Biomedical subjects
Publications and source records attributed to D Fried.
Three patients with Schönlein-Henoch syndrome developed severe muscle pain in the legs. The pain, so severe that they were bedridden, subsided within a few days and was caused, we believe, by bleeding into the leg muscles.
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We analysed the peripheral leukocyte count of 80 children with shigella gastroenteritis. The total leukocyte count varied widely from leukopenia to leukocytosis, and is therefore of little value in differentiating shigellosis from viral gastroenteritis. The leukocyte differential count, however, revealed a striking shift to the left in 71% of the patients. This parameter may help in the preliminary diagnosis of shigella gastroenteritis. We have stressed the fact that three pediatric textbooks do not refer to this aspect in their relevant chapters on shigellosis.
A female neonate with severe varicella is reported. She was treated with THF and a leukocyte transfusion from her convalescent mother. This procedure seems to have been a turning point, after which she recovered fully. There were no untoward effects from this treatment.
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We describe a boy with an unusual adverse reaction to dyphenylhydantoin (DH). This 12 years old boy developed a clinical picture of high fever, scarlatiniform rash, a hemorrhagic (purpuric) skin lesion, on his buttocks and neck, stomatitis and conjunctivitis, within two weeks after DH administration. Laboratory examinations were compatible with the diagnosis of disseminated intravascular coagulation. Cases similar to ours are reviewed and it is stressed that DH should be used cautiously as it is not a harmless drug.
Steady state intravenous tyramine dose pressor-response tests were administered to a patient with bipolar illness during depressed and hypomanic phases of her illness. The greatest tyramine sensitivity while unmedicated occurred when the patient was hypomanic, and the least sensitivity when she was depressed before her first switch. The data raise the possibility that changes in peripheral alpha-adrenergic receptor sensitivity accompany spontaneous mood cycles. Tyramine produced a replicable mood and cognitive alteration only in the infusion closest to the switch from hypomania to depression, suggesting that the CNS may be particularly susceptible to peripheral noradrenergic inputs at specific points in bipolar illness.
In this report, we describe torsion of the spleen in a five-and-a-half-month-old infant, thus far the youngest reported patient in the literature. Celiac angiography and tuftsin determination confirmed the clinical impression that the pathology was confined to the spleen. The infant underwent a splenectomy and made an uneventful recovery.
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A 17 month-old child with laryngeal papillomata is presented. The symptoms were stridor and gradually developing dyspnea. He underwent two surgical procedures within 4 months, using microsurgical techniques, and eventually recovered. The etiological factors of this rare entity are discussed. The relatively benign course in our patient is stressed, in view of the usual protracted course which is reflected in the literature.
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A case of a female newborn with agenesis of the right hemidiaphragm is presented. The defect was corrected with a double sheet of Marlex, attached to a rim of endothoracic fascia and muscle. At the age of 5 yr, the child is in perfect health.
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