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Biomedical subjects

D Gaon

Publications and source records attributed to D Gaon.

13 recordsLinked to original sources
PubMed1998

Principles of antimicrobial therapy.

It has been 2500 years since the Chinese began applying moldy soybean curd to cure skin infections. Technology today has refined the benefits of antibiotic-forming molds and bacteria and has greatly increased the number of antimicrobial drugs available to combat infection. Understanding the principles fundamental to rational therapy with these drugs will ensure the best of possible outcomes.

Animals↗
PubMed1989

Effect of dexamethasone on secretion of luteinizing hormone and testosterone in the boar.

Eight adult, Yorkshire-Landrace crossbred boars were used to evaluate the effects of the synthetic glucocorticoid, dexamethasone (DXM) on the secretion of luteinizing hormone (LH) and testosterone. Four treatments of 4 d each were administered: 1) 2 ml i.m. of 0.9% (w/v) NaCl solution (control); 2) DXM (2 ml i.m. as a dose of 50 mug/kg body weight, every 12 h); 3) DXM plus gonadotropin releasing hormone (GnRH; 50 mug in 1 ml i.m. every 6 h); 4) 2 ml NaCl solution i.m. plus a single dose of 50 mug i.v. GnRH. Blood samples were collected twice daily from an indwelling jugular vein catheter for 3 d and at 15 min intervals for 12 h on the fourth day. DXM treatment resulted in lower (P M0.01) testosterone values in samples collected twice daily. More frequent sampling on Day 4 revealed that DXM reduced (P<0.01) the number of pulsatile increases of LH in plasma, although the individual mean pulse areas did not fiffer between the NaCl- and DXM-treated groups. This was associated with a decreased pulse frequency of testosterone (P<0.05). GnRH plus DXM treatment caused a significant elevation (P<0.05) in mean values as well as in the mean pulse area and in the total of the individual pulse areas of LH. Pulse area and mean concentrations of testosterone were also increased (P<0.01) when GnRH was given concurrently with DXM. Comparison of a single injection of GnRH when NaCl was being administered (Treatment 4) to one of the injections of GnRH (Day 4, 0800 h, Treatment 3) revealed a subsequently greater (P<0.01) pulse area in LH above base-line during DXM treatment (7.67 +/- 1.17 ng/ml) than during the NaCl (4.17 +/- 0.73 ng/ml) treatment period. This was reflected in a greater (P<0.01) pulse increase of testosterone following the LH pulse in boars treated with DXM. It is concluded that DXM treatment in the boar can reduce the pulse frequency of LH secretion, presumably by affecting GnRH secretion, but it has less effect directly on pituitary LH synthesis and release.

Journal Article↗
PubMed1989

Effect of dexamethasone on gonadotrophin secretion in the gonadectomized sow and boar.

Saline solution or dexamethasone (DXM, 35 micrograms/kg bodyweight) was injected intramuscularly twice daily for four days into five ovariectomized sows and five castrated boars. Blood samples from an indwelling jugular vein catheter were taken at 15 min intervals for 12 h prior to DXM injection and on the fourth day of treatment in order to compare the effect on variables describing the pulsatile secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH). Dexamethasone treatment caused a decrease (p less than 0.05) in the number of pulsatile episodes of LH secretion in both gonadectomized boars and sows resulting in a significant decrease in mean concentrations. Follicle stimulating hormone secretion parameters appeared to be unaffected by DXM injection in both groups of animals. It is concluded that previously described differences in LH suppression in boars and sows given glucocorticoids may be attributed to the influence of gonadal hormones.

Animals↗
PubMed1981

Pancreatic lesions in shock and their significance.

The pancreas was examined histologically in 146 cases of patients dying of shock. The finding of morphological evidence of disseminated intravascular coagulation (DIC) in the pancreas supports the opinion that the pancreas in highly sensitive to disturbances of blood perfusion. The presence of DIC combined with a variety of pathological lesions in the exocrine ad endocrine pancreas was sufficiently characteristic to justify use of the term " shock pancreatitis". The relative scarcity of data hitherto available on pathological changes in the pancreas caused by shock can be ascribed to changes in the management of shock. It is concluded that the pancreatic lesions described in this study could influence the outcome in shock treated by modern methods of resuscitation.

Disseminated Intravascular Coagulation↗
PubMed1978

Potent reduction of basal acid output produced by meperidine.

Meperidine is a potent narcotic related chemically and pharmacologically to morphine and atropine. To examine its gastric antisecretory activity a study designed to test the effect of meperidine on basal acid secretion was carried out: 100 mg of meperidine given intramuscularly reduced basal acid output (BAO) by 66.3% at 1 hr (P less than 0.001), 64.9% at 2 hr (P less than 0.001), and 44.9% at 3 hr (P = 0.005). This degree of reduction of BAO by this dose of meperidine did not differ from that produced by 30 mg of propantheline intramuscularly. These results demonstrate that meperidine in standard classical doses is a potent inhibitor of BAO in man.

Adolescent↗