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Biomedical subjects

D Graveron-Demilly

Publications and source records attributed to D Graveron-Demilly.

15 recordsLinked to original sources
PubMed2001

Current awareness.

In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of NMR in biomedicine. Each bibliography is divided into 9 sections: 1 Books, Reviews ' Symposia; 2 General; 3 Technology; 4 Brain and Nerves; 5 Neuropathology; 6 Cancer; 7 Cardiac, Vascular and Respiratory Systems; 8 Liver, Kidney and Other Organs; 9 Muscle and Orthopaedic. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

Magnetic Resonance Spectroscopy↗
PubMed2001

Cramér-Rao bounds: an evaluation tool for quantitation.

The Cramér-Rao lower bounds (CRBs) are the lowest possible standard deviations of all unbiased model parameter estimates obtained from the data. Consequently they give insight into the potential performance of quantitation estimators. Using analytical CRB expressions for spectral parameters of singlets and doublets in noise, one is able to judge the precision as a function of spectral and experimental parameters. We point out the usefulness of these expressions for experimental design. The influence of constraints (chemical prior knowledge) on spectral parameters of the peaks of doublets is demonstrated and the inherent benefits for quantitation are shown. Abbreviations used: CRB Cramér-Rao lower bounds

Animals↗
PubMed2001

Java-based graphical user interface for the MRUI quantitation package.

This article describes the Java-based version of the magnetic resonance user interface (MRUI) quantitation package. This package allows MR spectroscopists to easily perform time-domain analysis of in vivo MR spectroscopy data. We show that the Java programming language is very well suited for developing highly interactive graphical software applications such as the MRUI software. We have also established that MR quantitation algorithms, programmed in other languages, can easily be embedded into the Java-based MRUI by using the Java native interface (JNI). This new graphical user interface (GUI) has been conceived for the processing of large data sets and uses prior knowledge data-bases to make interactive quantitation algorithms more userfriendly.

Algorithms↗
PubMed2001

Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signals.

This article describes a Java-based graphical user interface for the magnetic resonance user interface (MRUI) quantitation package. This package allows MR spectroscopists to easily perform time-domain analysis of in vivo/medical MR spectroscopy data. We have found that the Java programming language is very well suited for developing highly interactive graphical software applications such as the MRUI system. We also have established that MR quantitation algorithms, programmed in the past in other languages, can easily be embedded into the Java-based MRUI by using the Java native interface (JNI).

Algorithms↗
PubMed2001

Age dependence of human gastrocnemius Mg2+: fitting 31P-NMR spectra using quantum mechanics-based prior knowledge.

The age dependence of human gastrocnemius Mg2+ concentration is demonstrated. To quantitate Mg2+ concentration, an original and accurate fitting algorithm using quantum mechanics-based prior knowledge is detailed. In a group of 28 volunteers (14 females) in the age range 5-80 years, pH, PCr/ATP and Pi/ATP values in the gastrocnemius were 7.02 +/- 0.02 pH, 4.16 +/- 0.33 and 0.13 +/- 0.02, respectively and independent of age and sex. By contrast, intracellular Mg2+ concentration (mM) decreased linearly (p < 0.05) with age (Mg2+ = 0.7803 +/- 0.0247-0.0027 +/- 0.0005 * age). No difference was found between sexes. From these results, it follows that care must be taken when comparing muscle Mg2+ data from subjects of different age. The hypothesis can be put forward that during aging insufficient intake and/or increased depletion of Mg2+ (e.g., intestinal hypoabsorption or urinary leakage) may affect the musculoskeletal system.

Adenosine Triphosphate↗
PubMed2000

Cramer-Rao bound expressions for parametric estimation of overlapping peaks: influence of prior knowledge

We have derived analytical expressions of the Cramer-Rao lower bounds on spectral parameters for singlet, doublet, and triplet peaks in noise. We considered exponential damping (Lorentzian lineshape) and white Gaussian noise. The expressions, valid if a sufficiently large number of samples is used, were derived in the time domain for algebraic convenience. They enable one to judge the precision of any unbiased estimator as a function of the spectral and experimental parameters, which is useful for quantitation objectives and experimental design. The influence of constraints (chemical prior knowledge) on parameters of the peaks of doublets and triplets is demonstrated both analytically and numerically and the inherent benefits for quantitation are shown. Our expressions also enable analysis of spectra comprising many peaks. Copyright 2000 Academic Press.

Journal Article↗
PubMed1999

The beneficial influence of prior knowledge on the quantitation of in vivo magnetic resonance spectroscopy signals.

