Using learning theory to design and evaluate computer-assisted instruction software.
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Computer-Assisted Instruction↗
Biomedical subjects
D French
Publications and source records attributed to D French.
Development of child-centered disease-specific questionnaires for living with asthma.
Contemporary developments in the management of chronic diseases such as diabetes and asthma offer possibilities for optimal control, but patients increasingly need to take on responsibilities for self care. Health professionals require comprehensive assessments of outcome that include data reflecting patients' perceptions of their disorder and its management. Disease-specific, patient-centered questionnaires for evaluation of adults' health-related quality of life are available for diabetes and asthma. Little progress is evident in relation to pediatric instruments. This paper describes the development of such an instrument for measurement of 8- to 11-year-olds' perceptions of their asthma--the CAQ-B Psychometric characteristics of the CAQ-B are reported: principal axis factor analysis resulted in the derivation of four subscales reflecting children's perceptions of both active and passive aspects of living with asthma, together with their perceptions of its severity and any associated distress. Preliminary explorations with CAQ-B included comparisons of parents', doctors', and children's ratings of severity; comparisons of data from asthmatic and nonasthmatic children; comparisons of data from boys and girls.
Adaptation, Psychological↗
Survey of driver rehabilitation programs.
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Automobile Driver Examination↗
HPV infection and microsatellite instability in squamous lesions of the uterine cervix.
The role of human papillomavirus (HPV) in the development of squamous lesions of the uterine cervix has been clearly established but other factors could be involved in cervical tumorigenesis, such as microsatellite instability (MI). The aim of the present study was to analyze the relationship between HPV infection and MI. Thirty-two cervical samples were analyzed: 11 low-grade CIN (LCIN), 18 high-grade CIN (HCIN) and 3 carcinomas. DNA was extracted from formalin-fixed, paraffin embedded tissue for PCR study with HPV 6/11, 16, 18 and 7 microsatellite primers: D2S123 (cr2), MFD39 (cr8), 635-636 (cr15q), MFD67 (cr1), D11S905 (cr11), SCZD1 (cr5q) and DM (cr19). HPV was detected in 82% of LCIN (16 and 18 types in 64% of cases) and in 33% of HCIN (16 type in 22% of cases). The difference between LCIN and HCIN was statistically significant (p = 0.014), in particular for 16 and 18 HPV types (p = 0.033). Forty-seven per cent of total cases showed MI with no more than 3 different loci per case: 27% of LSIL, 61% of HCIN and 33% of carcinomas (not statistically significant). In 45% of HCIN cases there were both MI and HPV. In conclusion, cervical carcinoma is linked to HPV infection but MI could also be involved in cervical tumorigenesis.
Adult↗
Civilian and military ambulance workers face different challenges.
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Allied Health Personnel↗
Microsatellite alterations in uterine leiomyomas.
Recent studies have shown that microsatellites instability (MI) has a leading role in the development of different types of cancer: a high rate of di-tri or tetranucleotide repeats have been found in familial polyposis and in sporadic colorectal, gastric, breast and endometrial carcinomas. In the present study, we selected the DNA of 23 histological samples from patients with uterine leimyomas, aged between 24 and 65 years. The negative portion was divided from the pathological portion in the same sample of each patient. Each sample was analyzed for 7 microsatellites (D25123, Mfd39, 635. 636. Mfd67, D11S905, SCZD1 and DM) through double amplification with the PCR using external and internal primer couples. Seven of 23 samples analyzed on the denaturant gel of acrylamide (30.4%) were positive for microsatellite alterations. The recurrence of these alterations, which appear in our study, suggest their involvement in benign transformation of smooth muscle cells.
Adult↗