Biomedical subjects
Publications and source records attributed to D Glaser.
A bilateral fetal hydrothorax was recognized in the second pregnancy of a 30-year-old woman. Because of increasing pleural effusions, fetal hydrops and hydramnion a cesarean section was performed in the 31st week of pregnancy. The child died of pulmonary hypoplasia. The ante- and postnatal diagnosis and therapy and the poor prognosis of bilateral congenital hydrothorax are discussed.
We describe the clinical features of Robinow syndrome in the first child of a consanguineous Turkish couple. This observation supports the view that severe vertebral anomalies are a feature of the autosomal-recessive form of Robinow syndrome.
In a 41-year-old VII-gravida, I-para, the husband's reciprocal translocation of the chromosomes 1 and 18 as well as a partial identity of the marital partner in the HLA-system may have been the underlying causes for five abortions. In the 7th pregnancy, a prenatal chromosome analysis was performed as well as an immunotherapy with paternal lymphocytes, when uterine bleeding occurred. After termination of bleeding, the pregnancy continued without any complication. Our case report demonstrates the importance of an extensive search for causes leading to recurrent abortions not only with regard to diagnosis but also with regard to therapy in pregnancy.
We report on a 54-year-old patient with multiple cutaneous, lung and liver metastases. The primary tumour is a malignant melanoma of the vagina, who developed within one year after the last gynaecological examination. Our case report is another example for the poor prognosis of this rare vaginal tumour.
Ninety-one children aged 3-6 yrs were observed and video-recorded playing with the anatomically correct dolls in unstructured play settings. Parental permission had been obtained. The children's emotional, behavioural and overall play responses were rated. Whilst the dolls' difference from other dolls was clearly noticed, they did not traumatise the children, most of whom incorporated the dolls in imaginative play. Only five children's play with the dolls showed any sexualized quality, in three the source of sexual knowledge becoming apparent. Whereas the absence of sexualized play does not reliably exclude abuse, we suggest that explicit sexual play with the dolls may well arise from previous exposure to explicit sexual information or activity.
Segregation was studied by measuring the positions of autoradiographic grain clusters in chains formed from single cells containing on average less than one radiolabeled chromosome strand. The degree to which chromosomal and cell wall material cosegregated was quantified by using the methods of S. Cooper and M. Weinberger, dividing the number of chains labeled at the middle. This analysis indicated that in contrast to chromosomal segregation in Escherichia coli and, in some studies, to that in gram-positive rods, chromosomal segregation in Streptococcus faecium was slightly nonrandom and did not vary with growth rate. Results were not significantly affected by strand exchange. In contrast, labeled cell wall segregated predominantly nonrandomly.
The buoyant density in rapidly growing Streptococcus faecium 9790 cells varies over the cell cycle, in contrast to the density in Escherichia coli. Buoyant density in S. faecium was measured by using Percoll (Pharmacia Fine Chemicals, Piscataway, N.J.) density gradients. We found that the mean and coefficient of variation of the population density increased with growth rate; and within a population, the mean cell volume, which was measured electronically, increased with density. These results were compared with electron microscopic measurements of the size distributions of cell wall growth sites within each fraction of the density gradient. As the density increased within a population, the frequency of large cells increased and the frequency of newly initiated cell wall growth sites increased. These effects were more marked as the growth rate increased. Next, these data were regrouped by cell size by using the size of the central growth site as an index of cell cycle stage. Each frequency value was weighted by the proportion of the population represented by that density fraction. Then, the average buoyant density was calculated for each value of cell size. In all cell populations, the density decreased and then increased as the central site enlarged. Peripheral growth sites were initiated as density reached a maximum. At faster growth rates, density increased more steeply, and new peripheral growth sites opened up at a higher frequency. We suggest that the rate at which density increases during the cell cycle correlates with the initiation of new cell wall growth sites.
The buoyant density of whole cells of Streptococcus faecium varies with growth rate and during the cell cycle. Two possible explanations for this were explored: (i) the density of cell walls may vary, and (ii) the proportions of wall and cytoplasm may vary. We tested the first possibility by isolating walls from chilled, unfixed populations of S. faecium cells and fractionating them on Percoll density gradients. Mean cell wall density averaged 4% less than whole-cell density and did not vary significantly with growth rate. In addition, walls isolated from heavy and light fractions of a population of cells did not differ significantly in density. Thus, variation in the density of isolated cell walls could not account for the observed variation in whole-cell density within or between populations. Using previously published measurements of the physical dimensions of S. faecium cells, we also found that the relative proportions of wall and cytoplasm (see the second possibility above) could not account for the observed changes in whole-cell buoyant density.
Three polymorphic DNA markers linked to the locus of Norrie disease were used for indirect genotype analysis in a ten-wk-old fetus at risk for the disease. When haplotypes of the family members and the estimated recombination frequency between Norrie gene and each of the DNA marker loci DXS7, DXS84, and DXS146 were taken into account, the risk that the fetus had inherited the mutation was about 1%.
We describe a postmenopausal woman with 45,XO/46,XX/47,XXX mosaicism who presented with a Sertoli-Leydig cell tumour and a past history of habitual abortion. The cytogenetic finding is discussed in relation to the etiology of the tumour and of the recurrent abortions.
We report on the third pregnancy of a 41-year-old patient with familial hypercholesterolemia. After preceding angina pectoris symptoms she had her first myocardial infarction at an age of 37. Thereafter she had no complaints under medicinal and dietary treatment. During her third pregnancy angina pectoris symptoms occurred again and finally a myocardial re-infarction caused her death. Our case report shows, that the hemodynamic alterations in pregnancy can aggravate the patient's situation even in prepartally uncomplicated coronary diseases.
We report on a postpartally decreased girl with several malformations: turricephalus, deep root of the nose, prognathism, choanal atresia, low-set dysplastic ears, fourth additional blood vessel originating from the thoracic aorta. Nearly 70% of the placenta consisted of multiple chorioangiomas. A possible correlation between fetal malformations and placental chorangiomas is discussed. There is no valuable reference to a hereditary component in the development of chorioangiomas.
We report on an acardius in a 47-year old tenthgravida. The postnatally detected acardius did not cause any obstetrical problems. The following theory seems to be the most suitable explanation for the development of an acardius: in a twin (multiple) pregnancy with blood vessel anastomoses between both twins, a twin with a haemodynamic advantage supplies the other one with oxygen-deprived blood; the latter thus becomes an acardius.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.