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Biomedical subjects

D G Wilson

Publications and source records attributed to D G Wilson.

At least 37 records · Page 2Linked to original sources
PubMed1991

The antinociceptive effects of anterior pretectal stimulation in tests using thermal, mechanical and chemical noxious stimuli.

Four behavioural tests have been used to study the antinociceptive effects of electrical stimulation of the anterior pretectal nucleus (APtN) in the rat. The antinociceptive effects of stimulating this nucleus, which lies dorsally in the posterior diencephalon, have recently been studied extensively but always using briefly applied heat stimuli. It is reported here that APtN stimulation effectively inhibited responses to briefly applied noxious pressure and longer-lasting noxious chemical (formalin) stimuli. Although the tail-flick reflex to noxious heat was very potently depressed by APtN stimulation, responses to noxious heat in the hot-plate test were not. Three doses of morphine were also studied with each test and it was concluded that 15 sec of 35 microA r.m.s. current into the APtN was as effective as 3-5 mg/kg morphine s.c. in the rat.

Animals↗
PubMed1990

Applications of skin grafting in large animals.

Injuries involving full-thickness skin wounds are common in large animals. Skin grafting can shorten the healing time and improve the cosmetic result. Techniques that have been used successfully in the management of full-thickness skin wounds include full-thickness skin grafts, split-thickness skin grafts, tunnel grafts, pinch/punch grafts, and immediate split-thickness skin grafts. The technical aspects of each of these procedures are detailed and representative cases are presented.

Animals↗
PubMed1989

Treatment of canker in horses.

Seven horses with canker had radical surgical debridement and various irritant substances applied to the wounds. Four of the horses were clinically normal in (mean) 3.6 months, 1 mare was lame, and 2 horses were euthanatized because of complications of their treatments. Seven horses that had minor surgical debridement and antimicrobial agents used systemically and topically were clinically normal in (mean) 1.4 months. Seemingly, canker in horses should be managed using minor surgical debridement and appropriate antimicrobial therapy.

Animals↗
PubMed1989

Synovial hernia as a possible complication of arthroscopic surgery in a horse.

A 3-year-old Standardbred gelding was referred for evaluation of a fluctuant swelling that developed over the dorsum of the carpus subsequent to arthroscopic surgery on that carpus. A synovial hernia was diagnosed and surgically repaired. Although complications secondary to arthroscopy are rare, synovial herniation can develop after arthroscopic surgery. The condition must be differentiated from the more common true bursitis or false bursitis that is commonly referred to as a hygroma.

Animals↗
PubMed1989

Surgical management of urovagina and associated infertility in a cow.

Severe urovagina, secondary to a calving injury, was diagnosed as the cause of necrotizing endometritis and infertility in a Holstein cow. Urethral extension surgery resulted in resolution of the urovagina and endometrial recovery. Temporary paresis of the bladder was a postsurgical complication. The cow conceived promptly after insemination, but suffered similar injuries subsequently during calving.

Animals↗
PubMed1989

A search for lymphatic drainage of the monkey orbit.

Colloid solutions of technetium Tc 99m and india ink injected into the retrobulbar space of the cynomolgus monkey outside the extraocular muscle cone were removed from the orbit by the lymphatic vessels of the conjunctiva and eyelids and were then concentrated within the lymph nodes that drained the conjunctival and eyelid areas. Colloid solutions injected into the retrobulbar space inside the extraocular muscle cone did not reach the conjunctiva and did not collect in any lymph nodes over a 24-hour period. Within the orbit, the injected colloids spread along the planes of the connective-tissue septa. No lymphatic vessels were identified within the orbits posterior to the conjunctiva. Small amounts of india ink left the posterior orbit and ultimately entered the contralateral orbit. This posterior pathway did not lead to lymphatic vessels or lymph nodes and therefore does not appear to represent a prelymphatic pathway.

Animals↗
PubMed1988

Antagonism of N-methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK-801.

1. Extracellular single neurone recordings were made in the ventrobasal thalamus of urethane-anaesthetized rats. 2. Iontophoretically and intravenously administered ketamine and MK-801 were found to be selective antagonists of responses of neurones to iontophoretically applied N-methylaspartate. 3. Both antagonists, administered in N-methylaspartate-selective quantities, reduced the synaptic responses of ventrobasal thalamus neurones to a two-second air jet directed at the peripheral receptive field.

Animals↗
PubMed1985

Clinical response of a patient with diffuse histiocytic lymphoma to adoptive chemoimmunotherapy using cyclophosphamide and alloactivated haploidentical lymphocytes. A case report and phase I trial.

Adoptive chemoimmunotherapy has cured experimentally induced tumors in animals, but its clinical use has been limited. Six patients were treated with refractory neoplasms in a Phase I study with cyclophosphamide (CPM) and alloactivated haploidentical lymphocytes. Patients received an immunosuppressive dose of CPM (800 mg/m2) followed by haploidentical lymphocytes primed in vitro with alloantigens in mixed lymphocyte culture (MLC). One week later patients received a second infusion of alloactivated lymphocytes expanded in T-cell growth factor (TCGF). The total number of cells given to each patient progressively increased, with a single patient receiving 35.5 X 10(9) cells. Transient febrile responses and delayed-type hypersensitivity reactions at the intravenous sites were the only toxicities noted. A complete clinical response lasting 12 weeks was seen in a single patient with diffuse histiocytic lymphoma. Our experience indicates that adoptive chemoimmunotherapy can be given to patients safely and merits further clinical testing.

Blood Transfusion↗
PubMed1984

The inventory of socially supportive behaviors: dimensionality, prediction, and gender differences.

The nature of social support as measured by the Inventory of Socially Supportive Behaviors (ISSB) was explored in the study. The results of a principal components analysis suggest that it is appropriate to use the ISSB as a global measure of a unidimensional construct. The components that emerged were interpretable, however, and are consistent with the types of social support that have been cited in the literature. Males and females do not differ in overall social support as measured by the ISSB, but females report receiving more emotional support than males do. Social network variables predicted ISSB scores for males but not for females. The network variable that predicted social support most strongly was the number of people a respondent felt close to and could confide in or turn to for help in an emergency. The meanings and implications of these findings are discussed.

Adaptation, Psychological↗
PubMed1984

Scintigraphic assessment of perivesical urinary extravasation following renal transplantation.

Radionuclide scintigraphy is a safe and accurate means of detecting postoperative urologic complications in renal transplant recipients. Early identification of urinary leakage coupled with aggressive intervention significantly reduces the associated morbidity and mortality. Perivesical extravasate may be difficult to distinguish from adjacent or nearby bladder activity on scintiscan. Clarification of actual bladder contour and determination of its exact location within the pelvis may resolve such uncertainties. We describe imaging techniques that define the anatomic extent of the bladder and demonstrate our scintigraphic assessment of perivesical extravasation.

Adult↗
PubMed1984

Unsuspected extra-abdominal sites of infection: scintigraphic detection with indium-111-labeled leukocytes.

Scintigraphy with indium-111-labeled leukocytes (In-111-WBC) was assessed in 128 patients with suspected abdominal-pelvic abscesses. Studies were positive in 37 of 41 patients with proved abscesses, in two of two with infected aortic grafts, and in 12 of 15 with other infections; studies were negative in 63 of 70 cases without infection. The sensitivity of leukocyte scintigraphy in this series was 88%, specificity 90%, and accuracy 89%. Sixteen percent of all patients studied with In-111-WBC scintigraphy had unexpected sites of infection outside the abdomen. Of the 58 patients with proved infection, 20 (34%) had alterations in diagnostic evaluations and therapeutic regimens due to such findings.

Abdomen↗