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Biomedical subjects

D G Johnson

Publications and source records attributed to D G Johnson.

297 records · Page 17Linked to original sources
PubMedDate not supplied

Effects of single large doses of phenytoin on glucose homeostasis--a preliminary report.

The effects of a loading dose of 15 mg/kg phenytoin by iv infusion on the serum levels of insulin, glucagon, and glucose were investigated in five fasting healthy male volunteers between the ages of 23 and 35 years. Serum glucose concentrations rose immediately after the infusion of phenytoin followed by a significant increase in serum insulin values (P less than 0.05). A slight elevation in mean glucagon concentrations after the infusion was not statistically significant. Further studies are indicated to determine whether phenytoin as used in the treatment of status epilepticus may aggravate the hyperglycemia associated with seizures.

Adult↗
PubMedDate not supplied

Crisis management: forewarned is forearmed.

Big disasters remind executives that crisis communications is a critical part of strategic planning. But consciousness fades quickly, and with it, response time. Don't be caught unprepared.

Communication↗
PubMedDate not supplied

Removal of corneal epithelium with phototherapeutic technique during multizone, multipass photorefractive keratectomy.

BACKGROUND: The therapeutic mode of the VISX 20/20 excimer laser was used to remove the corneal epithelium prior to performing photorefractive keratectomy (PRK) with a multizone, multipass technique. METHODS: A retrospective analysis was performed of 120 eyes of 90 patients that were treated for preoperative spherical refractive errors from -1.00 to -7.00 diopters (D) (mean -3.90 D, SD 1.54) by one surgeon (DGJ) over 7 months. RESULTS: Six-month follow-up was obtained in 76 eyes (63%). Sixty-nine eyes (91%) achieved a spherical equivalent refraction within +/-1.00 D of emmetropia. Regression of effect averaged -0.35 D (SD 0.53 D) from 1 to 6 months after surgery. Mean postoperative uncorrected visual acuity at 6 months was 20/25 (range 20/15 to 20/200). Seventy-three eyes (96%) achieved uncorrected visual acuity of 20/40 or better, 67 (88%) achieved uncorrected visual acuity of 20/25 or better, and 76 (71%) achieved 20/20 or better. Three eyes (4%) lost one line of spectacle-corrected visual acuity; no eye lost more than one line. There were no significant surgical complications. CONCLUSION: Removal of corneal epithelium with the Summit Excimed UV 200 LA excimer laser using multizone, multipass photoablation yields visual and refractive results that compare favorably with published PRK series with excellent short-term stability.

Adolescent↗
PubMedDate not supplied

Female graduates of a predominantly black college of medicine: their characteristics and challenges.

To obtain detailed information about the general characteristics of and the special challenges faced by its predominantly black female graduates. Howard University College of Medicine included an oversampling of women in an extensive 1985-1986 follow-up survey of alumni. Women were asked specific questions about their experiences as women medical students and physicians. Comparative results for the 168 female and 560 male respondents show interesting similarities and differences. Male and female respondents serve the same large proportion of black and female patients, while a higher proportion of the women practice in large cities, provide primary care, and serve younger and poorer patients. Special challenges of being women in medicine include lack of support from faculty, spouses, and colleagues, especially in the areas of child rearing and household management. Although comparisons of earlier (1924-1969) and later (1970-1980) women graduates reveal some improvements, findings include a continuing need to eliminate the dual problems of sexism and racism that have historically faced black women medical students and physicians. Suggestions for continued improvement include support groups, consciousness raising activities, and further research related to women in medicine.

Adult↗
PubMedDate not supplied

Congenital chest wall mesenchymal hamartoma.

The case of an infant with mesenchymal hamartoma of the chest wall is presented, and the role of conservative diagnostic and therapeutic intervention is emphasized. A large mass that involved the right hemithorax and chest wall was detected in utero on routine ultrasonographic studies and diagnosed as mesenchymal hamartoma by percutaneous fine needle biopsy at 4 days after birth. The mass did not enlarge after birth, but surgical debulking was necessary at 1 month because of progressive respiratory compromise. Tumor regrowth was noted over the ensuing 8 months, and a second debulking at 9 months has been followed by a 6-year interval without evidence of recurrence.

Hamartoma↗