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Biomedical subjects

D Giunta

Publications and source records attributed to D Giunta.

5 recordsLinked to original sources
PubMed1995

Influence of indomethacin on bone turnover related to orthodontic tooth movement in miniature pigs.

The purpose was to evaluate the influence of a prostaglandin inhibitor, indomethacin, on the tissue reaction related to orthodontic tooth movement. Sixteen miniature pigs were chosen for the study, eight of which received indomethacin perorally every day of the 39-day observation period. Sentalloy expansion springs (GAC, Central Islip, N.Y.) delivering 100 cN were inserted on a segmented arch between the central lower incisors. Intravital labeling with tetracycline was used for the evaluation of the rate of bone formation. After the pigs were killed, the bone turnover was evaluated on undecalcified methacrylate embedded sections and on microradiographs. The histomorphometric analysis of bone turnover revealed that the relative extent of resorption surfaces was decreased significantly in the indomethacin treated animals. Formation surfaces were also decreased although not significantly. The bone turnover, but not the mineralization rate, was influenced. The results corroborate the recommendation that prostaglandin inhibitors should be avoided during orthodontic treatments.

Administration, Oral↗
PubMed1993

Dentin formation in miniature pigs with special reference to indomethacin and orthodontic treatment.

The rate of dentin mineralization and the influence of indomethacin on the dentin mineralization rate during orthodontic treatment was determined in miniature pigs by intravital labeling with tetracycline. The results demonstrated that the dentin mineralization rate in the control animals was 3.8 microns/day, a rate corresponding to that of human teeth. Both indomethacin and orthodontics had an effect on the dentin mineralization rate, indomethacin reducing and orthodontic forces increasing it. In combination, the two factors neutralized each other.

Animals↗
PubMedDate not supplied

[Molar uprighting: biomechanical considerations].

Various biomechanical systems for the molar uprighting have been described. The Authors analyze the force system delivered on the molar and on the anchorage unit. The biomechanical considerations are emphasized in each single case.

Dental Stress Analysis↗