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Biomedical subjects

D Greschuchna

Publications and source records attributed to D Greschuchna.

At least 73 records · Page 4Linked to original sources
PubMed1978

[Results of operative therapy for small-cell bronchogenic carcinoma (author's transl)].

In considering the results achieved through resection of small-cell bronchogenic carcinoma, the following factors are taken into account: age, localization, staging of the tumor, lymph node involvement, type of resection and adjuvant chemotherapy and radiotherapy. Furthermore, the fate of patients not operated provides a sound basis for comparison with the surgically treated group. In contrast to other authors, these results indicate that small cell carcinomas with limited dissemination have a relatively good prognosis following resection. The cooperative study undertaken in the German Democratic Republic, which included a very large patient collective, resulted in a similar conclusion.

Adult↗
PubMed1978

[Benign tumors of the lung and pleura (author's transl)].

218 benign tumors of the lung and pleura, 190 of which were operated, are discussed. Little doubt exists about the necessity of operative removal in cases of benign pleuro-pulmonary tumors. Therapeutic management depends on histology, localisation and the extent of growth. The majority of untreated benign tumors have a poor prognosis even if malignant degeneration does not occur. Postoperative prognosis of rehabilitation and resocialization is good.

Adult↗
PubMed1975

[Operative treatment of intralobar pulmonary sequestration (author's transl)].

Among 2700 thoracotomies at the Ruhrlandklinik Essen we have operated eight cases of intralobar pulmonary sequestration. The malformation was found to be situated four times in the left lower lobe, three times in the right lower lobe, and one time in the middle lobe. The only way of curing the suffering consists of surgical interference. At six of eight cases we had to performe a lobectomy, two patients with obviously demarcated alterations have been treated by an exstirpation.

Adolescent↗
PubMed1972

[Hilus biopsy].

Explore the source record for details and available documents.

Biopsy, Needle↗
PubMedDate not supplied

Noradrenaline release in the human pulmonary artery is modulated by presynaptic alpha 2-adrenoceptors.

We used strips of human pulmonary arteries from patients undergoing surgery for lung tumor to investigate whether or not this human tissue (like that of the rabbit) is endowed with inhibitory presynaptic alpha 2-adrenoceptors. The strips were incubated with [3H]noradrenaline and subsequently superfused with physiological salt solution containing cocaine, corticosterone, and propranolol. The electrically (2 Hz) evoked overflow of tritium consisted of 89% unmetabolized [3H]noradrenaline and was abolished by tetrodotoxin or omission of Ca2+ from the superfusion fluid. Unlabeled noradrenaline, adrenaline, and the preferential alpha 2-adrenoceptor agonists B-HT 920, alpha-methylnoradrenaline, and clonidine concentration dependently inhibited the evoked overflow (maximum effect of clonidine lower than that of the other compounds): the alpha 1-selective agonist methoxamine was ineffective. The alpha 2-adrenoceptor antagonists BDF 6143 and rauwolscine facilitated the evoked overflow; the alpha 1-selective antagonist prazosin was ineffective. The concentration-response curve of B-HT 920 for its inhibitory effect on evoked overflow was shifted to the right by rauwolscine. It is concluded that the sympathetic nerve fibres of the human pulmonary artery possess presynaptic alpha 2-adrenoceptors. Stimulation-evoked release of noradrenaline is inhibited by activation and facilitated by blockade of these receptors.

Adrenergic alpha-Agonists↗