[Invitation to the study of the history of medicine in Cogne and the Valle d'Aosta. I. Piero Giacosa].
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Biomedical subjects
Publications and source records attributed to D Giordano.
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The authors have investigated the chemotactic ability of C. albicans toward macrophages and polymorphonuclears. Experiments, carried out by modified Boyden chamber, lead to isolate a chemotactic agent, considered either a moderate cytotaxin, or an excellent cytotaxigen.
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The AA. have studied biological effects of laser radiation and methylene blue (MB) on Salmonella typhimurium TA 1538 strain. Their results show low lethal effect of laser radiation directly proportional to administered dose. This effect is more evident in the only MB treatment. Lethal effect persisted, although non directly proportional with combined treatment laser and MB. Some treatments have not demonstrated mutagenetic effect. A new set of trials they are making on Salmonella typhimurium TA 100 strain with plasmid pK M 101 that give to strain greatest susceptibility for mutagenetic agents.
In this second note, the AA. have studied biological effect of laser radiation and methylene blue on Salmonella typhimurium TA 100 strain with greatest susceptibility for mutagenetic agents. Their results show a biological effect of laser radiation, of methylene blue like to those obtained for TA 1538 strain, nevertheless greatest susceptibility of TA 100 strain because carrier of plasmid.
The AA. have studied biological effects of Laser radiation and Haematoporphyrin (HPD) on Salmonella typhimurium TA 100 strain. Their results do not show a growth of letal effect that they demonstrated on antecedent trials, only dependent from Laser radiation. Nome mutagenetic effect was demonstrated. They think that HPD is not capable of binding or penetrating in bacterial cell owing to complexity of bacterial capsule and wall; therefore HPD can not increase Laser radiation effect, though its photodynamic action.
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The effects of cis-Platinum, a new antitumor drug, on guinea pig polymorphonuclear functions related to subplasmalemmal fibrillar structures, were investigated. The compound markedly decreased chemotaxis. Zymosan particles engulfment and degranulation. The depression of these leucocyte activities adds to the already known drug induced myelotoxicity .
An electrophysiological study of "blink reflex" and "jaw reflex" was carried out on 20 sicilian patients with "definited" Multiple Sclerosis. The R1 component of the "blink reflex" was abnormal in 13 patients on 20 (65%), the R2 component in 8 patients on 20 (40%). Considering together the R1 and R2 responses, the abnormal percentage was 75%. The "jaw reflex" showed abnormal responses in 5 patients on 20 (25%). Considering both the "blink reflex" and "jaw reflex", the pathological percentage was 75%, in order that no patients had isolated changes of the "jaw reflex". The simultaneous study of the two reflexes does not increase the probability to prove pathological responses. The frequency of the clinically silent brain-stem lesions in our patients was not substantially different from that showed by other authors on different populations.
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