Biomedical subjects

D G Brownstein

Publications and source records attributed to D G Brownstein.

57 records · Page 4Linked to original sources

PubMed1975

Nasal carcinoma in a captive Eld's deer.

A 7-year-old Eld's deer (Cervus eldii) developed a swelling rostromedial to the left eye in association with signs of weakness, blindness, and discomfort. By means of radiography and biopsy, the swelling was found to be a carcinoma of lining epithelium of the caudal nasal cavity and left frontal sinus. Within 2 weeks of initial observation, signs of neurologic involvement developed and the deer was euthanatized. Necropsy revealed metastasis to lungs, liver, kidneys, and abdominal lymph nodes.

Animals↗

PubMedDate not supplied

Sendai viral pneumonia in aged BALB/c mice.

Sendai virus (SV) infection in aged BALB/c mice was evaluated as a natural model for age-associated susceptibility to viral pneumonia. Young (2 month-old) and aged (22-24 month-old) BALB/c mice were inoculated intranasally with 100 median pneumonia doses (PD50) of SV and examined at 6, 10, and 20 days by virus titration, immunohistochemistry, histopathology, and serology. The aged mice had significantly higher virus titers in lung, prolonged infection, delayed development, and resolution of pneumonia and significantly lower serum antibody titers. In a second experiment, the responses of young mice were compared to intermediate-aged mice (11-13 and 17-18 months old). The intermediate-aged mice had some characteristics of young mice and others of aged mice. The results indicate that SV infection can be used to study aging-associated susceptibility to a pneumotropic virus in a natural host, and that susceptibility of mice to viral pneumonia increases gradually during aging.

Adenoma↗

PubMedDate not supplied

Infection in rabbits with the Lyme disease spirochete.

Of 33 rabbits inoculated with Lyme disease spirochetes, two developed erythema chronicum migrans at the site of inoculation. Spirochetes were seen in skin biopsies of one of the lesions with immunoperoxidase and Warthin-Starry stains. Spirochetes were also recovered from the blood of two additional rabbits two weeks post-inoculation. These findings are characteristic of early Lyme disease in humans.

Animals↗