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Biomedical subjects

D Gall

Publications and source records attributed to D Gall.

9 recordsLinked to original sources
PubMed1989

[Cytologic differentiation between the autonomous and autoimmune type of diffuse hyperthyroid goiter: correlation with TSH receptor antibodies, microsomal antibodies and infiltrative ophthalmopathy].

A group of 101 patients with diffuse hyperthyroid goiter has been studied. Sixty-seven patients showed significantly increased level of antibodies to the TSH receptor (TBIAb), 48 patients had positive microsomal antibodies (MAb) and 41 patients had infiltrative ophthalmopathy. On the basis of cytologic analysis of the whole group, the patients were divided into two groups. Group A (n = 51, autonomous form?) was characterized by follicular cell proliferation, while group B (n = 50, autoimmune form?) was characterized by lymphocyte infiltration or follicular cell proliferation with lymphocyte traces. Cytologic findings were correlated with autoimmunity markers (TBIAb, MAb, infiltrative ophthalmopathy); multiple correlation factor was 0.17. In conclusion, cytologic classification into autonomous and autoimmune hyperthyroidism form, except by microsomal antibodies, is not followed by other autoimmunity markers.

Adolescent↗
PubMed1988

Monitoring calcium intake in osteoporosis by assay of nephrogenous cyclic AMP.

We studied the relationship between urinary and nephrogenous cyclic adenosine monophosphate (CAMP) and intake of calcium in patients with clinical osteoporosis. Serum and urinary Ca, alkaline phosphatase, and CAMP were measured by standard techniques. Lumbar mineral density was assessed by dual photon absorptiometry. Mean (+/- SD) urinary and nephrogenous CAMP was 4.6 +/- 1.4 mumol/g creatinine (0.52 +/- 0.16 mumol/mmol creatinine) and 15 +/- 8.0 nmol/L GF in patients using an extra gram of Ca carbonate daily and 6.5 +/- 2.6 mumol/g creatinine and 32 +/- 18 nmol/L GF in patients consuming dietary Ca (p less than 0.05). Serum Ca was increased (p less than 0.05) in the supplemented group (9.8 +/- 0.4 vs 9.3 +/- 0.6 mg/dL [2.4 +/- 0.099 vs 2.32 +/- 0.14 mmol/L]) but urinary Ca and serum alkaline phosphatase were similar. Bone mineral density was the same in both (0.88 +/- 0.19 vs 0.87 +/- 0.08 g/cm2). We concluded that CAMP is greater in patients with no supplemental Ca in the diet. This test may be useful to assess patient compliance and biological availability of dietary or supplemental Ca.

Aged↗
PubMed1978

A computerized perinatal data system for a region.

The development of regionalized systems for perinatal care requires a record system which will provide a flow of patient information to and from referring and center hospitals. It should also provide for the risk evaluation of patients being cared for within the region as well as for the quality and statistical evaluation. When the Arizona Perinatal Program was established in 1975 with funding by the Robert Wood Johnson Foundation, the decision was made to adopt and expand a perinatal data system under development at St. Joseph's Hospital in Phoenix. This data system is made up of two major components: (1) a paper record system in which the documents completed by physician or nurse serve both as the medical record and a computer-input document and (2) a computer capable of simultaneous communication with 17 different terminals, directly or by telephone lines. Programs to meet the goals of patient care, quality evaluation, and statistical assessment are described.

Arizona↗
PubMed1973

Reactions to tetanus toxoid.

In a factory population the occurrence of reactions to tetanus toxoid was recorded after 6740 injections. The incidence of general reactions was 0.3% and of local reactions 2.6%. The local reaction rate to the first injection of the basic immunization course was 0.9%, to the second injection 2.7%, and to the third injection 7.4%. To booster injections the rate was 1.6%. The local reaction rate was appreciably higher in women than in men - 14.4% and 5.7% respectively in the case of the third injection - and the incidence among women increased with age.Tetanus vaccine containing 10 Lf of toxoid caused fewer reactions than one containing 20 Lf, but a reduction in the content of aluminium adjuvant did not affect the reaction rate.Almost all reactors were found to have a satisfactory serum antitoxin concentration at the time of the reaction or developed a satisfactory immunity within 1-6 months.Skin tests were made in 32 hypersensitive patients. Neither the diluent, thiomersal preservative, nor the culture medium appeared to be responsible for hypersensitivity. The degree of hypersensitivity elicited by a special highly purified toxoid was only very slightly less than that elicited by the commercially pure toxoid. It is suggested that reactions are largely due to the toxoid antigen itself rather than to impurities or other components of the vaccine.

Adjuvants, Immunologic↗