Search PubMed⌕ Search

Biomedical subjects

D Gericke

Publications and source records attributed to D Gericke.

At least 19 recordsLinked to original sources
PubMed1996

Efficacy of low-molecular-weight heparin and unfractionated heparin to prevent adhesion of human prostate and bladder carcinoma and melanoma cells to bovine endothelial monolayers. An in vitro study and review of the literature.

Adherence of human prostate carcinoma (PC 3, DU 145), bladder (647 V, J 82) carcinoma and melanoma (RPMI-8252) cell lines to plastic and bovine endothelial monolayers (BEM) was tested in the presence of 0.5, 1, 5, 10, 20 IU of low-molecular-weight heparin (LMWH), unfractionated heparin (UFH) or saline as a control. Culture medium was supplemented either with 5% fetal calf serum or with human plasma. Floating tumor cells were counted after 2, 4, 24 h of culture in microtiter plates without BEM and after 1.5, 3 and 24 h of culture on BEM. Twenty IU of LMWH increased the numbers of bladder carcinoma cells adhering to BEM as did 20 IU of UFH in cultures of DU 145 prostate carcinoma and RPMI-8252 melanoma cells. LMWH obviously does not prevent human prostate and bladder carcinoma and melanoma cells from adhering to BEM more effectively than UFH. The in vivo effect of UFH and perhaps also LMWH that hinders intravenous tumor cell colonization in blood vessels obviously does not depend on the interaction with endothelial cells alone.

Adult↗
PubMed1992

[Early diagnosis saves human lives--on the status of colorectal tumors].

UNLABELLED: Colorectal cancers are on rang 3 of the malignant tumors in men and in women in incidence as well as in mortality. The only method to save more patients with these tumors is the early detection. It is to realize at its best by combination of digital rectal examination (DRE), testing for blood in feces and sigmoidoscopy. About DRE nothing is to discuss. The lack of a method without a high percentage of false negative and false positive results is the main problem of testing blood in feces. But the existing methods have to be used until more effective ones will be developed. Method no 3 is the sigmoidoscopy with the new generation of flexible instruments. Doctors have to prefer them because their use is easier, more informative and better tolerable for patients as the old rigid rectoscops. An additional method to evaluate the tumor expansion during surgical treatment is the endoscopic ultrasound examination. It enables the surgeon to look through the colorectal wall for evaluation of the tumor-spreading. There is no doubt, that the surgical treatment is the most effective. It can save around 90% of tumor patients if the tumor is detected in an early stage. The results of chemotherapy are not convincing at all. 5-fluorouracil (5-FU) seems to be the most effective but not curing drug, possibly in combination with immunemodulators. IN CONCLUSION: Colorectal cancer, early detection is the key. If the patient, the practicien and the surgeon will have this in mind, 50,000 pats with colorectal cancer more could be saved this year in the USA. Similar results should be possible in our country also.

Colorectal Neoplasms↗