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Biomedical subjects

D G Goodman

Publications and source records attributed to D G Goodman.

24 records · Page 2Linked to original sources
PubMedDate not supplied

Suppression of autoimmunity in NZB mice with steroid-sensitive X-radiation-sensitive syngeneic young thymocytes.

NZB mice spontaneously lose thymic regulatory or suppressor cells and subsequently develop autoimmunity and lymphoreticular hyperplasia. Treatment with 2-week-old syngeneic thymocytes every 2 weeks starting at 4 weeks of age suppressed these disease manifestations. The active thymocyte subpopulation was found to be sensitive to corticosteroids and X-irradiation.

Animals↗
PubMedDate not supplied

Quality assurance for pathology in rodent carcinogenesis tests.

A large scale national carcinogenesis testing program requires quality assurance procedures for each scientific discipline, including pathology. The NCl Carcinogenesis Testing Program's pathology procedures involve the necropsy examination, histology, histopathologic diagnosis, data recording, and report writing. Each phase of the program requires specific quality assurance procedures, some of which are clerical, others scientific. In the latter case, a consensus from a group of pathologists serves to resolve differences of opinion. Only with the implementation of quality assurance procedures will the confidence in these tests be assured and quality maintained. Subsequently, modifications to established protocols may be discussed and accurately evaluated.

Animals↗