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Biomedical subjects

D Green

Publications and source records attributed to D Green.

At least 505 records · Page 28Linked to original sources
PubMed1972

Effects on concurrent performances of a stimulus correlated with reinforcer availability.

A multiple schedule was arranged in which each component consisted of two, concurrent variable-interval schedules of reinforcement. A changeover-key procedure was used, and the components of the multiple schedule were distinguished (initially) by the color of the changeover key. During one component of the multiple schedule, the availability of a reinforcer arranged by one of the variable-interval schedules was marked by an exteroceptive stimulus, provided that that variable-interval schedule was not at the time assigned to the main key. During the other component of the multiple schedule, no reinforcer-correlated stimuli were ever presented. During the latter component of the multiple schedule, the distribution of responses and time for the concurrent variable-interval schedules suggested control by the distribution of reinforcements. During the former component, most main-key responses were emitted on the key in the presence of which reinforcer-correlated stimuli were presented. Changeover rate in the presence of that key color was depressed. The discriminative control over the changeover was easily established and was reversible.

Journal Article↗
PubMed1971

Factors influencing the inhibitory action of anti-inflammatory drugs on carrageenin induced oedema.

1. In a series of experiments carried out over 2(1/2) years, the inflammatory response of the rat hind paw to injected carrageenin was relatively constant, but the anti-inflammatory activity of phenylbutazone was subject to wide variation.2. Phenylbutazone, aspirin and indomethacin were all well absorbed after oral administration, and the resultant plasma drug concentrations were closely similar to those produced when the drugs were administered intraperitoneally.3. The anti-inflammatory effect of the drugs on carrageenin oedema was variable and poorly correlated with log dose and plasma concentration.4. There was a pronounced and linearly correlated increase in the anti-inflammatory activity of phenylbutazone with increasing ambient temperature in the range 5-30 degrees C.5. Variations in relative humidity at constant temperature (20 degrees C) did not influence the anti-oedema potency of phenylbutazone.6. For the precise evaluation of anti-inflammatory activity in carrageenin oedema tests, it is concluded that accurate control of temperature is essential.

Administration, Oral↗