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Biomedical subjects

D H Baker

Publications and source records attributed to D H Baker.

At least 271 records · Page 15Linked to original sources
PubMed1978

The epidermolytic toxin of Staphylococcus aureus: its failure to bind to cells and its detection in blister fluids of patients with bullous impetigo.

Radioiodinated staphylococcal epidermolytic toxin was found not to bind to erythrocytes, blood leukocytes, trypsin-dispersed keratinocytes, epidermis or whole skin. Moreover the toxin could not be found to bind to murine epithelia by indirect immunofluorescence methods. However, the toxin, measured by radioimmunoassay, could be eluted from the skin of mice undergoing epidermolysis following intraperitoneal injection of toxinogenic Staphylococcus aureus. Furthermore, epidemolysin was measured in the blister fluid of 3 of 5 children with bullous impetigo but not in blister fluid from control patients with other blistering eruptions. Thus epidermolysin has been demonstrated to be present in lesions of the staphylococcal epidermolytic toxin syndrome but its mechanism of action does not involve binding to cells.

Animals↗
PubMed1978

Wilms' tumor to the heart: clinical and radiographic evaluation.

The clinical and radiographic appearances of four children with cardiac extension of Wilms' tumor and four cases from the literature are described. Four of the eight children were seen for "cardiac problems" and four for "routine" Wilms' tumor. In those "routine" cases, there were no clinical suggestions of inferior vena cava or cardiac extension. Preoperative screening for tumor extension may be crucial. However, because of the rarity of cardiac extension, it would be appropriate to screen patients by noninvasive methods such as gray scale ultrasound of the abdomen, echocardiography, or computed tomography before any invasive procedure is considered.

Abdominal Neoplasms↗
PubMed1978

D-cystine utilization by the chick.

Young chicks were fed graded levels of either L-cystine or DL-cystine in a purified crystalline amino acid diet made adequate in methionine but void in cystine. Gain performance and slope-ratio efficacy comparisons indicated that the D-isomer of cystine could not be utilized by the chick.

Animals↗
PubMed1977

Anorexia nervosa - the paucity of radiologic findings in more than fifty patients.

Anorexia nervosa is a self-imposed progressive starvation based on a psychiatric disorder. More than fifty patients (mainly adolescent girls) have had extensive radiologic evaluation. The radiographic findings are an absence of subcutaneous fat, with reduced muscle mass; the gastrointestinal findings are limited to moderate non-obstructive dilatation of small bowel loops with minimal effect on transit. These findings reflect the cachexia and in no way are diagnostic of anorexia nervosa per se.

Adolescent↗
PubMed1977

Nitrogen metabolism, tissue carnosine concentration and blood chemistry of gravid swine fed graded levels of histidine.

Three nitrogen metabolism experiments were conducted to determine the qualitative and quantitative histidine need of first-litter gilts during the last third of pregnancy. A completely purified, crystalline 8amino acid diet was formulated to meet all nutrient needs of the gravid gilt when 2 kg/day was fed. Experiments 1 and 2 were 9-day nitrogen balance studies, each consisting of three littermate gilts subjected to three levels of dietary L-histidine in a Latin square arrangement of treatments. Nitrogen retention was depresed, but not significantly, when less than 0.12% histidine was fed. Complete deletion of histidine, however, did not depress retention below that observed when 0.06% was fed. This suggested that either histidine biosynthesis or its release from endogenous reserves was confounding retention data. Therefore in a third experiment, two gilts were fed a histidine-free diet for 24 days in an attempt to deplete endogenous reserves. For comparison, two siblings were fed 0.12% histidine during this same period. Nitrogen retention tended to be lower for gilts fed the histidine-free diet during each of three consecutive collection periods. Blood hemoglobin, muscle and olfactory bulb carnosine concentration, plasma protein and glutamic-oxaloacetic transaminase activity, and blood urea nitrogen were all unaffected by treatment. Offspring from gilts fed the histidine-free diet had lower blood hemoglobin concentrations than their counterparts from gilts receiving histidine. A tentative recommendation of 0.12% dietary L-histidine would seem justified for gravid swine.

Animals↗
PubMed1977

Nutritional implications of the Maillard reaction: the availability of fructose-phenylalanine to the chick.

Fructose-phenylalanine, the Amadori compound resulting when glucose reacts with phenylalanine, was administered to chicks receiving a phenylalanine-deficient crystalline amino acid diet. The chicks did not respond to oral administration of this molecule which indicated it was nutritionally unavailable as a source of phenylalanine. In vitro protein synthesis studies on liver tissue showed that the rate of incorporation of 14C-phenylalanine into liver solids/mg tissue was significantly lower in chicks fed 0.404%-fructose-phenylalanine than in those not fed this compound. However, when fructose-phenylalanine was added directly to the incubation medium, no reduction of amino acid incorporation occurred. The discrepancy between in vitro and vivo results suggests, therefore, that fructose-phenylalanine is metabolized to another molecule which is causative in reducing liver protein synthesis.

Animals↗
PubMed1977

Neonatal small left colon syndrome: its relationship to aganglionosis and meconium plug syndrome.

Neonatal small left colon syndrome is a cause of functional colon obstruction in newborn infants, with a high association of maternal diabetes. There has been much confusion regarding its relationship to meconium plug syndrome and aganglionosis. Six cases of aganglionosis (2 in infants of diabetic mothers) were encountered in which the radiographic findings were identical to small left colon syndrome, indicating the need for caution in dismissing aganglionosis solely on the basis of a small left colon seen radiographically in a newborn infant with colon obstruction. Small left colon and meconium plug syndrome are overlapping entities in the total spectrum of functional intestinal obstruction in newborn infants.

Adolescent↗
PubMed1977

Diagnosis oligohydramnios-related pulmonary hypoplasia (Potter syndrome): value of portable voiding cystourethrography in newborns with respiratory distress.

Potter renal nonfunctional syndrome is an association of facial and limb anomalies, pulmonary hypoplasia, and fetal renal anomalies which lead to marked oligohydramnios, including renal agenesis (true Potter syndrome), renal cystic dysplasia, and obstructive uropathies. Some infants survive long enough to develop severe respiratory distress secondary to pulmonary hypoplasia. The underlying renal disease is often noted only at autopsy. We studied four infants, only one of whom had clinical signs of the renal nonfunction syndrome. Portable voiding cystourethrography revealed a tiny bladder in three infants with cystic dysplasia kidneys (two of these infants had reflux into unused ureters). Bladder hypertrophy and vesicoureteral reflux secondary to posterior uretral valves were noted in the fourth infant.

Abnormalities, Multiple↗
PubMed1977

Slipped femoral capital epiphysis as a sequela to childhood irradiation for malignant tumors.

Five cases of slipped femoral capital epiphysis were noted in children with prior irradiation for malignancy whose femoral head and neck had been included in the radiation portal. Three of the 5 were patients who had lymphoma. As a result of increasing survival rates for these types of patients, this previously unrecognized radiation-related growth disturbance may be more likely to be seen in the future.

Child↗
PubMed1977

Left adrenal neuroblastoma with normal-appearing urogram.

Adrenal neuroblastomas are usually diagnosed by intravenous urography because of the displacement of the kidney or distortion of its contour. This report describes five children with left adrenal neuroblastoma where the mass was purely anterior to the kidney and produced displacement vectors similar to tumors in the body or tail of the pancreas.

Adrenal Gland Neoplasms↗