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Biomedical subjects

D Fox

Publications and source records attributed to D Fox.

At least 55 records · Page 3Linked to original sources
PubMed1993

The modulation of ocular growth in rabbits with peripheral retinal ablation.

PURPOSE: To study the effects of transcleral cryotherapy and laser photocoagulation of anterior retina on ocular growth. METHODS: Twenty-one rabbits underwent transcleral cryotherapy or indirect ophthalmoscopic laser photocoagulation of the anterior retina on one of their eyes between 2 and 8 weeks of age. RESULTS: After the rabbits were killed between 3 and 6 months of age, treated rabbit eyes were found to be significantly smaller in axial length (P < 0.001), average equatorial diameter (P < 0.01), average corneal diameter (P < 0.05), and in total ocular volume (P < 0.01). The difference in eye size was not due to lowered intraocular pressure. CONCLUSIONS: The results demonstrate that these treatments slow growth of both the anterior and posterior segment of rabbit eyes.

Animals↗
PubMed1993

T-lymphocyte clones initiated from lesional psoriatic skin release growth factors that induce keratinocyte proliferation.

To investigate whether growth factors derived from T cells in psoriatic lesions are able to stimulate keratinocyte growth, T-cell lines were initiated from lesional psoriasis skin and cloned by limiting dilution. Eight clones with good proliferative capacity out of 40 clones from one patient were stimulated. After 24 h, the conditioned medium was harvested and the growth modulatory effect of the conditioned medium on keratinocytes was assessed. Seven of the eight T-cell clones stimulated keratinocyte growth to an extent ranging from 22% +/- 19 to 64% +/- 9 (mean +/- SD of three experiments) of maximal inducible keratinocyte growth, and one T-cell clone had no effect (-5% +/- 2) on keratinocyte growth. Keratinocyte growth was also induced by T-cell clones obtained from two other patients. Several cytokines were tested in this system to determine which T-cell growth factor may induce the keratinocyte growth. None of the cytokines interferon-g, transforming growth factor-beta, interleukin (IL)-2, IL-3, IL-4, IL-6, IL-8, or granulocyte-macrophage colony stimulating factor alone was found to possibly be responsible for the T-cell-induced keratinocyte growth. Thus the nature of the T-cell keratinocyte growth-promoting stimulus remains to be elucidated.

Cell Division↗
PubMed1993

The challenge of predicting response to stabilising lithium treatment. The importance of patient selection.

Lithium treatment, an approach with well documented efficacy, has recently been losing its treatment value. Lithium continues working, however, for those patients for whom it was proven efficacious; that is, most patients with primary episodic affective disorders. Such responders to lithium prophylaxis can be reliably identified beforehand by a comprehensive clinical assessment. The explanation for the paradox of lithium's lost efficacy lies mostly in the educational bias against a comprehensive patient assessment, and in the shift in diagnostic fashion favouring affective disorders and the treatment methods associated with them in the clinicians' minds.

Depressive Disorder↗