital Subtraction↗

[Ultrasonic angiography in diagnosis of peripheral vascular disease].

The ability of Quickscan (QS) was studied to assess haemodynamically significant lesions in the iliac and femoro-popliteal arteries. Quickscan was prospectively and independently compared to digital subtraction angiography (DSA) of the iliac and femoro-poplited arteries. In 155 patients, 631 arterial segments were evaluated. A QS frequency ratio of greater than 1:3 had a sensitivity of 93% and a specificity of 85% in detecting stenosis > 50% diameter (75% area) reduction in the iliac artery as shown on DSA. The sensitivity and specificity for stenosis in the femoral and popliteal arteries were 85%, 96%, 82%, 98% respectively. In the detection of occlusion, QS had a sensitivity of 84% and a specifity of 98% in the iliac artery; 94%, 97%, in the femoral; and 94%, 85% in the popliteal arteries respectively. There was a significant correlation between the area reduction found by QS and the calf/brachial pressure index (CBI) (r = -0.77 P < 0.01). 35 patients underwent successfully angioplasty based on QS findings. We conclude that quickscan can provide an inexpensive, quick and noninvasive screening technique for the routine initial assessment of peripheral vascular disease.

Aged↗