Biomedical subjects
D G James
Publications and source records attributed to D G James.
The prospects for fish for the malnourished.
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Hepatic granulomas.
There are several causes of hepatic granulomas, infective and non-infective. Modern technology, including monoclonal antibody techniques and histochemistry, has shed light on the morphology of the sarcoid granuloma. There are numerous causes of hepatic granulomas, both infective and non-infective. The causes are listed and a clinico-pathological plan of management outlined.
Antibiotics: a clinical update.
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In honour of the past, present and future.
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Lupus pernio: a clinico-radiological study of thirty-five cases.
Thirty-five patients with lupus pernio were observed in a series of 818 patients with clinical and histological evidence of sarcoidosis. This analysis provides the natural history of lupus pernio and its associated clinico-radiographic features. There was intrathoracic involvement in 74% of patients, upper respiratory tract disease in 54%, reticulo-endothelial involvement in 54%, bone cysts in 43% and ocular lesions in 37%. It predominated in West Indies-born women. Histological confirmation was easily obtained by nasal mucosal biopsy and this could be repeated serially to evaluate the response to various treatments. Nasal bone radiographs showed destruction of the nasal bones, porosis and alteration in bone texture. Peripheral bone cysts were evident in 50% of patients who were radiographed, and in about 50% of these patients, the cysts were found in both hands and feet.
Overlap syndromes with sarcoidosis.
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Postgraduate medicine and personalities--1925.
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Alimentary tract granulomas.
Sarcoidosis rarely affects the alimentary tract and is usually asymptomatic. However, sarcoid granulomas are commonly found as a reaction to a local cause or as a feature of other systemic disease. Thus, the differential diagnosis of alimentary tract granulomas is wide. Before accepting a diagnosis of sarcoidosis of the alimentary tract, it is important to exclude its many mimics.
The Baltimore Conference.(Tenth International Conference on Sarcoidosis).
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Immunodeficiency.
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Overlap syndromes with sarcoidosis.
It is hoped that readers of this article will make a note of any other disorders which occur in their patients with sarcoidosis. We shall welcome this list and the frequency with which other disorders coincide with sarcoidosis.
A tale of two cities.
This is a comparison of two large series of histologically-confirmed sarcoidosis-797 patients kept under supervision in Hamburg and 818 patients in London. There are a few differences but many striking similarities. The factual data in these two series should provide guidelines for present and future investigators recognising sarcoidosis as it emerges from obscurity in Africa, India and Asia.
Sarcoidosis is not associated with the HTLV III virus.
Superficial immunological similarities between sarcoidosis and AIDS led to this radioimmunoassay survey of serum antibodies to HTLV III virus in 17 patients with active sarcoidosis, 8 with peripheral lymphadenopathy. Serum antibodies were negative in all patients with sarcoidosis.
Cyclosporin A in the treatment of posterior uveitis.
Cyclosporin A was used in nine patients with severe refractory posterior uveitis. Four patients had Behcet's disease, one had sarcoidosis, one had HLA B27 related arthritis and uveitis and three had idiopathic retinal vasculitis. The drug had beneficial ocular effects in all patients in the early stages of treatment with an improvement in the visual acuity and reduction in the severity of inflammation. The relapse rate and need for additional steroids were reduced in all patients. However, renal function deteriorated in seven patients to such an extent that the dose of Cyclosporin A had to be reduced with consequent relapse of uveitis.
The patient with poor resistance.
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The changing pattern of tuberculosis.
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