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D Gibbons

Publications and source records attributed to D Gibbons.

74 records · Page 5Linked to original sources

Gauging pesticide exposure of handlers (mixer/loaders/applicators) and harvesters in California agriculture.

Agricultural workers acquire pesticide exposures as a function of the properties of the product, crop, and work task. Mixer/Loaders and Applicators have greater exposure potential than other workers since concentrated formulations are handled during preparation and application of spray mixes. Exposures can be estimated using passive dosimetry and biological monitoring. Measured exposures are invariably less than estimates derived from surrogate data due to a series of conservative "worst case" assumptions and exposure estimates derived from small portions of the work day. Data have also been collected to estimate the exposure potentials of harvesters. We are establishing a set of empirical transfer factors (cm2/h) that can be used to estimate daily harvester exposure (transfer factor x dislodgeable foliar residue x hours). These estimates are important to current efforts to establish exposure-based reentry intervals to protect against acute and chronic toxicity.

Agriculture↗

TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy.

Our work has shown that TNF alpha is produced by cultured mononuclear cells from rheumatoid arthritis joints and appears to regulate the production of IL-1. Immunohistochemical examination has shown the presence of TNF alpha in the synovium, e.g. in the lining layer, some endothelial cells and most importantly, in the cells in the cartilage pannus junction. TNF receptors (both p55 and p75) have a similar distribution, thereby suggesting that TNF has the potential for autocrine and paracrine activity in the joint. The concept that TNF alpha is pathogenic in inflammatory arthritis has been validated by showing that neutralizing monoclonal anti-TNF antibodies significantly attenuate collagen-induced arthritis in mice. In preliminary trials in rheumatoid patients anti-TNF appears to have an impressive effect on indices of disease activity including C-reactive production and serum amyloid-A production. TNF alpha appears to be a relevant therapeutic target in rheumatoid disease.

Animals↗