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D G George

Publications and source records attributed to D G George.

At least 37 records · Page 2Linked to original sources
PubMed1988

The protein identification resource (PIR).

The Protein Identification Resource consists of an integrated computer system composed of a number of protein and nucleic acid sequence databases and software designed for the identification and analysis of protein sequences and their corresponding coding sequences. The PIR serves the scientific community through on-line access, distributing magnetic tapes, and performing off-line sequence identification services for researchers.

Amino Acid Sequence↗
PubMed1988

Identifying domains in protein sequences.

Amino acid sequences are often inferred without information about the structure or function of the protein. Just as unknown proteins may be identified through comparison with other known sequences, so can structural and functional domains be inferred through analogy with other known domain sequences. A database of domain sequences, along with their known properties, would be very helpful in the characterization of a protein sequence in terms of its possible conformation and function. Here we describe the type of information to be included in such a database and discuss the techniques that may be used to determine the characteristic features of domains. Recently identified domains in thyroid peroxidase, chondroitin-sulfate proteoglycan core proteins, an epidermal growth factor precursor homolog, and a bacterial beta-amylase are presented as examples.

Amino Acid Sequence↗
PubMed1987

A standardized format for sequence data exchange.

At present there is no agreement upon a standard format for the presentation of sequence data; each of the major sequence databases has adopted their own format. As a result, efforts to pool these data and to develop software to manipulate the data have been hampered. A significant amount of software development time must be invested to handle the incompatibilities among these formats before software to solve biologically interesting problems can be implemented. In principle, the development of a standard format by the database distributors would be the best solution. However, because the databases have invested years of effort in the development of procedures specifically tailored to their own format, they are reluctant to change. Insisting that they convert to a new format would place an extreme burden on the already overtaxed resources of these groups. Furthermore, for certain specialized applications it is more efficient to present the data in nonstandard formats. An alternative solution is presented here. Rather than develop a single standard format for all sequence data, a standardized exchange format has been developed. This format was designed to serve as a common interface between the major formats currently in use. Data can be easily converted to and from it without significant loss of information. This alleviates difficulties inherent in dealing with multiple formats while preserving the local formats of the various databases.

Amino Acid Sequence↗
PubMed1986

The protein identification resource (PIR).

The Protein Identification Resource, which provides the scientific community with an efficient on-line computer system designed for the identification and analysis of protein sequences and their corresponding coding sequences, has been established. The resource consists of an integrated computer system composed of a number of protein and nucleic acid sequence databases and the software necessary to analyze this information effectively.

Amino Acid Sequence↗