Biomedical subjects
Publications and source records attributed to D H Adams.
It is suggested that the Carp (multiple-sclerosis associated and scrapie associated) agents may be the V-R.N.A. form of slow (D.N.A.) viruses which are the aetiological agents of the two diseases.
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The relationship between the major and minor protein components of the myelin sheath, and between fractions soluble and insoluble in chloroform methanol has been studied in rat brain between 5 and 60 days of age. The results suggest a continuous sequential buildup of the myelin sheath, in which while the minor protein components form the major proportion of early myelin their contribution is progressively reduced by the addition of myelin specific proteins. Chloroform methanol insoluble myelin is recognisable before the CMS fraction appears. The minor proteins are present in the brain several days before myelination and then appear to migrate into myelin. However, the myelin specific proteins can only be detected shortly before myelination. The results underline previous suggestions that the myelin sheath has a unique protein composition, and suggest that the specific components arise de novo just before they are required. They are not consistent with the supposition that myelin consists of glial cell membrane and are discussed in relation to current views on the myelination process.
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1. After incorporation of [(14)C]valine in vitro, cerebral microsomes were separated into membrane-bound and free ribosomes by sucrose-density-gradient centrifugation. 2. In preparations from both 4-day-old and adult rats, free and bound ribosomes incorporated [(14)C]valine. Free ribosomes could be found as polysomes, which were highly active. 3. Microsomes labelled with [(14)C]valine in vitro were fractionated after deoxycholate treatment into a preliminary sediment, sedimented at 105000g (5min.), and ribonucleoprotein particles, sedimented at 150000g (70min.), to determine the role of membrane-bound ribosomes. In the adult the ribonucleoprotein particles retained most of the radioactivity, whereas in the young the preliminary sediment was as highly labelled as the ribonucleoprotein particles. 4. The labelled preliminary sediment from young preparations was both ribonuclease- and deoxycholate-resistant, and the nature of this material is discussed in terms of a possible structural component of microsomal membranes.