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Biomedical subjects

D Gozal

Publications and source records attributed to D Gozal.

At least 163 records · Page 9Linked to original sources
PubMed1991

[Problems raised by the administration of a peridural block in patients receiving anticoagulant therapy].

More and more patients likely to get an epidural block are treated with anticoagulant or antiplatelet drugs. An epidural hematoma may be consecutive to an injury of the epidural venous plexus. The mechanisms of action of the different drugs are reviewed. The bleeding time is not an infallible indication of aspirin or other non steroidal antiinflammatory drugs platelet defect. The protocol used in our institution for the administration of an epidural block in this group of patients is discussed.

Anesthesia, Epidural↗
PubMed1991

[The use of 0.5% bupivacaine by infiltration for analgesia during thyroidectomies].

We studied the postoperative analgesia in 25 patients scheduled for a thyroidectomy or a parathyroidectomy. In 15 patients we used wound infiltration of bupivacaine 0.5%. In both groups we compared the pain score and the analgesic drugs administered after the surgery, within the first 24 hours. We found that wound infiltration is a very efficient way to prevent and to treat the postoperative pain.

Adolescent↗
PubMed1991

Prevalence of the sickle cell trait in an athletic West African population.

The prevalence of the sickle cell trait in a school for elite young athletes in Cameroon, West Africa, was examined in order to evaluate whether the choice of an athletic career was influenced by its presence. The presence of hemoglobin AS was found in 27 of the 145 students attending the school (18.6%). Since the frequency of the sickle cell trait in the general Cameroonian population is 17.3%, we conclude that its presence is not a determinant factor involved in the choice of a professional sportive activity.

Cameroon↗
PubMed1990

Diffuse neonatal haemangiomatosis: successful management with high dose corticosteroids.

We report two cases of diffuse neonatal haemangiomatosis. The multiple cutaneous lesions were associated with massive hepatic involvement and congestive heart failure in one, while in the other laryngeal haemangiomas caused stridor and inspiratory distress. A significant regression in vascular lesions was achieved with high dose corticosteroid therapy.

Administration, Oral↗
PubMed1990

Comparison of unbound and total serum theophylline concentrations with those of stimulated and unstimulated saliva in asthmatic children.

Unstimulated saliva, citric acid stimulated saliva, and serum were collected from 31 asthmatic children taking theophylline. Salivary theophylline concentrations, and total and unbound serum theophylline concentrations were measured. The correlation coefficients between both types of saliva, and total and unbound serum theophylline were all statistically significant (p less than 0.001). The highest correlation coefficients were obtained with stimulated saliva and total serum concentrations (r = 0.98), and stimulated saliva and unbound serum (r = 0.96). The coefficients when unstimulated saliva was compared to either total or unbound serum concentrations were 0.90 and 0.89, respectively. Serum binding of theophylline averaged 58.1%. Unstimulated saliva had a higher mean theophylline concentration than stimulated saliva. The results suggest that salivary monitoring using stimulated saliva may be used to predict serum concentrations with a high degree of confidence when the saliva levels are substantially lower than, higher than, or in the middle of the therapeutic range, but there is a considerable degree of uncertainty when the salivary values are near the lower or upper end of the therapeutic range.

Adolescent↗
PubMed1990

Water, electrolyte, and endocrine homeostasis in infants with bronchiolitis.

Twenty-two of 23 consecutive infants with bronchiolitis, 5.5 +/- 3.5 mo of age, showed a 1.9 +/- 1.4% increase in body weight, increased urinary osmolality of 737 +/- 193 mmol/L with low plasma osmolality of 275 +/- 4 mmol/L, and markedly elevated plasma antidiuretic hormone (ADH) levels of 114 +/- 225 pg/mL. Increased ADH, which usually suppresses plasma renin activity, was associated with increased plasma renin activity of 11-55 ng angiotensin 1/mL/h (normal for age less than 10 ng angiotensin 1/mL/h). Hyperaldosteronism was evident from the low fractional excretion of sodium of 0.27 +/- 0.2% and high fractional excretion of potassium of 21 +/- 15%. Serum sodium concentrations were normal. All of the pathologic findings returned to normal when the bronchiolitis subsided. A control group of 10 infants with nonrespiratory febrile illness did not show any of the above abnormalities. Thus, bronchiolitis of infancy is characterized by both increased ADH secretion and hyperreninemia with secondary hyperaldosteronism, which induce water retention but counterbalance each other with respect to serum sodium. Increased ADH secretion as well as increased plasma renin activity are not "inappropriate," but rather suggest a response to the perception of hypovolemia by intrathoracic receptors. We therefore conclude that the clinical management of bronchiolitis requires close monitoring of body wt and plasma osmolality-urinary osmolality relationship; serum sodium levels may be misleading.

Blood Volume↗
PubMed1990

[Computerized electroencephalographic monitoring in anesthesia].

The computerized electroencephalogram monitor provides a simple interpretation of the standard EEG trend. In the operating room, this compact EEG monitor is convenient and the trend is easy to read for a non-specialist user. EEG monitoring is especially indicated in carotid endarterectomy for the detection of ischemic event during surgery. The use of this monitor should be recommended for high risk patients (cardiac surgery, cerebral aneurysm surgery, controlled hypotension) to determine the adequate depth of anesthesia and to perform a stress-free anesthesia when the anesthetic drug is given by titration according to the decrease in the awakening electrical cerebral activity.

Anesthesiology↗
PubMed1988

Environmental overheating as a cause of transient respiratory chemoreceptor dysfunction in an infant.

A central hypoventilatory state developed in a 6-month-old boy with environmentally induced hyperthermia. The condition subsided within 24 hours of mechanical ventilation. Hypoxic and hypercapneic challenges performed 2 weeks later showed complete resolution of the respiratory chemoreceptor dysfunction. The damage to the CNS caused by accidental hyperthermia in general, and more specifically to the respiratory center, and its possible etiologic role in the pathophysiology of sudden infant death syndrome are discussed.

Chemoreceptor Cells↗
PubMed1986

Necrotizing fasciitis.

Necrotizing fasciitis was diagnosed in 16 patients during the years 1980 to 1984. All patients were managed by a uniform protocol consisting of radical excisional surgery, intravenous antibiotics, and hyperbaric oxygen therapy. An overall mortality rate of 12.5% was achieved. In view of the encouraging results, this therapeutic regimen is highly recommended.

Adult↗
PubMed1985

Hyperbaric oxygen therapy for Fournier's gangrene.

Soft-tissue infections with tissue necrosis, due to mixed aerobic and anaerobic organisms, are an accepted indication for hyperbaric oxygen (HBO) therapy. A unique type of such infection is Fournier's gangrene. This condition represents a serious risk to life and patients should be treated rapidly and aggressively. We treated three such cases by HBO. All three patients recovered from the infection, although one died later from renal and pulmonary complications.

Adult↗