RATIONALE AND OBJECTIVES: This work concerns quantitation of in vivo magnetic resonance spectroscopy signals and the influence of prior knowledge on the precision of parameter estimates. The authors point out how prior knowledge can be used for experiments. METHODS: The Cramer-Rao lower bounds formulae of the noise-related standard deviations on spectral parameters for doublets and triplets were derived. Chemical prior knowledge of the multiplet structures was used. RESULTS: The benefit of chemical prior knowledge was estimated for doublet and triplet structures of arbitrary shape. Then, it was used to quantify in vivo 31P time-series signals of rat brain. CONCLUSIONS: Analytic expressions of errors on parameter estimates were derived, enabling prediction of the benefit of prior knowledge on quantitation results. These formulae allow us to state, for a given noise level, if the quantitation of strongly overlapping peaks such as adenosine triphosphate multiplets can be performed successfully.

Adenosine Triphosphate↗
PubMed1999

MR spectroscopy of bilateral thalamic gliomas.

This study reports the MR spectroscopic patterns of two patients with bithalamic glioma. In one patient, phosphorus (31P) MR spectroscopy was performed. In both patients, the proton MR spectroscopic scans showed an increased creatine-phosphocreatine peak in the tumor. In the patient who underwent 31P-MR spectroscopy, an increased phosphocreatine peak was also observed. This group of thalamic tumors may be distinguished from other gliomas clinically, radiologically, and metabolically.

Adult↗
PubMed1998

Absolute metabolite quantification by in vivo NMR spectroscopy: V. Multicentre quantitative data analysis trial on the overlapping background problem.

The goal of this study was to establish the best approach for quantifying nuclear magnetic resonance (NMR) lines, that in the frequency domain are overlapping with broad, unwanted background features. To perform the quantitative data analysis in a controlled way, test signals were designed and utilised, derived from two different real-world in vivo nuclear magnetic resonance signals. One of the main conclusions of the study was that the quantification methods currently available to the biomedical research groups can deliver the correct values of the quantitative parameters, but that great care should be taken in using optimal input parameters for the computer programs concerned.

Bayes Theorem↗
PubMed1996

SRS-FT, a Fourier imaging method based on sparse radial scanning and Bayesian estimation.

A new 3D Fourier imaging method based on sparse radial scanning (SRS-FT) of k space is proposed. It allows acquisition of FIDs and is therefore well suited to imaging objects with very short T2. Use of a Bayesian procedure allows (1) an important reduction of scan time to below that of the projection-reconstruction (PR) method by reducing the number of "Cartesian radial" encoding directions, and (2) a good image quality by estimating missing and corrupted Cartesian samples. SRS-FT images reconstructed from FIDs are compared to conventional FT and PR images.

Bayes Theorem↗
PubMed1992

Automatic in vivo NMR data processing based on an enhancement procedure and linear prediction method.

A new data processing method for in vivo NMR data quantitation is presented. This method (EPLPSVD) is based on the enhancement procedure (EP) proposed by J. A. Cadzow (IEEE Trans. Acoust. Speech Signal Process. 36, 49, 1988) followed by the usual linear prediction method using the singular value decomposition (LPSVD). The evaluation of this protocol is performed using synthesized 31P signals with different signal-to-noise ratios. A Monte-Carlo simulation as a function of signal-to-noise ratio (SNR) has proved that EPLPSVD leads to unbiased estimated values of parameters. Then the Cramer-Rao method yields reliable confidence intervals for the estimated parameters. The estimates of NMR parameters using EPLPSVD are reliable and accurate for SNR > or = 1.2 while the LPSVD method failed for SNR < or = 4. This protocol is applied to analyze automatically a series of 31P free induction decays obtained from the human gastrocnemius muscle during exercise. Spectral parameters with their confidence intervals, curves of relative intensity variations in phosphocreatine and inorganic phosphate, and pH curves are automatically provided.

Adenosine Triphosphate↗
PubMedDate not supplied

Improving data acquisition parameters of 31P in vivo spectra for signal analysis in the time domain.

To obtain reliable NMR quantitation, experimental cautions concerning data acquisition must be taken when using automatic predictive calculations. For this study, 2000 31P in vitro and in vivo spectra were processed, using the enhancement procedure with linear prediction using singular value decomposition (EPLPSVD) method, and analyzed. The effects of quadrature detection modes (simultaneous or sequential), of the number of time-domain samples used are investigated and experimental conditions such as sample motions and spectral width are discussed.

Algorithms↗