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Biomedical subjects

D Gosset

Publications and source records attributed to D Gosset.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

[Double heart valve replacement disclosing antiphospholipid syndrome].

In patients with systemic lupus erythematosus (SLE) heart valve lesions are usually discovered at echocardiography; their haemodynamic repercussions are uncommon, and valve replacement is exceptional. We report the case of a woman who had undergone aortic and mitral valve replacement before antiphospholipid antibodies were found associated with 4 ARA criteria of SLE. Histopathological examination confirmed the diagnosis of Libman-Sachs specific endocarditis. The presence of antiphospholipid antibodies leads to a discussion of their role in the physiopathology of the heart valve lesions and vascular accidents that occurred in this patient. The overlap observed between the diagnostic criteria of SLE and those of primary antiphospholipid syndrome is discussed. Heart valve lesions may be one of the modes of access to the antiphospholipid syndrome.

Adult↗
PubMedDate not supplied

[Peripheral nerve diseases disclosing Horton's disease (2 cases)].

Peripheral nerves are rarely involved in Horton's disease, and when peripheral neuropathy predominates in the clinical complex it is sometimes a source of diagnostic errors. We report two cases of giant cell arteritis revealed by peripheral neuropathy.

Aged↗
PubMedDate not supplied

[Adult Still's disease. A too often unrecognized illness. A study of a series of 11 cases].

The authors report eleven new cases of adult Still's disease diagnosed during the last 5 years. This rare, though not exceptional, disease of unknown pathogenesis is difficult to diagnose in the absence of specific sign; it is in fact diagnosed by elimination. The clinical, laboratory and anatomical findings, as well as the treatment and outcome of these 11 cases are described, and this is followed by a discussion of the nosological, therapeutic and above all prognostic problems raised by the disease.

Adolescent↗
PubMedDate not supplied

Case report: recovery of Calliphora vicina first-instar larvae from a human traumatic wound associated with a progressive necrotizing bacterial infection.

Human myiasis caused by Calliphora vicina is rare in Europe. Here we report a case of C. vicina infection occurring in the traumatic leg wound of a healthy 21-year-old man. Firstly, a progressive necrotizing infection developed in the wound despite administration of antibiotics. Aeromonas hydrophila was isolated from the wound samples. Secondly, during debridement, C. vicina first-instar larvae were isolated from the wound. To our knowledge, this is the first European case of C. vicina wound myiasis associated with severe A. hydrophila infection.

Adult↗
PubMedDate not supplied

Serum amyloid A concentrations in giant-cell arteritis and polymyalgia rheumatica: a useful test in the management of the disease.

A prospective clinical study of 23 patients with giant-cell arteritis (GCA) and/or polymyalgia rheumatica (PMR) was undertaken in order to assess the behaviour of the non-specific markers of the disease activity, the erythrocyte sedimentation rate (ESR) and other acute phase markers, particularly the C-reactive protein (CPR) and serum amyloid A apolipoprotein (apo SAA) levels during induction of disease remission by prednisone therapy, and possible further recurrence of GCA and/or PMR. The apo SAA measurement is more sensitive than the CRP measurement in determining disease activity (97% and 61%, respectively). The specificity of apo SAA is greater than ESR in the determination of inactive disease (86% and 77%, respectively). In some cases with clinically active disease the ESR and CRP were normal, whereas the apo SAA was always elevated. We conclude that the apo SAA measurement in combination with clinical data and other laboratory parameters may be useful in the management of GCA and/or PMR.

Acute-Phase Proteins↗