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Biomedical subjects

D Guber

Publications and source records attributed to D Guber.

9 recordsLinked to original sources

Applicability of risk scores for postoperative nausea and vomiting in adults to paediatric patients.

BACKGROUND: Scores to predict the occurrence of postoperative vomiting (PV) or nausea and vomiting (PONV) are well established in adult patients. The aim of this survey was to evaluate the applicability of risk scores developed and tested in adult patients in 983 paediatric patients (0-12 yr) undergoing various surgical procedures. METHOD: The predictive properties of five models were compared with respect to discriminating power (measured by the area under a receiver operating characteristic curve) and calibration (comparison of the predicted and the actual incidences of the disease by weighed linear regression analysis). RESULTS: The cumulative incidence of PV was 33.2% within 24 h. The discriminating power was low and insufficient in all models tested (0.56-0.65). Furthermore, the predicted incidences of the scores correlated only vaguely with the actual incidences observed. CONCLUSION: Specialized scores for children are required. These might use the history of PV, strabismus surgery, duration of anaesthesia > or =45 min, age > or =5 yr and administration of postoperative opioids as independent risk factors.

Adult↗

Cutaneous malignant melanoma with diffuse intraocular metastases.

A 63-year-old man with a history of cutaneous melanoma and a 3-month history of visual loss in his right eye presented with marked pigmentation of the anterior-segment structures, including trabecular meshwork, iris, and lens surface, with pigment dispersion in the aqueous and anterior vitreous in the right eye. Clinical examination and echography showed no evidence of an intraocular tumor although metastatic melanoma was suspected. Pathologic examination revealed numerous heavily pigmented melanoma cells throughout the anterior segment of the eye, mainly concentrated in the anterior vitreous near the ciliary body. No discrete tumor was found on multiple sections through the globe.

Anterior Eye Segment↗

Radial keratotomy. Clinicopathologic case report.

A 36-year-old man underwent radial keratotomy in both eyes to correct mild myopia, with good visual results. The corneoscleral buttons were obtained following the patient's death 17 months after the second procedure and were examined by light, transmission, and scanning electron microscopy. The average depth of the scars was 86.8% of the corneal thickness, and the deeper portions of the wounds healed by fibrous scarring, with no vascularization. The superficial portion of the incision healed by epithelial ingrowth. The average depth of epithelium within the wounds was 25.3% of the corneal thickness. The presence of epithelium in the wounds of radial keratotomy may play a role in decreased wound strength and flattening. The gradual replacement of epithelium by fibrous scarring may be a factor in the regression of corneal flattening.

Adult↗