Biomedical subjects
Publications and source records attributed to D H Dail.
Two cases of fibrohistiocytic tumours of the lung are presented and histogenesis of this group of this group of tumours is discussed. An essentially biphasic pattern of histiocytes and fibroblasts, and the presence of myofibroblasts and undifferentiated mesenchymal cells is similar to the fibro histiocytic neoplasms in other locations.
Nineteen papillary, non-invasive tumors arising from the bronchial epithelium but excluding carcinoid tumors are reviewed. Eight were solitary papillomas of which three were covered with a mixture of epithelial types. Seven were benign but one had a focus of carcinoma in situ. A similar change was seen in bronchial epithelium adjacent to a papilloma. Two cases of recurrent papillomas were seen and in one, carcinomatous changes eventually occurred. Two combined benign brochial cystadenomas with papillomas are described. One transitional celled papillary carcinoma in situ and five other papillary carcinomas in situ are described. One bronchial papilloma covered with dysplastic epithelium was considered an intermediate stage in the development of carcinoma in situ. Two papillary tumors may have arisen from peripheral bronchi or brochioles. Their lining cells resembled Clara cells, they grew by local expansion, and there was an absence of malignant features. The differential characteristics of two secondary carcinomatous polypoidal tumors are described.
A bacterium with growth characteristics similar to, but genetically distinct from, either Legionella pneumophila or WIGA (a "rickettsia-like agent") was obtained from a postmortem lung specimen of a patient with fatal atypical pneumonia at the M. D. Anderson Hospital and Tumor Institute in Houston, Texas. This bacterium and WIGA have essentially the same cellular fatty acid composition, which is distinct from that of L. pneumophila. Deoxyribonucleic acid-reletadness studies show that the isolate from Texas is only about 10% related to both L. pneumophila and WIGA and there fore may represent a new species. This new bacterium should be considered in selecting laboratory procedures in the diagnosis of atypical pneumonia.
A patient with subacute bacterial endocarditis, who had a prosthetic mitral valve, exhibited hypocomplementemia, mixed (IgG, IgM) cryoglobulinemia, and widespread dermal vasculitis with IgM deposited at the dermoepidermal junction. Postmortem findings included immune-complex glomerulonephritis and deposits of IgG in the choroid plexus. These findings are consistent with a generalized vasculitis, which may be mediated by circulating immune complexes; basement membrane localization of immune complexes to the skin and choroid plexus appears not to be specific for systemic lupus erythematosus, as has been previously thought, but may represent the general phenomenon of immune-mediated pathogenesis.
Explore the source record for details and available documents.
A patient found to have the unusual condition of bile duct adenomatosis of the liver is discussed. The liver was "peppered" with small subcapsular nodules, which microscopically appeared as multilocular cysts, lined with cuboidal cells similar to those of normal bile ducts. This benign condition most likely is developmental in etiology, and may present early in life as polycystic liver disease, or later when discovered as an incidental finding at laparotomy or autopsy. Its differentiation from metastatic disease by the surgeon on gross examination of liver alone may not be possible.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Patients with solid tumor malignancies who failed extensive front-line treatments were treated with high-dose BCNU followed by autologous bone marrow transplantation. Since 1976, 14 patients were treated in this program with BCNU doses ranging from 600 to 1500 mg/m2 over 2 days. Three patients developed pulmonary toxicity only a few weeks after receiving high-dose BCNU at total doses of 900, 1000, and 1500 mg/m2. Two of the three patients had had prior irradiation to the primary tumor. The third patient did not have prior irradiation to the chest but had received prior nitrosourea therapy. The use of high-dose BCNU in transplantation may be limited to early pulmonary toxicity.
Explore the source record for details and available documents.