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Biomedical subjects

D G Baker

Publications and source records attributed to D G Baker.

At least 163 records · Page 9Linked to original sources
PubMed1975

Cardiac output and its distribution during diving in the rat.

The diving response was produced by submerging the head of the unanesthetized rat for 60 s, while it was confined in a mesh-wired cone. Heart rate and cardiac output decreased by 73% and 74% from the predive values, respectively, indicating insignificant change in stroke volume. Central systemic arterial blood pressure rose by 22% during diving and a fourfold increase in total peripheral resistance was observed. Blood flow to the coronary, cerebral, and bronchial circulations remained unchanged while a 95% reduction in the intestine and the spleen, a 97% reduction in the kidney, and greater than 99% reduction in the tail and skin were observed during diving. The blood flow reduction from predive values ranged from 50% for liver and skeletal muscle to 75% for the adrenals and 65% for the diaphragm. The redistribution of the drastically reduced cardiac output during head immersion in the rat is similar to that reported for diving mammals. It is suggested that the rat may serve as a useful cardiovascular model for further studies of the diving response in mammals.

Adrenal Glands↗
PubMed1975

Protection of the skin of mice against irradiation with cyclotron-accelerated helium ions by 2-mercaptoethylamine.

Mouse skin was exposed to doses of 1 250 to 3 000 rad using a helium ion beam with modal LET of 15 keV per micron. The skin reactions were evaluated for mice treated with a topical application of 10% MEA in a cream base or a placebo 15 minutes before irradiation. A comparison of the skin reactions indicated that the MEA treatment resulted in a DMF of at least 1.2. The implication for radiation therapy was discussed.

Administration, Topical↗
PubMed1975

Radiobiology and the role of the radiobiologist in the context of a teaching-oriented radiation oncology department.

This discussion concerns the function of a radiobiologist in the radiation oncology department of a hospital which maintains a radiation oncology training program. This involves teaching and research, both of which contribute to the oncology residents' total learning experience. The teaching commitment emphasizes the radiobiological basis of clinical problems, and makes use of both lectures and clinical experience to generate the teaching situations. As a part of the research commitment, the radiobiologist acts as an interface between clinical experience and research. He accomplishes this by maintaining a research program oriented toward clinical problems and organizing a research rotation during which the oncology trainees are able to participate in a specific research project. Radiobiology teaching and research must be relevant to the clinical experience of the oncologist.

Education, Medical, Continuing↗
PubMed1975

Relationship between RBE and depth dose for 23-MeV electrons.

A study comparing the RBE in depth of 23-MeV electrons was performed. A mouse sarcoma (KHT) maintained by serial passage in the C3H/HeJ female mouse was irradiated. Under the 23-MeV electron beam at the 100-percent and 14-percent isodose positions and under the 60Co beam at the 100-percent isodose position. The data failed to demonstrate a difference in biological effectiveness for the 23-MeV electron beam comparing the 14-percent isodose to the 100-percent isodose position.

Animals↗