Search PubMed⌕ Search

Biomedical subjects

D Fink

Publications and source records attributed to D Fink.

At least 127 records · Page 7Linked to original sources
PubMed1982

[Remote flap transplantation using microvascular anastomosis for scar correction (author's transl)].

The method of tissue displacement from a donor region to a receiving area with the help of microvascular anastomosis represents a synthesis of the traditional classical remote flap graft and free tissue transplantation. The method of defect replenishment with the help of a freely transplanted skin-fat-connective tissue flap from the groin region (groin flap) is demonstrated by the example of a correction of a shrinking scar on the neck of a 21-year-old patient, and the anatomical basis and operation technique are described. The advantages and disadvantages of the method are discussed.

Adult↗
PubMed1980

Avoidance of certain systematic pitfalls in the detection of HLA-DR antibodies defining find specificities.

A selective screening program has been established to identify rapidly and effectively the fine specificity of HLA-DR antibodies in pregnancy anti-HLA sera. Following initial HLA-A, B, C screening sera with extra- or multispecific reactions were selected and specifically tested after platelet absorption on isolated B- and T-lymphocyte populations of the serum donor's husband. Identification of the HLA-DR serum. Multispecific anti-DR sera were defined and rendered operationally monospecific by titration. Some critical steps in a reliable assessment of HLA-DR typing reagents could be worked out. Weak HLA-A, B antibodies, B-cell auto- and Lewis antibodies may cause positive reactivity preferentially or even selectively on B lymphocytes. Of particular importance was the hidden presence of HLA-C specific antibodies, since they cannot be absorbed out of stored platelets. In addition they are not readily detectable through screening on typed panel cells. Because of the frequently very high linkage disequilibrium between HLA-B and HLA-C alleles it is difficult to select appropriately dissecting panel cells. The two points demonstrated above gain even more weight when isolated T and B cell populations are used for HLA-DR typing, because HLA-C antibodies preferentially kill B cells. In this fashion contaminating HLA-C antibodies are not only difficult to detect but can mimic the presence of HLA-DR antibodies.

Antibodies↗
PubMed1977

Oncornavirus-induced sarcoma formation obscured by rapid development of lethal leukemia.

Injection i.v. of avian erythroblastosis virus (AEV) strain ES4 causes a high incidence of leukemia and the death of most of the inoculated chicks within 2 weeks. As found earlier, the virus is defective for replication and transforms bone marrow cultures in vitro, and surprisingly, also chick embryo fibroblasts. Inoculation of transformed AEV cells negative for virus production into newborn chicks induced the formation of sarcomas only, whereas cells superinfected with helper virus induced the formation of erythroblastosis in addition to sarcomas. The helper virus alone caused neither sarcomas nor erythroblastosis during the experimental period. These findings were explained by the hypothesis that AEV-induced erythroblastosis develops more rapidly than do AEV-induced sarcomas and that animals receiving i.v. injections die of the leukemia before sarcomas become detectable. The observation that animals receiving i.m. injections of AEV developed sarcomas at the site of injection strongly supports this concept. Most of the animals that received i.m. injections also developed an erythroblastosis that was delayed, however, in comparison to the animals receiving i.v. injections. Our data also suggest that the erythroblastosis induced by AEV does not suppress the formation of sarcomas in the same animal.

Alpharetrovirus↗
PubMed1975

[Subcutaneous rupture of the long extensor tendon to the thumb].

The "spontaneous" subcutaneous rupture of the tendon of the extensor pollicis longus is reported and the etiology and the pathologie are discussed. In our opinion is the transfer of the extensor indicis the only operation to do in this case and gives the best results.

Female↗