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Biomedical subjects

D Flynn

Publications and source records attributed to D Flynn.

44 records · Page 3Linked to original sources
PubMed1976

Aggression in captive pigtail monkey groups: effects of provision of cover.

To assess the influence of provision of "cover" on aggressive behavior in captive nonhuman primate groups, concrete cylinders were introduced into rooms in which six groups of pigtail monkeys resided. Basal incidence of aggression was measured prior to introduction of the cylinders and during their presence in the rooms. Four groups, which underwent little or no change in group composition during the study, exhibited substantially less aggression when cover was available than when it was not. Moderate and extreme changes in group composition occurred in two groups; these changes resulted in slight and dramatic increases in aggression, respectively, at the times when the changes occurred. Subjects frequently used the cylinders to avoid the concrete cylinders resulted in decreased aggression in stable groups but did not prevent aggression in groups which underwent moderate or extreme social change.

Aggression↗
PubMedDate not supplied

Serotonin 5-HT3 antagonists fail to affect ethanol self-administration of rats.

Five Long-Evans hooded rats were trained to lever press according to fixed-ratio 5 reinforcement schedules for 0.06 ml dipper deliveries of 8% w/v ethanol during daily (M-F) 0.5-h experimental sessions. After ethanol self-administration was established, doses of the serotonin 5-HT3 antagonists, ondansetron (0.03-3.0 mg/kg), granisetron (0.01-1.0 mg/kg), and SC-51296 (0.1-10.0 mg/kg) were administered prior to ethanol sessions to determine their effects on ethanol self-administration. None of the doses of the antagonists had significant effects on numbers of obtained ethanol deliveries. Subsequently, each antagonist (ondansetron, 0.1 mg/kg; granisetron, 0.3 mg/kg; SC-51296, 0.1 mg/kg) was administered b.i.d. for five consecutive daily sessions. During none of these chronic tests with the 5-HT3 antagonists were there significant main effects of drug administration. Overall, these results do not support the hypothesis that the serotonin 5-HT3 antagonists would have robust therapeutic efficacy in the treatment of alcoholism.

Alcoholism↗